Boosting heterologous protein production yield by adjusting global nitrogen and carbon metabolic regulatory networks in Bacillus subtilis

Metabolic Engineering

Volumn 49, Issue , 2018, Pages 143-152

  Cao, Haojie ^a   Villatoro Hernandez, Julio ^a   Weme, Ruud Detert Oude ^a   Frenzel, Elrike ^a   Kuipers, Oscar P ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Bacillus subtilis; CcpA; CodY; Global transcription machinery engineering (gTME); Heterologous proteins; High throughput screening

Indexed keywords

BACTERIOLOGY; CARBON; ELECTROPHORETIC MOBILITY; MACHINERY; METABOLISM; MUTAGENESIS; NITROGEN; NUCLEIC ACIDS; NUTRIENTS; PRODUCTIVITY; TRANSCRIPTION;

BACILLUS SUBTILIS; CCPA; CODY; HETEROLOGOUS PROTEINS; HIGH THROUGHPUT SCREENING; MACHINERY ENGINEERINGS;

PROTEINS;

BETA GALACTOSIDASE; CARBON; CATABOLITE CONTROL PROTEIN A; HETEROLOGOUS PROTEIN; NITROGEN; PROTEIN; RECOMBINANT DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION REGULATOR CODY; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL STRAIN; CARBON METABOLISM; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION SYSTEM; GENE REGULATORY NETWORK; IMMUNOBLOTTING; MUTAGENESIS; NITROGEN METABOLISM; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RNA SEQUENCE; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; BIOSYNTHESIS; GENE EXPRESSION; GENETICS; METABOLISM;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; CARBON; GENE EXPRESSION; NITROGEN; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS;

EID: 85051378350     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2018.08.001     Document Type: Article

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