Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function

Nature Communications

Volumn 8, Issue , 2017, Pages

  Zhang, Chi ^a   Lai, Maria B ^a   Khandan, Lavan ^a   Lee, Lindsey A ^a   Chen, Zhe ^a   Junge, Harald J ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; ESCRT PROTEIN; FRIZZLED 4; FRIZZLED PROTEIN; NORRIN; PROTEIN; UNCLASSIFIED DRUG; AAA PROTEIN; EYE PROTEIN; FZD4 PROTEIN, HUMAN; FZD4 PROTEIN, MOUSE; NDP PROTEIN, HUMAN; NDPH PROTEIN, MOUSE; NERVE PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; VPS4A PROTEIN, HUMAN;

BIOLOGICAL DEVELOPMENT; BLOOD; BRAIN; CELLS AND CELL COMPONENTS; LIGAND; NERVOUS SYSTEM; NEUROLOGY; PHYSIOLOGICAL RESPONSE; PROTEIN; RODENT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOCYTOSIS; ENDOSOME; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; LYSOSOME; MOUSE; MULTIVESICULAR BODY; NONHUMAN; PROTEIN FUNCTION; RECEPTOR BINDING; REGULATORY MECHANISM; RETINA; SIGNAL TRANSDUCTION; UBIQUITINATION; VASCULAR BIOLOGY; VASCULAR ENDOTHELIAL CELL; VITREORETINOPATHY; ANIMAL; ENDOTHELIUM CELL; EYE DISEASE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; METABOLISM; MUTATION; PROTEIN TRANSPORT; RETINA BLOOD VESSEL; RETINA DISEASE; WNT SIGNALING;

MUS;

ANIMALS; ATPASES ASSOCIATED WITH DIVERSE CELLULAR ACTIVITIES; BLOOD-BRAIN BARRIER; ENDOCYTOSIS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENDOSOMES; ENDOTHELIAL CELLS; EYE DISEASES, HEREDITARY; EYE PROTEINS; FRIZZLED RECEPTORS; HEK293 CELLS; HELA CELLS; HUMANS; IN VITRO TECHNIQUES; LYSOSOMES; MICE; MULTIVESICULAR BODIES; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE TISSUE PROTEINS; PROTEIN TRANSPORT; RETINA; RETINAL DISEASES; RETINAL VESSELS; UBIQUITINATION; VACUOLAR PROTON-TRANSLOCATING ATPASES; WNT SIGNALING PATHWAY;

EID: 85021699543     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms16050     Document Type: Article

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