Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels

Journal of Biological Chemistry

Volumn 291, Issue 27, 2016, Pages 14274-14284

  Cordes, Thekla ^a   Wallace, Martina ^a   Michelucci, Alessandro ^d,e   Divakaruni, Ajit S ^b   Sapcariu, Sean C ^e   Sousa, Carole ^d,e   Koseki, Haruhiko ^f   Cabrales, Pedro ^a   Murphy, Anne N ^b   Hiller, Karsten ^e   Metallo, Christian M ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^e UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^f RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRON TRANSPORT PROPERTIES; ENZYME ACTIVITY; GENES; IMMUNE SYSTEM; MACROPHAGES; METABOLISM;

ACTIVATED MACROPHAGES; ELECTRON TRANSPORT CHAIN; INFLAMMATORY RESPONSE; INFLAMMATORY STIMULI; INNATE IMMUNE RESPONSE; SUCCINATE DEHYDROGENASE; TRICARBOXYLIC ACID CYCLE; TRICARBOXYLIC ACIDS;

GENE EXPRESSION;

ITACONIC ACID; LIPOPOLYSACCHARIDE; SUCCINATE DEHYDROGENASE; TRICARBOXYLIC ACID; HYDROLYASE; IRG1 PROTEIN, MOUSE; SUCCINIC ACID; SUCCINIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL LEVEL; CELL METABOLISM; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNORESPONSIVE GENE 1; INNATE IMMUNITY; MACROPHAGE; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY CHAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL LINE; HYDRO-LYASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; SUCCINATE DEHYDROGENASE; SUCCINATES; SUCCINIC ACID;

EID: 84976869322     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.685792     Document Type: Article

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