PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism

Genes and Development

Volumn 32, Issue 15-16, 2018, Pages 1035-1044

  Nelson, Victoria L ^a,b   Nguyen, Hoang C B ^a,b   Garcìa Cañaveras, Juan C ^c   Briggs, Erika R ^a,b   Ho, Wesley Y ^a,b   Dispirito, Joanna R ^a,b   Marinis, Jill M ^a,b   Hill, David A ^a,d   Lazar, Mitchell A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Department of Medicine   (United States)

^c PRINCETON UNIVERSITY   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Alternative activation; Glutamine; Macrophage; Metabolism; PPAR ; Rosiglitazone

Indexed keywords

FATTY ACID; GLUCOSE; GLUTAMINE; INTERLEUKIN 4; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ROSIGLITAZONE;

ADULT; ALTERNATIVE ACTIVATION; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DENSITY; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; DOWN REGULATION; ENHANCER REGION; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION; GENE ONTOLOGY; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HIGH THROUGHPUT SEQUENCING; IMMUNOBLOTTING; LIPID METABOLISM; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RNA ISOLATION; RNA SEQUENCE; TIGHT JUNCTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL RESPIRATION; DRUG EFFECT; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL RESPIRATION; CELLS, CULTURED; FATTY ACIDS; GENE EXPRESSION; GLUCOSE; GLUTAMINE; INTERLEUKIN-4; MACROPHAGE ACTIVATION; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; PPAR GAMMA; THIAZOLIDINEDIONES;

EID: 85051264462     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.312355.118     Document Type: Article

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