Lysosomal cholesterol hydrolysis couples efferocytosis to anti-inflammatory oxysterol production

Circulation Research

Volumn 122, Issue 10, 2018, Pages 1369-1384

  Viaud, Manon ^c   Ivanov, Stoyan ^c   Vujic, Nemanja ^b   Duta Mare, Madalina ^b   Aira, Lazaro Emilio ^c   Barouillet, Thibault ^a   Garcia, Elsa ^c   Orange, Francois ^c   Dugail, Isabelle ^d   Hainault, Isabelle ^d   Stehlik, Christian ^e   Marchetti, Sandrine ^c   Boyer, Laurent ^c   Guinamard, Rodolphe ^c   Foufelle, Fabienne ^d   Bochem, Andrea ^f   Hovingh, Kees G ^f   Thorp, Edward B ^e   Gautier, Emmanuel L ^d   Kratky, Dagmar ^b   Dasilva Jardine, Paul ^f,g   Yvan Charvet, Laurent ^c   more..

^a Acquire Innovation Ltd   (Ireland)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITÉ CÔTE D'AZUR   (France)

^d INSERM   (France)

^e NORTHWESTERN UNIVERSITY   (United States)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

^g Staten Biotechnology BV   (Netherlands)

Author keywords

Cholesterol; Inflammation; Macrophage; Mitochondria; Oxysterols

Indexed keywords

25 HYDROXYCHOLESTEROL; 26 HYDROXYCHOLESTEROL; ACID LIPASE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; LIVER X RECEPTOR; LYSOSOME ENZYME; OXYSTEROL; RAC1 PROTEIN; CHOLESTEROL; CHOLESTEROL ESTER; CHOLESTEROL ESTERASE; CRYOPYRIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LYSOSOMAL ACID LIPASE, MOUSE; NEUROPEPTIDE; NLRP3 PROTEIN, MOUSE; RAC1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIAPOPTOTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFEROCYTOSIS; EFFUSION; ENZYME ACTIVATION; ENZYME DEGRADATION; HYPERCHOLESTEROLEMIA; LIPID HYDROLYSIS; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPLENOMEGALY; SYNTHESIS; ANIMAL; APOPTOSIS; C57BL MOUSE; ERYTHROCYTE; HYDROLYSIS; INFLAMMATION; LYMPHOCYTE; METABOLISM; MITOCHONDRION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CHOLESTEROL; CHOLESTEROL ESTERS; ERYTHROCYTES; HYDROLYSIS; HYPERCHOLESTEROLEMIA; INFLAMMASOMES; INFLAMMATION; LIVER X RECEPTORS; LYMPHOCYTES; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEUROPEPTIDES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OXYSTEROLS; RAC1 GTP-BINDING PROTEIN; RECEPTORS, LDL; SPLENOMEGALY; STEROL ESTERASE;

EID: 85052439024     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.312333     Document Type: Article

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