Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature

Volumn 556, Issue 7699, 2018, Pages 113-117

  Mills, Evanna L ^a,b,c   Ryan, Dylan G ^a   Prag, Hiran A ^d   Dikovskaya, Dina ^e   Menon, Deepthi ^a   Zaslona, Zbigniew ^a   Jedrychowski, Mark P ^b   Costa, Ana S H ^f   Higgins, Maureen ^e   Hams, Emily ^g   Szpyt, John ^b   Runtsch, Marah C ^a   King, Martin S ^d   McGouran, Joanna F ^a   Fischer, Roman ^h   Kessler, Benedikt M ^h   McGettrick, Anne F ⁱ   Hughes, Mark M ^a   Carroll, Richard G ^a,c   Booty, Lee M ^c,d   Knatko, Elena V ^e   Meakin, Paul J ⁱ   Ashford, Michael L J ⁱ   Modis, Louise K ^c   Brunori, Gino ^c   Sévin, Daniel C ^j   Fallon, Padraic G ^g   Caldwell, Stuart T ^k   Kunji, Edmund R S ^d   Chouchani, Edward T ^b   Frezza, Christian ^f   Dinkova Kostova, Albena T ^e,l   Hartley, Richard C ^k   Murphy, Michael P ^d   O'Neill, Luke A ^a,c   more..

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g TRINITY COLLEGE DUBLIN   (Ireland)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ UNIVERSITY OF DUNDEE   (United Kingdom)

^j GLAXOSMITHKLINE   (Germany)

^k UNIVERSITY OF GLASGOW   (United Kingdom)

^l JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

4 OCTYL ITACONATE; CHEMICAL COMPOUND; CYSTEINE; INTERFERON; ITACONIC ACID; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BETA INTERFERON; CYTOKINE; HYDROLYASE; IRG1 PROTEIN, HUMAN; IRG1 PROTEIN, MOUSE; KEAP1 PROTEIN, HUMAN; KEAP1 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE; PROTEIN; SUCCINIC ACID DERIVATIVE;

ANTIOXIDANT; BACTERIOPHAGE; GENE EXPRESSION; METABOLITE; POLYSACCHARIDE; PROTEIN;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MACROPHAGE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESIDUE ANALYSIS; SEPSIS; AGONISTS; ANIMAL; BIOSYNTHESIS; BOVINE; CHEMISTRY; DRUG EFFECT; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; PHYSIOLOGICAL FEEDBACK; WISTAR RAT;

ALKYLATION; ANIMALS; ANTI-INFLAMMATORY AGENTS; CATTLE; CYSTEINE; CYTOKINES; FEEDBACK, PHYSIOLOGICAL; FEMALE; HEK293 CELLS; HUMANS; HYDRO-LYASES; INTERFERON-BETA; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-E2-RELATED FACTOR 2; PROTEINS; RATS; RATS, WISTAR; SUCCINATES;

EID: 85045147264     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature25986     Document Type: Article

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