Omega-6 fats for the primary and secondary prevention of cardiovascular disease

Cochrane Database of Systematic Reviews

Volumn 2018, Issue 7, 2018, Pages

  Hooper, Lee ^a   Al Khudairy, Lena ^b   Abdelhamid, Asmaa S ^a   Rees, Karen ^b   Brainard, Julii S ^a   Brown, Tracey J ^a   Ajabnoor, Sarah M ^a   O'Brien, Alex T ^a   Winstanley, Lauren E ^a   Donaldson, Daisy H ^a   Song, Fujian ^a   Deane, Katherine H O ^c  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL; DIROLEUTON; GAMMA LINOLENIC ACID; HIGH DENSITY LIPOPROTEIN; LINOLEIC ACID; LIPID; LOW DENSITY LIPOPROTEIN; OMEGA 6 FATTY ACID; TRIACYLGLYCEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ALL CAUSE MORTALITY; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CHOLESTEROL BLOOD LEVEL; DATA BASE; DIETARY INTAKE; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR ADVERSE CARDIAC EVENT; OBESITY; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SECONDARY PREVENTION; SYSTEMATIC REVIEW; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; ADULT; AGED; BLOOD; CAUSE OF DEATH; CEREBROVASCULAR DISEASE; FEMALE; MALE; META ANALYSIS; MIDDLE AGED; MORTALITY; PROCEDURES;

ADULT; AGED; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; CEREBROVASCULAR DISORDERS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FATTY ACIDS, OMEGA-6; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PRIMARY PREVENTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SECONDARY PREVENTION; TRIGLYCERIDES;

EID: 85050023952     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD011094.pub3     Document Type: Review

References (233)

1. Bates D, Fawcett PR, Shaw DA, Weightman D. Trial of polyunsaturated fatty acids in non-relapsing multiple sclerosis. British Medical Journal 1977;2(6092):932-3. 8887927
2. Dworkin RH, Bates D, Millar JH, Paty DW. Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. Neurology 1984;34(11):1441-5. 8887928
3. Bates D, Fawcett PR, Shaw DA, Weightman D. Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis. British Medical Journal 1978;2(6149):1390-1. 8887930
4. Dworkin RH, Bates D, Millar JH, Paty DW. Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. Neurology 1984;34(11):1441-5. 8887931
5. Belch JJ, Ansell D, Madhok R, O'Dowd A, Sturrock RD. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Annals of the Rheumatic Diseases 1988;47(2):96-104. 8887933
6. Black HS, Herd JA, Goldberg LH, Wolf-JE J, Thornby JI, Rosen T, et al. Effect of a low-fat diet on the incidence of actinic keratosis. New England Journal of Medicine 1994;330(18):1272-5. 8887935
7. Black HS, Thornby JI, Wolf-JE J, Goldberg LH, Herd JA, Rosen T, et al. Evidence that a low-fat diet reduces the occurrence of non-melanoma skin cancer. International Journal of Cancer 1995;62(2):165-9. 8887936
8. Jaax S, Scott LW, Wolf-JE J, Thornby JI, Black HS. General guidelines for a low-fat diet effective in the management and prevention of nonmelanoma skin cancer. Nutrition and Cancer 1997;27(2):150-6. 8887937
9. Burr ML, Fehily AM. Fish and the heart. Lancet 1989;ii:1450-2. 8887941
10. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989;2(8666):757-61. 8887939
11. Burr ML, Fehily AM, Rogers S, Welsby E, King S, Sandham S. Diet and reinfarction trial (DART): design, recruitment, and compliance. European Heart Journal 1989;10(6):558-67. 8887940
12. Burr ML, Holliday RM, Fehily AM, Whitehead PJ. Haematological prognostic indices after myocardial infarction: evidence from the diet and reinfarction trial (DART). European Heart Journal 1992;13(2):166-70. 8887942
13. Burr ML, Sweetham PM, Fehily AM. Diet and reinfarction (letter). European Heart Journal 1994;15(8):1152-3. 8887943
14. Fehily AM, Vaughan-Williams E, Shiels K, Williams AH, Horner M, Bingham G, et al. The effect of dietary advice on nutrient intakes: evidence from the diet and reinfarction trial (DART). Journal of Human Nutrition & Dietetics 1989;2(4):225-5. 8887944
15. Dullaart RP, Beusekamp BJ, Meijer S, Hoogenberg K, van Doormaal JJ, Sluiter WJ. Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion. Diabetologia 1992;35(2):165-72. [PUBMED: 1547922]8887946
16. Keen H, Payan J, Allawi J, Walker J, Jamal GA, Weir AI, et al. Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multicenter Trial Group. Diabetes Care 1993;16(1):8-15. 8887948
17. Houtsmuller AJ, Zahn KJ, Henkes HE. Unsaturated fats and progression of diabetic retinopathy. Documenta Ophthalmologia 1979;48(2):363-71. 8887950
18. Houtsmuller AJ, van Hal-Ferwerda J, Zahn KJ, Henkes HE. Favourable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy. Nutrition and Metabolism 1980;24(Suppl 1):105-18. 8887951
19. Houtsmuller AJ, van Hal-Ferwerda J, Zahn KJ, Henkes HE. Influence of different diets on the progression of diabetic retinopathy. Progress in Food Nutritition and Science 1980;4(5):41-6. 8887952
20. Mansel RE, Gateley CA, Harrison BJ, Melhuish J, Sheridan W, Pye JK, et al. Effects and tolerability of n-6 essential fatty acid supplementation in patients with recurrent breast cysts -- a randomized double-blind placebo-controlled trial. Journal of Nutritional Medicine 1990;1(3):195. 8887954
21. Mansel RE, Harrison BJ, Melhuish J, Sheridan W, Pye JK, Pritchard G, et al. A randomized trial of dietary intervention with essential fatty acids in patients with categorized cysts. Annals of the New York Academy of Sciences 1990;586:288-94. 8887955
22. Mansel RE, Pye JK, Hughes LE. Effects of essential fatty acids on cyclical mastalgia and noncyclical breat disorders. In: Horrobin DE editor(s). Omega-6 Essential Fatty Acids: Pathophysiology and Roles in Clinical Medicine. New York: Wiley-Liss, 1990:557-66. 8887956
23. McIllmurray MB, Turkie W. Controlled trial of gamma linolenic acid in Duke's C colorectal cancer. British Medical Journal (Clinical research ed.) 1987;294(6582):1260 (correction BMJ 1987;295(6596):475). 8887958
24. Mendis S, Samarajeewa U, Thattil RO. Coconut fat and serum lipoproteins: effects of partial replacement with unsaturated fats. British Journal of Nutrition 2001;85(5):583-9. 2912161
25. Ederer F, Leren P, Turpeinen O, Frantz ID Jr. Cancer among men on cholesterol lowering diets: experience of five clinical trials. Lancet 1971;2:203-6. 8887960
26. Heady JA. Are PUFA harmful?. British Medical Journal 1974;1(898):115-6. 8887961
27. MRC. Controlled trial of soya-bean oil in myocardial infarction. Lancet 1968;2(570):693-9. 8887962
28. Anon. The National Diet-Heart Study. Nutrition Reviews 1968;26(5):133-6. 8887964
29. Baker BM, Frantz ID Jr, Keys A, Kinsell LW, Page IH, Stamler J, et al. The National Diet-Heart Study: an initial report. JAMA 1963;185:105-6. 8887965
30. Brown HB. The National Diet Heart Study - implications for dietitians and nutritionists. Journal of the American Dietetic Association 1968;52:279-87. 8887966
31. Ederer F, Leren P, Turpeinen O, Frantz ID Jr. Cancer among men on cholesterol-lowering diets: Eperience from five clinical trials. Lancet 1971;298(7717):203-6. 8887967
32. NDHS Research Group. The National Diet-Heart Study final report. Circulation 1968;37(II):1-428. 8887968
33. Page IH, Brown HB. Some observations on the National Diet-Heart Study. Circulation 1968;37:313-5. 8887969
34. Anon. The National Diet-Heart Study. Nutrition Reviews 1968;26(5):133-6. 8887971
35. Baker BM, Frantz ID Jr, Keys A, Kinsell LW, Page IH, Stamler J, et al. The National Diet-Heart Study: An initial report. JAMA 1963;185:105-6. 8887972
36. Brown HB. The National Diet Heart Study - implications for dietitians and nutritionists. Journal of the American Dietetic Association 1968;52:279-87. 8887973
37. Ederer F, Leren P, Turpeinen O, Frantz ID Jr. Cancer among men on cholesterol-lowering diets: Eperience from five clinical trials. Lancet 1971;298(7717):203-206. 8887974
38. NDHS Research Group. The National Diet-Heart Study final report. Circulation 1968;37(II):1-428. 8887975
39. Page IH, Brown HB. Some observations on the National Diet-Heart Study. Circulation 1968;37:313-5. 8887976
40. Rose GA, Thomson WB, Williams RT. Corn oil in treatment of ischaemic heart disease. British Medical Journal 1965;1(5449):1531-3. [PUBMED: 14288105]8887978
41. Schirmer MA, Phinney SD. Gamma-linolenate reduces weight regain in formerly obese humans. Journal of Nutrition 2007;137(6):1430-5. [PUBMED: 17513402]8887980
42. Blacket RB, Leelarthaepin B, McGilchrist C, Palmer AJ, Woodhill JM. The synergistic effect of weight loss and changes in dietary lipids on the serum cholesterol of obese men with hypercholesterolaemia: implications for prevention of coronary heart disease. Australian and New Zealand Journal of Medicine 1979;9:521-9. 8887982
43. Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. (Erratum appears in BMJ. 2013;346:f903). BMJ 2013;346:e8707. 8887983
44. Woodhill JM, Palmer AJ, Leelarthaepin B, McGilchrist C, Blacket RB. Low fat, low cholesterol diet in secondary prevention of coronary heart disease. Advances in Experimental Medicine and Biology 1978;109:317-30. 8887984
45. Dayton S, Hashimoto S, Dixon W, Pearce ML. Composition of lipids in human serum and adipose tissue during prolonged feeding of a diet high in unsaturated fat. Journal of Lipid Research 1966;7:103-11. 8887986
46. Dayton S, Hashimoto S, Pearce ML. Adipose tissue linoleic acid as a criterion of adherence to a modified diet. Journal of Lipid Research 1967;8:508-10. 8887987
47. Dayton S, Hashimoto S, Pearce ML. Influence of a diet high in unsaturated fat upon composition of arterial tissue and atheromata in man. Circulation 1965;32:911-24. 8887988
48. Dayton S, Hashimoto S, Rosenblum D, Pearce M. Vitamin E status of humans during prolonged feeding of unsaturated fats. Journal of Laboratory and Clinical Medicine 1965;65(5):739-47. 8887989
49. Dayton S, Pearce ML. Diet and atherosclerosis. Lancet 1970;1(644):473-4. 8887993
50. Dayton S, Pearce ML. Diet and cardiovascular diseases. Lancet 1969;1(584):51-2. 8887994
51. Dayton S, Pearce ML. Diet high in unsaturated fat: a controlled clinical trial. Minnesota Medicine 1969;1969:1237-42. 8887995
52. Dayton S, Pearce ML. Prevention of coronary heart disease and other complications of atherosclerosis by modified diet. American Journal of Medicine 1969;46:751-62. 8887996
53. Dayton S, Pearce ML. Trial of unsaturated-fat diet. Lancet 1968;2(581):1296-7. 8887997
54. Dayton S, Pearce ML, Goldman H, Harnish A, Plotkin D, Shickman M, et al. Controlled trial of a diet high in unsaturated fat for prevention of atherosclerotic complications. Lancet 1968;2(577):1060-2. 8887990
55. Dayton S, Pearce ML, Hashimoto S, Dixon WJ, Tomayasu U. A controlled clinical trial of a diet high in unsaturated fat in preventing complications of atherosclerosis. Circulation 1969;15(1, Suppl 2):II-1-63. 8887991
56. Dayton S, Pearce ML, Hashimoto S, Fakler LJ, Hiscock E, Dixon WJ. A controlled clinical trial of a diet high in unsaturated fat. New England Journal of Medicine 1962;266:1017-23. 8887992
57. Ederer F, Leren P, Turpeinen O, Frantz ID Jr. Cancer among men on cholesterol-lowering diets: experience from five clinical trials. Lancet 1971;298(7717):203-206. 8887998
58. Hiscock E, Dayton S, Pearce ML, Hashimoto S. A palatable diet high in unsaturated fat. Journal of the American Dietetic Association 1962;40:427-31. 8887999
59. Pearce ML, Dayton S. Incidence of cancer in men on a diet high in polyunsaturated fat. Lancet 1971;1(697):464-7. 8888000
60. Sturdevant RA, Pearce ML, Dayton S. Increased prevalence of cholelithiasis in men ingesting a serum-cholesterol-lowering diet. New England Journal of Medicine 1973;288(1):24-7. 8888001
61. Tompkins MJ, Dayton S, Pearce ML. Effect of long-term feeding of various fats on whole blood clotting times in men. Journal of Laboratory and Clinical Medicine 1964;64(5):763-72. 8888002
62. Nandakumar S, Vijayakumar M, Krishnan S. Coconut oil vs sunflower oil in atherosclerosis. Challenges in dietary intervention. Indian Heart Journal 2014;66:S11. 8888004
63. Vijayakumar M, Krishnaan S, Sundram KR, Vasudevan DM, Nandakumar S. What oil in patients with established coronary artery disease-outcomes of two year dietary intervention with coconut oil & sunflower oil. Indian Heart Journal 2014;66:S12. 8888005
64. Vijayakumar M, Vasudevan DM, Sundaram KR, Krishnan S, Vaidyanathan K, Nandakumar S, et al. A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease. Indian Heart Journal 2016;68:498-506. [DOI: 10.1016/j.ihj.2015.10.384]8888006
65. Bierenbaum ML, Green DP, Gherman C, Florin A, Caidwell AB. The effects of two low fat dietary patterns on the blood cholesterol level of young male coronary patients. Journal of Chronic Diseases 1963;16(10):1073-83. 8888008
66. Bramkamp K, Wirths W. Influence of linoleic acid enriched margarine on serum cholesterol levels in the elderly [Über den Einfluß von linolsäurereicher Margarine auf den Serumcholesterinspiegel älterer Menschen]. Zeitschrift für Ernährungswissenschaft 1974;13(1-2):59-68. 2912052
67. Dembinska-Kiec A, Malczewska-Malec M, Roche H, Leszczynska-Golabek I, Hartwich J, Wybranska I, et al. The effect of the n-3/n-6 PUFA ratio on the transformation of postprandial state proatherogenic LDL phenotype and oxidative stress parameters. Atherosclerosis Supplements 2010;11(2):129-30. 2912074
68. Dembinska-Kiec A, Malczewska-Malec M, Hartwich J, Wnek D, Goralska J, Kiec-Wilk B, et al. The effect of dietary intervention on proatherogenic profile of lipoproteins and the blood oxidative stress parameters measured in the course of postprandial lipemia: Lipgene study. Journal of Diabetes 2011;3(s1):28. 2912076
69. Elisha B, Guebre-Egziabher F, Vidal H, Bastard J, Laville M, Rabasa-Lhoret R. From French to Mediterranean diet: importance of the omega-6/omega-3 fatty acids ratio. World Review of Nutrition and Dietetics 2011;102:81-91. 2912078
70. Finnegan YE, Howarth D, Minihane AM, Kew S, Miller GJ, Calder PC, et al. Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. Journal of Nutrition 2003;133(7):2210-3. 2912082
71. Finnegan YE, Minihane AM, Leigh-Firbank EC, Kew S, Meijer GW, Muggli R, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. American Journal of Clinical Nutrition 2003;77(4):783-95. 2912084
72. Miettinen M, Turpeinen O, Karvonen MJ, Elosuo R, Paavilainen E. Effect of cholesterol-lowering diet on mortality from coronary heart-disease and other causes: a twelve-year clinical trial in men and women. Lancet 1972;2(782):835-8. 8888010
73. Miettinen M, Turpeinen O, Karvonen MJ, Pekkarinen M, Paavilainen E, Elosuo R. Dietary prevention of coronary heart disease in women: the Finnish mental hospital study. International Journal of Epidemiology 1983;12(1):17-25. 8888011
74. Turpeinen O, Miettinen M, Karvonen M, Roine P, Pekkarinen M, Lehtosuo EJ, et al. Dietary prevention of coronary heart disease: long-term experiment. I. Observations on male subjects. American Journal of Clinical Nutrition 1968;21(4):255-76. 8888012
75. Gaullier JM, Halse J, Høye K, Kristiansen K, Fagertun H, Vik H, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition 2004;79(6):1118-25. 2912088
76. Gaullier JM, Halse J, Høye K, Kristiansen K, Fagertun H, Vik H, et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. Journal of Nutrition 2005;135(4):778-84. 2912090
77. Gaullier JM, Halse J, Høivik HO, Høye K, Syvertsen C, Nurminiemi M, et al. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. British Journal of Nutrition 2007;97(3):550-60. 2912092
78. Ghafoorunissa, Reddy V, Sesikaran B. Palmolein and groundnut oil have comparable effects on blood lipids and platelet aggregation in healthy Indian subjects. Lipids 1995;30(12):1163-9. 2912094
79. Ghafoorunissa, Vani A, Laxmi R, Sesikeran B. Effects of dietary alpha-linolenic acid from blended oils on biochemical indices of coronary heart disease in Indians. Lipids 2002;37(11):1077-86. 2912096
80. Harbige LS, Sharief MK. Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis. British Journal of Nutrition 2007;98(Suppl 1):S46-53. 8888014
81. Harris WS, Mozaffarian D, Rimm E, Kris-Etherton P, Rudel LL, Appel LJ, et al. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 2009;119(6):902-7. 2912108
82. Heine RJ, Mulder C, Popp-Snijders C, van der Meer J, van der Veen EA. Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients. American Journal of Clinical Nutrition 1989;49(3):448-56. 2912114
83. Hui R, St-Louis J, Falardeau P. Anti-hypertensive properties of linoleic acid and fish oil omega-3 fatty acids independent of the prostaglandin system. American Journal of Hypertension 1989;2(8):610-7. 2912124
84. Dyer O. News Roundup: GMC reprimands doctor for research fraud. BMJ 2003;326:730. [DOI: 10.1136/bmj.326.7392.730/a]8888016
85. Jamal GA, Carmichael H. The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. Diabetic Medicine 1990;7(4):319-23. 8888017
86. Khan F, Elherik K, Bolton-Smith C, Barr R, Hill A, Murrie I, et al. The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovascular Research 2003;59(4):955-62. 2912132
87. Kruger MC, Coetzer H, de Winter R, Gericke G, Van Papendorp DH. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Aging-Clinical & Experimental Research 1998;10(5):385-94. 8888019
88. Lands WE, Libelt B, Morris A, Kramer NC, Prewitt TE, Bowen P, et al. Maintenance of lower proportions of (n-6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n-3) fatty acids. Biochimica et Biophysica Acta 1992;1180(2):147-62. 2912146
89. Larsen TM, Toubro S, Gudmundsen O, Astrup A. Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. American Journal of Clinical Nutrition 2006;83(3):606-12. 8888021
90. Leng GC, Lee AJ, Fowkes FG, Jepson RG, Lowe GD, Skinner ER, et al. Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease. Clinical Nutrition 1998;17(6):265-71. 8888023
91. Ley SJ, Metcalf PA, Scragg RKR, Swinburn BA. Long-term effects of a reduced fat diet intervention on cardiovascular disease risk factors in individuals with glucose intolerance. Diabetes Research and Clinical Practice 2004;63:103-12. 8888025
92. Swinburn BA, Metcalf PA, Ley SJ. Long-term (5-year) effects of a reduced-fat diet intervention in individuals with glucose intolerance. Diabetes Care 2001;24(4):619-24. 8888026
93. Swinburn BA, Woollard GA, Chang EC, Wilson MR. Effects of reduced-fat diets consumed ad libitum on intake of nutrients particularly antioxidant vitamins. Journal of the American Dietetic Association 1999;99(11):1400-5. 8888027
94. Bemelmans WJ, Broer J, Feskens EJ, Smit AJ, Muskiet FA, Lefrandt JD, et al. Effect of an increased intake of α-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. American Journal of Clinical Nutrition 2002;75(2):221-7. 2912152
95. Bemelmans WJ, Broer J, de Vries JH, Hulshof KF, May JF, Meyboom-de Jong B. Impact of Mediterramean diet education versus posted leaflet on dietary habits and serum cholesterol in a high risk population for cardiovascular disease. Public Health Nutrition 2000;3(3):273-83. 2912153
96. Bemelmans WJ, Lefrandt JD, Feskens EJ, van Haelst PL, Broer J, Meyboom-de Jong B, et al. Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. European Journal of Clinical Nutrition 2004;58(7):1083-9. 8888028
97. Bemelmans WJ, Muskiet FA, Feskens EJ, de Vries JH, Broer J, May JF, et al. Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease. European Journal of Clinical Nutrition 2000;54(12):865-71. 8888029
98. Michalsen A, Lehmann N, Pithan C, Knoblauch NT, Moebus S, Kannenberg F, et al. Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery disease. European Journal of Clinical Nutrition 2006;60(4):478-85. 8888031
99. Middleton SJ, Naylor S, Woolner J, Hunter JO. A double-blind, randomized, placebo-controlled trial of essential fatty acid supplementation in the maintenance of remission of ulcerative colitis. Alimentary Pharmacology and Therapeutics 2002;16(6):1131-5. [PUBMED: 12030955]8888033
100. Millar JH, Zilkha KJ, Langman MJ, Wright HP, Smith AD, Belin J, et al. Double-blind trial of linoleate supplementation of the diet in multiple sclerosis. British Medical Journal 1973;1(5856):765-8. 8888035
101. Brewer ER, Ashman PL, Kuba K. The Minnesota Coronary Survey: composition of diets, adherence and serum lipid response. Circulation 1975;51 and 52(Suppl II):269. 8888037
102. Dawson EA, Gatewood LC. The Minnesota Coronary Survey: methodology and characteristics of the population. Circulation 1975;51 and 52(Suppl II):271. 8888038
103. Frantz ID Jr, Dawson EA, Ashman PL, Gatewood LC, Bartsch GE, Kuba K, et al. Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey. Arteriosclerosis 1989;9(1):129-35. 8888039
104. Frantz ID, Dawson EA, Kuba K, Brewer ER, Gatewood LC, Bartsch GE. The Minnesota Coronary Survey: effect of diet on cardiovascular events and deaths. Circulation 1975;51 and 52(Suppl II):4. 8888040
105. Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, et al. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ 2016;353:i1246. 8888041
106. Moy TF, Yanek LR, Raqueno JV, Bezirdjian PJ, Blumenthal RS, Wilder LB, et al. Dietary counselling for high blood cholesterol in families at risk of coronary disease. Preventive Cardiology 2001;4(4):158-64. 8888043
107. Ederer F, Leren P, Turpeinen O, Frantz ID Jr. Cancer among men on cholesterol lowering diets: experience of five clinical trials. Lancet 1971;2:203-6. 8888045
108. Leren P. The Oslo diet-heart study. Eleven-year report. Circulation 1970;42(5):935-42. 8888046
109. Leren P. The effect of plasma cholesterol lowering diet in male survivors of myocardial infarction. A controlled clinical trial. Acta Medica Scandinavica. Supplementum 1966;466:1-92. 8888047
110. Leren P. The effect of plasma-cholesterol-lowering diet in male survivors of myocardial infarction: a controlled clinical trial. Bulletin of the New York Academy of Medicine 1968;44:1012-21. 8888048
111. Coppack SW, Doll HA, Pim B, Hockaday TDR. Intravenous glucose tolerance and mortality in non-insulin-dependant diabetes mellitus. Quarterly Journal of Medicine 1990;75:451-60. 8888050
112. Hillson RM, Hockaday TDR, Mann JI, Newton DJ. Hyperinsulinaemia is associated with development of ECG abnormalities in diabetics. Diabetes Research 1984;1:143-9. 8888051
113. Hockaday TD, Hockaday JM, Mann JI, Turner RC. Prospective comparison of modified fat-high-carbohydrate with standard low-carbohydrate dietary advice in the treatment of diabetes: one year follow-up study. British Journal of Nutrition 1978;39(2):357-62. 8888052
114. Howard-Williams J, Patel P, Jelfs R, Carter RD, Awdry P, Bron A, et al. Polyunsaturated fatty acids and diabetic retinopathy. British Journal of Ophthalmology 1985;69(1):15-8. 8888053
115. Lopez-Espinoza I, Howard WJ, Mann JI, Carter RD, Hockaday TD. Fatty acid composition of platelet phospholipids in non-insulin-dependent diabetics randomized for dietary advice. British Journal of Nutrition 1984;52(1):41-7. 8888054
116. Olendzki BC, Leung K, Van Buskirk S, Reed G, Zurier RB. Treatment of rheumatoid arthritis with marine and botanical oils: influence on serum lipids. Evidence-Based Complementary & Alternative Medicine: eCAM 2011;2011:827286. 8888056
117. Reed GW, Leung K, Rossetti RG, Vanbuskirk S, Sharp JT, Zurier RB. Treatment of rheumatoid arthritis with marine and botanical oils: an 18-month, randomized, and double-blind trial. Evidence-Based Complementary & Alternative Medicine: eCAM 2014;2014:857456. 8888057
118. Roche H, Ferguson JF, Perez-Martinez P, Lovegrove JA, Drevon CA, Defoort C, et al. Dietary fats, inflammation and insulin resistance-insights from the lipgene study. Atherosclerosis Supplements 2009;10:2. 2912221
119. Djuric Z, Heilbrun LK, Reading BA, Boomer A, Valeriote FA, Martino S. Effects of a low fat diet on levels of oxidative damage to DNA in human peripheral nucleated blood cells. Journal of the National Cancer Institute 1991;83(11):766-9. 8888059
120. Djuric Z, Martino S, Heilbrun LK, Hart RW. Dietary modulation of oxidative DNA damage. Advances In Experimental Medicine and Biology 1994;354:71-83. 8888060
121. Kasim SE, Martino S, Kim P-N, Khilnani S, Boomer A, Depper J, et al. Dietary and anthropometric determinants of plasma lipoproteins during a long-term low-fat diet in healthy women. American Journal of Clinical Nutrition 1993;57:146-53. 8888061
122. Simon MS, Heilbrun LK, Boomer A, Kresge C, Depper J, Kim PN, et al. A randomised trial of a low-fat dietary intervention in women at high risk for breast cancer. Nutrition and Cancer 1997;27(2):136-42. 8888062
123. Sluijs I, Plantinga Y, de Roos B, Mennen LI, Bots ML. Dietary supplementation with cis-9, trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults. American Journal of Clinical Nutrition 2010;91(1):175-83. 2912016
124. Blann AD, Jackson P, Bath PM, Watts GF. von Willebrand factor, a possible indicator of endothelial cell damage, decreases during long-term compliance with a lipid-lowering diet. Journal of Internal Medicine 1995;237:557-61. 8888064
125. Watts GF. Nutritional, metabolic, and genetic determinants of the progression of coronary heart disease. STARS Group. Journal of Cardiovascular Pharmacology 1995;25(Suppl 4):S11-9. 8888073
126. Watts GF, Brunt JNH, Coltart DJ, Lewis B. The St. Thomas Atherosclerosis Regression Study (STARS). Atherosclerosis 1992;97:231. 8888065
127. Watts GF, Jackson P, Burke V, Lewis B. Dietary fatty acids and progression of coronary artery disease in men. American Journal of Clinical Nutrition 1996;64:202-9. 8888066
128. Watts GF, Jackson P, Mandalia S, Brunt JN, Lewis ES, Coltart DJ, et al. Nutrient intake and progression of coronary artery disease. American Journal of Cardiology 1994;73(5):328-32. 8888067
129. Watts GF, Lewis B, Brunt JN, Lewis ES, Coltart DJ, Smith LD, et al. Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS). Lancet 1992;339(8793):563-9. 8888068
130. Watts GF, Lewis B, Brunt JNH, Swan AV. Coronary Atheroma Regression Trials. Lancet 1992;339(i):1241-3. 8888069
131. Watts GF, Lewis B, Jackson P, Burke V, Lewis ES, Brunt JN, et al. Relationships between nutrient intake and progression/regression of coronary atherosclerosis as assessed by serial quantitative angiography. Canadian Journal of Cardiology 1995;11(Suppl G):110G-4G. 8888070
132. Watts GF, Mandalia S, Brunt JN, Slavin BM, Coltart DJ, Lewis B. Independent associations between plasma lipoprotein subfraction levels and the course of coronary artery disease in the St. Thomas' Atherosclerosis Regression Study (STARS). Metabolism: Clinical and Experimental 1993;42:1461-7. 8888071
133. Watts GF, Mandalia S, Slavin BM, Brunt JN, Coltart DJ, Lewis B. Metabolic determinants of the course of coronary artery disease in men. Clinical Chemistry 1994;40(12):2240-6. 8888072
134. Van der Merwe CF, Booyens J, Joubert HF, van der Merwe CA. The effect of gamma-linolenic acid, an in vitro cytostatic substance contained in evening primrose oil, on primary liver cancer. A double-blind placebo controlled trial. Prostaglandins Leukotrienes and Essential Fatty Acids 1990;40:199-202. 8888075
135. Vergroesen AJ, de Deckere EA, ten Hoor F, Hornstra G. Cardiovascular effects of linoleic acid. Progress in Food & Nutrition Science 1980;4(5):13-25. 2912267
136. Anderson G, Cummings S, Freedman LS, Furberg C, Henderson M, Johnson SR, et al. Design of the Women's Health Initiative clinical trial and observational study. Controlled Clinical Trials 1998;19(1):61-109. 8888077
137. Anderson GL, Manson J, Wallace R, Lund B, Hall D, Davis S, et al. Implementation of the Women's Health Initiative study design. Annals of Epidemiology 2003;13(9 Suppl):S5-17. 8888078
138. Beresford SA, Johnson KC, Ritenbaugh C, Lasser NL, Snetselaar LG, Black HR, et al. Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295(6):643-54. 8888079
139. Bowen D, Ehret C, Pedersen M, Snetselaar L, Johnson M, Tinker L, et al. Results of an adjunct dietary intervention program in the Women's Health Initiative. Journal of the American Dietetic Association 2002;102(11):1631-7. 8888080
140. Carty CL, Kooperberg C, Neuhouser ML, Tinker L, Howard B, Wactawski-Wende J, et al. Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial. American Journal of Clinical Nutrition 2011;93:516-24. 8888081
141. Curb JD, McTiernan A, Heckbert SR, Kooperberg C, Stanford J, Nevitt M, et al. Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Annals of Epidemiology 2003;13(9 Suppl):S122-8. 8888082
142. Hays J, Hunt JR, Hubbell FA, Anderson GL, Limacher M, Allen C, et al. The Women's Health Initiative recruitment methods and results. Annals of Epidemiology 2003;13(9 Suppl):S18-77. 8888083
143. Hebert JR, Patterson RE, Gorfine M, Ebbeling CB, St Jeor ST, Chlebowski RT, et al. Differences between estimated caloric requirements and self-reported caloric intake in the women's health initiative. Annals of Epidemiology 2003;13(9):629-37. 8888084
144. Howard BV. Dietary fat and cardiovascular disease: putting the Women's Health Initiative in perspective. Nutrition Metabolism & Cardiovascular Diseases 2007;17(3):171-4. 8888087
145. Howard BV, Manson JE, Stefanick ML, Beresford SA, Frank G, Jones B, et al. Low-fat dietary pattern and weight change over 7 years: the Women's Health Initiative Dietary Modification Trial. JAMA 2006;295(1):39-49. 8888085
146. Howard BV, Van Horn L, Hsia J, Manson JE, Stefanick ML, Wassertheil-Smoller S, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295(6):655-66. 8888086
147. Neuhouser ML, Tinker L, Shaw PA, Schoeller D, Bingham SA, Horn LV, et al. Use of recovery biomarkers to calibrate nutrient consumption self-reports in the Women's Health Initiative. American Journal of Epidemiology 2008;167(10):1247-59. 8888088
148. Patterson RE, Kristal A, Rodabough R, Caan B, Lillington L, Mossavar-Rahmani Y, et al. Changes in food sources of dietary fat in response to an intensive low-fat dietary intervention: early results from the Women's Health Initiative. Journal of the American Dietetic Association 2003;103(4):454-60. 8888089
149. Patterson RE, Kristal AR, Tinker LF, Carter RA, Bolton MP, gurs-Collins T, et al. Measurement characteristics of the Women's Health Initiative food frequency questionnaire. Annals of Epidemiology 1999;9(3):178-87. 8888090
150. Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockene JK, et al. Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 2006;295(6):629-42. 8888091
151. Prentice RL, Thomson CA, Caan B, Hubbell FA, Anderson GL, Beresford SA, et al. Low-fat dietary pattern and cancer incidence in the Women's Health Initiative Dietary Modification Randomized Controlled Trial. Journal of the National Cancer Institute 2007;99(20):1534-43. 8888092
152. Ritenbaugh C, Patterson RE, Chlebowski RT, Caan B, Fels-Tinker L, Howard B, et al. The Women's Health Initiative Dietary Modification trial: overview and baseline characteristics of participants. Annals of Epidemiology 2003;13(9 Suppl):S87-97. 8888093
153. Robinson JG, Wallace R, Safford MM, Pettinger M, Cochrane B, Ko MG, et al. Another treatment gap: restarting secondary prevention medications: the Women's Health Initiative. Journal of Clinical Lipidology 2010;4:36-45. 8888094
154. Rossouw JE, Finnegan LP, Harlan WR, Pinn VW, Clifford C, McGowan JA. The evolution of the Women's Health Initiative: perspectives from the NIH. Journal of the American Medical Women's Association 1995;50(2):50-5. 8888095
155. The Women's Health Initiative Study Group. Design of the Women's Health Initiative clinical trial and observational study. Controlled Clinical Trials 1998;19(1):61-109. 8888096
156. Tinker LF, Bonds DE, Margolis KL, Manson JE, Howard BV, Larson J, et al. Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial. Archives of Internal Medicine 2008;168(14):1500-11. 8888097
157. Tinker LF, Perri MG, Patterson RE, Bowen DJ, McIntosh M, Parker LM, et al. The effects of physical and emotional status on adherence to a low-fat dietary pattern in the Women's Health Initiative. Journal of the American Dietetic Association 2002;102(6):789-800. 8888098
158. Tinker LF, Rosal MC, Young AF, Perri MG, Patterson RE, Van Horn L, et al. Predictors of dietary change and maintenance in the Women's Health Initiative Dietary Modification Trial. Journal of the American Dietetic Association 2007;107(7):1155-66. 8888099
159. Women's Health Initiative Study Group. Dietary adherence in the Women's Health Initiative Dietary Modification Trial. Journal of the American Dietetic Association 2004;104(4):654-8. 8888100
160. Chlebowski RT, Blackburn GL, Buzzard IM, Rose DP, Martino S, Khandekar JD, et al. Adherence to a dietary fat intake reduction program in postmenopausal women receiving therapy for early breast cancer. The Women's Intervention Nutrition Study. Journal of Clinical Oncology 1993;11(11):2072-80. 8888102
161. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, et al. Dietary fat reduction and breast cancer outcome: interim efficacy results from the women's intervention nutrition study. JNCI Journal of the National Cancer Institute 2006;98(24):1767-76. 8888103
162. Chlebowski RT, Rose DP, Buzzard IM, Blackburn GL, York M, Insull W, et al. Dietary fat reduction in adjuvant breast cancer therapy: current rationale and feasibility issues. Adjuvant. The Cancer Journal 1990;6:357-63. 8888104
163. Hoy MK, Winters BL, Chlebowski RT, Papoutsakis C, Shapiro A, Lubin MP, et al. Implementing a low-fat eating plan in the Women's Intervention Nutrition Study. Journal of the American Dietetic Association 2009;109(4):688-96. 8888105
164. Rose DP, Chlebowski RT, Connolly JM, Jones LA, Wynder EL. Effects of tamoxifen adjuvant therapy and a low-fat diet on serum binding proteins and estradiol bioavailability in postmenopausal breast cancer patients. Cancer Research 1992;52:5386-90. 8888106
165. Rose DP, Connolly JM, Chlebowski RT, Buzzard IM, Wynder EL. The effects of a low-fat dietary intervention and tamoxifen adjuvant therapy on the serum estrogen and sex hormone-binding globulin concentrations of postmenopausal breast cancer patients. Breast Cancer Research & Treatment 1993;27(3):253-62. 8888107
166. Wynder EL, Cohen LA, Winters BL. The challenges of assessing fat intake in cancer research investigations. Journal of the American Dietetic Association 1997;97(7 Suppl):S5-8. 8888108
167. Ziboh VA, Naguwa S, Vang K, Wineinger J, Morrissey BM, Watnik M, et al. Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. Clinical & Developmental Immunology 2004;11(1):13-21. 8888110
168. Chandrakala G, Arpana G, Rao PV. Long-term effects of a reduced fat diet intervention in pre-diabetes. 70th Scientific Sessions of the American Diabetes Association; 25-29 June 2010; Orlando (FL). 2010; Vol. professional.diabetes.org/meeting/scientific-sessions/70th-scientific-sessions-2010:195-PO. 8888112
169. Chandrakala G, Arpana G, Sreenivas T, Rao PV. Low-fat (<20%) diets prevent type 2 diabetes mellitus. Diabetes 2012;61:A190. 8888113
170. Abdelhamid A, Hooper L, Welch A. Polyunsaturated fatty acids for musculoskeletal health and functional status in older adults. PROSPERO 2017 CRD42017079211. Available from: www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017079211.
171. Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2018, Issue 6. [DOI: 10.1002/14651858.CD003177.pub3]
172. Abdelhamid AS, Martin N, Bridges C, Brainard JS, Wang X, Brown TJ, et al. Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2018, Issue 6. [DOI: 10.1002/14651858.CD012345.pub2]
173. Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ. Effect of lower sodium intake on health: systematic review and meta-analysis. BMJ 2013;346:F1326. [DOI: 10.1136/bmj.f1326]
174. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analysis. BMJ 2013;346:f1378. [DOI: 10.1136/bmj.f1378]
175. Australian Institute of Health and Welfare 2016. The burden of disease and injury in Australia 2011. www.aihw.gov.au/getmedia/d4df9251-c4b6-452f-a877-8370b6124219/19663.pdf.aspx?inline=true. Canberra: AIHW, (accessed 30 Sept 2017). [ISBN 978-1-74249-908-6 ]
176. Baylink DJ, Finkelman RD, Mohan S. Growth factors to stimulate bone formation. Journal of Bone and Mineral Research 1993;8:S565-72.
177. Berkley CS, Hoaglin DC, Mosteller F, Colditz GA. A random-effects regression model for meta-analysis. Statistics in Medicine 1995;14(4):395-411.
178. British Heart Foundation. Cardiovascular disease. www.bhf.org.uk/heart-health/conditions/cardiovascular-disease.aspx (accessed 30 Sept 2017).
179. Bibus D, Lands B. Balancing proportions of competing omega-3 and omega-6 highly unsaturated fatty acids (HUFA) in tissue lipids. Prostaglandins, Leukotrienes and Essential Fatty Acids 2015;99:19-23.
180. Brown T, Song F, Wang X, Brainard J, Hooper L. Dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus. PROSPERO 2017 CRD42017064110. Available from: www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017064110.
181. Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?. British Journal of Clinical Pharmacology 2013;75(3):645-62.
182. Chan AW, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004;291:2457-65.
183. Chan AW, Krleža-Jeric K, Schmid I, Altman DG. Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research. Canadian Medical Association Journal 2004;171:735-740.
184. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Annals of Internal Medicine 2014;160(6):398-406.
185. De Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, et al. Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ 2015;351:h3978. [DOI: 10.1136/bmj.h3978]
186. Eckel RH, Jakicic JM, Ard JD, Hubbard VS, de Jesus JM, Lee I-M, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129(25 Suppl 2):S76-99. [DOI: 10.1161/01.cir.0000437740.48606.d1]
187. Esrey KL, Joseph L, Grover SA. Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study. Journal of Clinical Epidemiology 1996;49(2):211-6.
188. Buckingham J, Fisher B, Saunders D. Evidence Based Medicine Toolkit. 2008. www.ebm.med.ualberta.ca/TherapyCalc.html (accessed 28 March 2018).
189. Farvid MS, Ding M, Pan A, Sun Q, Chiuve SE, Steffen LM, et al. Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. Circulation 2014;130(18):1568-78.
190. Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing epidemic of coronary heart disease in low- and middle-income countries. Current Problems in Cardiology 2010;35(2):72-115.
191. McMaster University (developed by Evidence Prime, Inc). GRADEpro GDT. Version accessed 30 September 2017. Hamilton (ON): McMaster University (developed by Evidence Prime, Inc), 2015.
192. Groff JL, Gropper SS, Hunt SM. Advanced Nutrition and Human Metabolism. 2nd Edition. New York: Wandsworth Publishing, 1995.
193. Hall WL. Dietary saturated and unsaturated fats as determinants of blood pressure and vascular function. Nutrition Research Reviews 2009;22(1):18-38.
194. Hanson S, Biswas P, Jimoh OF, O'Brien A, Hooper L, Abdelhamid A, et al. Dietary polyunsaturated fat for prevention and treatment of depression and anxiety. PROSPERO 2017 CRD42017056092. Available from: www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017056092.
195. Hanson S, Thorpe G, Winstanley L, Abdelhamid A, Hooper L. Effects of supplementary dietary polyunsaturated fat on cancer incidence. PROSPERO 2017 CRD42017056092. Available from: www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017056109.
196. Harris WS, Poston WC, Haddock CK. Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events. Atherosclerosis 2007;193(1):1-10.
197. He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC, et al. Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study. BMJ 2003;327(7418):777-82.
198. Higgins JP, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
199. Hooper L, Summerbell CD, Thompson R, Sills D, Roberts FG, Moore H, et al. Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database of Systematic Reviews 2011, Issue 7. [DOI: 10.1002/14651858.CD002137.pub2]
200. Hooper L, Martin N, Abdelhamid A, Davey Smith G. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database of Systematic Reviews 2015, Issue 6. [DOI: 10.1002/14651858.CD011737]
201. Hussein N, Ah-Sing E, Wilkinson P, Leach C, Griffin BA, Millward DJ. Long-chain conversion of (13C) linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. Journal of Lipid Research 2005;46:269-80.
202. Jimoh OF, Brainard J, Deane KA, Biswas P, Donaldson D, Hooper L. Dietary polyunsaturated fat for prevention and treatment of neurocognitive disorders. PROSPERO 2017 CRD42017019049. Available from: www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017019049.
203. Katan MB. Omega-6 polyunsaturated fatty acids and coronary heart disease. American Journal of Clinical Nutrition 2009;89(5):1283-4.
204. Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JP, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
205. McGee DL, Reed DM, Yano K, Kagan A, Tillotson J. Ten-year incidence of coronary heart disease in the Honolulu Heart Program: relationship to nutrient intake. American Journal of Epidemiology 1984;119(5):667-76.
206. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. American Journal of Clinical Nutrition 2003;77(5):1146-55.
207. Mensink RP. Effects of Saturated Fatty Acids on Serum Lipids and Lipoproteins: a Systematic Review and Regression Analysis. Geneva: World Health Organization, 2016.
208. Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLOS Medicine 2010;7(3):e1000252.
209. Medical Research Council. Cluster randomised trials: methodological and ethical considerations. MRC clinical trials series; 2002. www.cebma.org/wp-content/uploads/Cluster-randomised-trials-Methodological-and-ethical-considerations.pdf (accessed 28 March 2018).
210. Müller-Nordhorn J, Binting S, Roll S, Willich SN. An update on regional variation in cardiovascular mortality within Europe. European Heart Journal 2008;29(10):1316-26.
211. National Health Service. Atherosclerosis (arteriosclerosis). www.nhs.uk/conditions/atherosclerosis/pages/introduction.aspx (accessed 30 Sept 2017)).
212. Pietinen P, Ascherio P, Korhonen P, Hartman A, Willett WC, Albanes D, et al. Intake of fatty acids and risk of coronary heart disease in a cohort of Finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. American Journal of Epidemiology 1997;145(10):876-87.
213. Ramsden CE, Hibbeln JR, Majchrzak SF, Davis JM. N-6 Fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. British Journal of Nutrition 2010;104(11):1586-600.
214. Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, et al. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ 2016;353:i1246.
215. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
216. Rincón-Cervera M, Rodríguez-García I, Guil-Guerrero J. Purification of GLA-triglycerides from evening primrose oil by gravimetric column chromatography. Journal of the American Oil Chemists' Society 2009;86(7):605-9.
217. Roberts I, Ker K, Edwards P, Beecher D, Manno D, Sydenham E. The knowledge system underpinning healthcare is not fit for purpose and must change. BMJ 2015;350:h2463. [DOI: 10.1136/bmj.h2463]
218. Russo GL. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochemical Pharmacology 2009;77(6):937-46.
219. Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation 2017;136:e1-e23. [DOI: 10.1161/CIR.0000000000000510]
220. Savovic J, Jones H, Altman D, Harris R, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomised controlled trials: combined analysis of meta-epidemiological studies. Health Technology Assessment 2012;16:1-82.
221. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
222. Schünemann H, Brozek J, Guyatt G, Oxman A, editor(s). Handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach (updated October 2013). GRADE Working Group, 2013. Available from gdt.guidelinedevelopment.org/app/handbook/handbook.html.
223. Sharp S. Meta-analysis regression. Stata Technical Bulletin 1998;42:16-22.
224. Siriwardhana N, Kalupahana NS, Fletcher S, Xin W, Claycombe KJ, Quignard-Boulange A, et al. N-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-κB-dependent mechanisms. Journal of Nutritional Biochemisty 2012;23(12):1661-7. [DOI: 10.1016/j.jnutbio.2011.11.009]
225. Spagnoli L, Bonanno E, Sangiorgi G, Mauriello A. Role of inflammation in atherosclerosis. Journal of Nuclear Medicine 2007;48(11):1800-15.
226. Thorpe G, Ajabnoor S, Ahmed Z, Abdelhamid A, Hooper L. Dietary polyunsaturated fat for prevention and treatment of inflammatory bowel disease. Dietary polyunsaturated fat for prevention and treatment of inflammatory bowel disease. PROSPERO 2017 CRD42017068704. Available from: www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017068704.
227. Tortosa-Caparrós E, Navas-Carrillo D, Marín F, Orenes-Piñero E. Anti-inflammatory effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome. Critical Reviews in Food Science and Nutrition 2017;57(16):3421-9. [DOI: 10.1080/10408398.2015.1126549]
228. Joint WHO/FAO Expert Consultation on Diet, Nutrition and the Prevention of Chronic Diseases. Diet, nutrition and the prevention of chronic diseases: report of a joint WHO/FAO expert consultation. Geneva: World Health Organization; 2003. WHO technical report series: 916. [ISBN 92 4 120916 X; apps.who.int/iris/bitstream/10665/42665/1/WHO_TRS_916.pdf]
229. World Health Organization. Cardiovascular diseases (CVDs). Fact sheet number 317. www.who.int/mediacentre/factsheets/fs317/en (accessed 30 Sept 2017).
230. Wood L, Egger M, Gluud LL, Schulz K, Jüni P, Altman DG, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 2008;336:601-5.
231. Wu JHY, Marklund M, Imamura F, Tintle N, Ardisson KAV, de Goede J, et al. Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39740 adults from 20 prospective cohort studies. Lancet Diabetes & Endocrinology 2017;5(12):965-74. [DOI: 10.1016/S2213-8587(17)30307-8]
232. Al-Khudairy L, Hartley L, Clar C, Flowers N, Hooper L, Rees K. Omega 6 fatty acids for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2015;11:CD011094.
233. Hartley L, Clar C, Flowers N, Hooper L, Rees K. Omega 6 fatty acids for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2014, Issue 5. [DOI: 10.1002/14651858.CD011094]