Re-evaluation of the traditional diet-heart hypothesis: Analysis of Recovered data from Minnesota Coronary Experiment (1968-73)

BMJ (Online)

Volumn 353, Issue , 2016, Pages

  Ramsden, Christopher E ^a,b   Zamora, Daisy ^b   Majchrzak Hong, Sharon ^a   Faurot, Keturah R ^b   Broste, Steven K ^c   Frantz, Robert P ^d   Davis, John M ^b,e   Ringel, Amit ^a   Suchindran, Chirayath M ^f   Hibbeln, Joseph R ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Medtronic ^*  (United States)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^f IL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CORN OIL; LINOLEIC ACID; MARGARINE; SATURATED FATTY ACID; VEGETABLE OIL; FAT INTAKE;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; AUTOPSY; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; FAT INTAKE; FEMALE; HEART INFARCTION; HUMAN; HYPOTHESIS; ISCHEMIC HEART DISEASE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL HOSPITAL; META ANALYSIS (TOPIC); NURSING HOME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK BENEFIT ANALYSIS; RISK REDUCTION; SEX DIFFERENCE; SYSTEMATIC REVIEW (TOPIC); UNITED STATES; VERY ELDERLY; ADVERSE EFFECTS; BLOOD; CORONARY ARTERY DISEASE; CORONARY DISEASE; DIET THERAPY; DOUBLE BLIND PROCEDURE; HISTORY; KAPLAN MEIER METHOD; LOW FAT DIET; META ANALYSIS; MIDDLE AGED; MINNESOTA; MORTALITY; MYOCARDIAL INFARCTION; PROCEDURES; RISK FACTOR; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CAUSE OF DEATH; CHOLESTEROL; CORONARY ARTERY DISEASE; CORONARY DISEASE; DIET, FAT-RESTRICTED; DIETARY FATS; DOUBLE-BLIND METHOD; FEMALE; HISTORY, 20TH CENTURY; HUMANS; KAPLAN-MEIER ESTIMATE; LINOLEIC ACID; MALE; MIDDLE AGED; MINNESOTA; MYOCARDIAL INFARCTION; PLANT OILS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; YOUNG ADULT;

EID: 84964391250     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.i1246     Document Type: Article

References (79)

1. Sherwin R. Controlled trials of the diet-heart hypothesis: some comments on the experimental unit. Am J Epidemiol 1978;108:92-9.
2. Executive Committee on Diet and Heart Disease. National Diet-Heart Study Report. American Heart Association, 1968.
3. Getz GS, Vesselinovitch D, Wissler RW. A dynamic pathology of arteriosclerosis. Am J Med 1969;46:657-73. doi:10.1016/0002-9343 (69) 90018-7.
4. Camejo G, Waich S, Quintero G, Berrizbeitia ML, Lalaguna F. The affinity of low density lipoproteins for an arterial macromolecular complex. A study in ischemic heart disease and controls. Atherosclerosis 1976;24:341-54. doi:10.1016/0021-9150 (76) 90126-X.
5. Armstrong ML, Warner ED, Connor WE. Regression of coronary atheromatosis in rhesus monkeys. Circ Res 1970;27:59-67. doi:10.1161/01. RES.27.1.59.
6. Frantz ID Jr, Keys A. R01 HE 0986-03 Research Grant Application: Effect of a Dietary Change on Human Cardiovascular Disease "The Minnesota Coronary Survey". 1967. http://www.add.lib.iastate.edu/spcl/manuscripts/MS576.html
7. Broste S. Lifetable Analysis of the Minnesota Coronary Survey. University of Minnesota, 1981.
8. Mensink RP, Zock PL, Kester AD, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146-55.
9. Van Assche K, Capitaine L, Pennings G, Sterckx S. Governing the postmortem procurement of human body material for research. Kennedy Inst Ethics J 2015;25:67-88. doi:10.1353/ken. 2015.0000.
10. Keys A, Anderson JT, Grande F. Prediction of serum-cholesterol responses of man to changes in fats in the diet. Lancet 1957;273:959-66. doi:10.1016/S0140-6736 (57) 91998-0.
11. Keys A, Anderson JT, Grande F. Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet. Metabolism 1965;14:776-87. doi:10.1016/0026-0495 (65) 90004-1.
12. Keys A, Anderson JT, Grande F. Serum cholesterol response to changes in the diet: I. Iodine value of dietary fat versus 2S-P. Metabolism 1965;14:747-58. doi:10.1016/0026-0495 (65) 90001-6.
13. Caplan AL. Morality dissected: a plea for reform of current policies with respect to autopsy. Hum Pathol 1984;15:1105-6. doi:10.1016/S0046-8177 (84) 80304-4.
14. Ramsden CE, Zamora D, Leelarthaepin B, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ 2013;346:e8707. doi:10.1136/bmj.e8707.
15. Frantz ID Jr, Dawson EA, Ashman PL, et al. Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey. Arteriosclerosis 1989;9:129-35. doi:10.1161/01. ATV.9.1.129.
16. Brewer ER, Ashman PL, Kuba K. The Minnesota Coronary Survey: composition of their diets, adherence, and serum lipid response. Circulation 1975;51(suppl 2):1-269.
17. Dawson E, Gatewood L. The Minnesota coronary survey: methodology and characteristics of the population. Circulation 1975;52(suppl 2):271.
18. Frantz ID, Dawson EA, Kuba K, Brewer ER, Gatewood LC, Bartsch GE. The Minnesota Coronary Survey: Effect of diet on cardiovascular events and deaths. American Heart Association Scientific Proceedings. 1975 October 51 & 52(Supplement II): II-4.
19. Frantz ID. (PI) R01 HE 0986-02 Supplementary Progress Report: Effect of a Dietary Change on Human Cardiovascular Disease "The Minnesota Coronary Survey", August 31, 1967. http://www.add.lib. iastate.edu/spcl/manuscripts/MS576.html
20. Frantz ID, Jr. R01 HE 0986-02 Second Supplementary Progress Report: Effect of a Dietary Change on Human Cardiovascular Disease "The Minnesota Coronary Survey", September 25, 1967. http://www.add.lib.iastate.edu/spcl/manuscripts/MS576.html
21. Spiekerman RE, Brandenburg JT, Achor RW, Edwards JE. The spectrum of coronary heart disease in a community of 30, 000. A clinicopathologic study. Circulation 1962;25:57-65. doi:10.1161/01. CIR.25.1.57.
22. Frantz I. Chemical Analysis of Three Week Food Collection in the Control and Treatment Diets for the Minnesota Coronary Survey: Unpublished Data Comparing the Institutional BC Diets at the Seven Individual Hospitals of the MCS. 1971. http://www.add.lib.iastate.edu/spcl/manuscripts/MS576.html
23. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6:e1000097. doi:10.1371/journal. pmed.1000097.
24. Enig MG, Atal S, Keeney M, Sampugna J. Isomeric trans fatty acids in the U. S. diet[eng.]. J Am Coll Nutr 1990;9:471-86. doi:10.1080/07315724.1990.10720404.
25. Sastry PS. Lipids of nervous tissue: composition and metabolism. Prog Lipid Res 1985;24:69-176. doi:10.1016/0163-7827 (85) 90011-6.
26. DHEW Publication (NIH) 75-628: Manual of Laboratory Operations-Lipid Research Clinic Program, Volume 1-Lipid and Lipoprotein Analysis, May 1974.
27. Keys A, Grande F, Anderson JT. Bias and misrepresentation revisited: "perspective" on saturated fat. Am J Clin Nutr 1974;27:188-212.
28. Bandeen-Roche K, Xue QL, Ferrucci L, et al. Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci 2006;61:262-6. doi:10.1093/gerona/61.3.262.
29. Fried LP, Tangen CM, Walston J, et al. Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:M146-56. doi:10.1093/gerona/56.3. M146.
30. Rockwood MR, Howlett SE. Blood pressure in relation to age and frailty. Can Geriatr J 2011;14:2-7. doi:10.5770/cgj.v14i1.1.
31. Maki KC, Slavin JL, Rains TM, Kris-Etherton PM. Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr 2014;5:7-15. doi:10.3945/an. 113.004929.
32. Young SS, Karr A. Deming, data and observational studies: A process out of control and needing fixing. Significance 2011;8:116-20 doi:10.1111/j.1740-9713.2011.00506.x.
33. Kristal AR, Peters U, Potter JD. Is it time to abandon the food frequency questionnaire? Cancer Epidemiol Biomarkers Prev 2005;14:2826-8. doi:10.1158/1055-9965. EPI-12-ED1.
34. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 1991;20:47-63. doi:10.1016/0091-7435 (91) 90006-P.
35. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: scientific review. JAMA 2002;288:872-81. doi:10.1001/jama.288.7.872.
36. Grodstein F. Invited commentary: can selection bias explain the cardiovascular benefits of estrogen replacement therapy? Am J Epidemiol 1996;143:979-82, discussion 983-4. doi:10.1093/oxfordjournals.aje.a008679.
37. Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC. Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study[eng.]. Am J Epidemiol 2005;161:672-9. doi:10.1093/aje/kwi085.
38. Vangaveti V, Baune BT, Kennedy RL. Hydroxyoctadecadienoic acids: novel regulators of macrophage differentiation and atherogenesis. Ther Adv Endocrinol Metab 2010;1:51-60. doi:10.1177/2042018810375656.
39. Farvid MS, Ding M, Pan A, et al. Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. Circulation 2014;130:1568-78. doi:10.1161/CIRCULATIONAHA.114.010236.
40. Ramsden CE, Ringel A, Majchrzak-Hong SF, et al. Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? Mol Pain (in press).
41. Chowdhury R, Warnakula S, Kunutsor S, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med 2014;160:398-406. doi:10.7326/M13-1788.
42. de Oliveira Otto MC, Wu JH, Baylin A, et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 2013;2:e000506. doi:10.1161/JAHA.113.000506.
43. Wu JH, Lemaitre RN, King IB, et al. Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study. Circulation 2014;130:1245-53. doi:10.1161/CIRCULATIONAHA.114.011590.
44. Willett WC. The role of dietary n-6 fatty acids in the prevention of cardiovascular disease. J Cardiovasc Med (Hagerstown) 2007;8(Suppl 1):S42-5. doi:10.2459/01. JCM.0000289275.72556.13.
45. Lowering Blood Cholesterol To Prevent Heart Disease. NIH Consensus Statement Online 1984 Dec. 10-12;5(7):1-11.
46. Ramsden CE, Zamora D, Leelarthaepin B, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ 2013;346:e8707. http://www.bmj.com/content/346/bmj.e8707/rr/631590doi:10.1136/bmj.e8707.
47. Ramasamy I. Recent advances in physiological lipoprotein metabolism. Clin Chem Lab Med 2014;52:1695-727. doi:10.1515/cclm-2013-0358.
48. He J, Lee JH, Febbraio M, Xie W. The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease. Exp Biol Med (Maywood) 2011;236:1116-21. doi:10.1258/ebm.2011.011128.
49. Diffenderfer MR, Schaefer EJ. The composition and metabolism of large and small LDL. Curr Opin Lipidol 2014;25:221-6. doi:10.1097/MOL.0000000000000067.
50. Spady DK. Hepatic clearance of plasma low density lipoproteins. Semin Liver Dis 1992;12:373-85. doi:10.1055/s-2008-1040407.
51. Naci H, Brugts JJ, Fleurence R, Tsoi B, Toor H, Ades AE. Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials. Eur J Prev Cardiol 2013;20:641-57. doi:10.1177/2047487313480435.
52. Buchwald H, Varco RL, Matts JP, et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). N Engl J Med 1990;323:946-55. doi:10.1056/NEJM199010043231404.
53. The Coronary Drug Project. The Coronary Drug Project. Findings leading to discontinuation of the 2.5-mg day estrogen group. The coronary Drug Project Research Group. JAMA 1973;226:652-7. doi:10.1001/jama.1973.03230060030009.
54. The Coronary Drug Project. The Coronary Drug Project. Initial findings leading to modifications of its research protocol. JAMA 1970;214:1303-13. doi:10.1001/jama.1970.03180070069012.
55. The coronary drug project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. The coronary drug project research group. JAMA 1972;220:996-1008. doi:10.1001/jama.1972.03200070084015.
56. Kuipers RS, Luxwolda MF, Dijck-Brouwer DA, et al. Estimated macronutrient and fatty acid intakes from an East African Paleolithic diet[eng.]. Br J Nutr 2010;104:1666-87. doi:10.1017/S0007114510002679.
57. Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr 2011;93:950-62. doi:10.3945/ajcn. 110.006643.
58. US Department of Agriculture, Agricultural Research Service. Nutrient Intakes from Food: Mean Amounts Consumed per Individual, by Gender and Age, What We Eat in America, National Health and Nutrition Examination Survey (NHANES 2011-2012).
59. Guesnet P, Lallemand SM, Alessandri JM, Jouin M, Cunnane SC. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. Prostaglandins Leukot Essent Fatty Acids 2011;85:353-60. doi:10.1016/j.plefa.2011.08.003.
60. Blanchard H, Pedrono F, Boulier-Monthean N, Catheline D, Rioux V, Legrand P. Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. Prostaglandins Leukot Essent Fatty Acids 2013;88:383-9. doi:10.1016/j.plefa.2013.03.006.
61. US Department of Agriculture, Agricultural Research Service. 2010. USDA National Nutrient Database for Standard Reference, Release 23. Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/nutrientdata.
62. Ramsden CE, Ringel A, Feldstein AE, et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukot Essent Fatty Acids 2012;87:135-41. doi:10.1016/j.plefa.2012.08.004.
63. Marmesat S, Morales A, Velasco J, Carmen Dobarganes M. Influence of fatty acid composition on chemical changes in blends of sunflower oils during thermoxidation and frying. Food Chem 2012;135:2333-9. doi:10.1016/j.foodchem.2012.06.128.
64. Thompson LU, Aust R. Lipid Changes in French Fries and Heated Oils During Commercial Deep Frying and Their Nutritional and Toxicological Implications. Can Inst Food Sci Technol 1983;16:246-53 doi:10.1016/S0315-5463 (83) 72257-1.
65. Wilson R, Lyall K, Smyth L, Fernie CE, Riemersma RA. Dietary hydroxy fatty acids are absorbed in humans: implications for the measurement of 'oxidative stress' in vivo. Free Radic Biol Med 2002;32:162-8. doi:10.1016/S0891-5849 (01) 00780-8.
66. Ferreiro-Vera C, Priego-Capote F, Mata-Granados JM, Luque de Castro MD. Short-term comparative study of the influence of fried edible oils intake on the metabolism of essential fatty acids in obese individuals. Food Chem 2013;136:576-84. doi:10.1016/j.foodchem.2012.08.081.
67. Patwardhan AM, Akopian AN, Ruparel NB, et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest 2010;120:1617-26. doi:10.1172/JCI41678.
68. Patwardhan AM, Scotland PE, Akopian AN, Hargreaves KM. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A 2009;106:18820-4. doi:10.1073/pnas.0905415106.
69. Ramsden CE, Faurot KR, Zamora D, et al. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain 2013;154:2441-51. doi:10.1016/j.pain. 2013.07.028.
70. Feldstein AE, Lopez R, Tamimi TA, et al. Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Lipid Res 2010;51:3046-54. doi:10.1194/jlr. M007096.
71. Kirpich IA, Feng W, Wang Y, et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. Alcohol 2013;47:257-64. doi:10.1016/j.alcohol.2013.01.005.
72. Liu H, Beier JI, Arteel GE, et al. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. Am J Pathol 2015;185:43-54. doi:10.1016/j.ajpath.2014.09.007.
73. Godlee F, Loder E. Missing clinical trial data: setting the record straight. BMJ 2010;341:c5641. doi:10.1136/bmj.c5641.
74. Lehman R, Loder E. Missing clinical trial data. BMJ 2012;344:d8158. doi:10.1136/bmj.d8158.
75. WHO Statement on Public Disclosure of Clinical Trial Results. WHO, 2015.
76. Dietary goals for the United States, 2d ed. prepared by the staff of the Select Committee on Nutrition and Human Needs, United States Senate. US Govt. Print. Office in Washington DC, 1977. https://openlibrary.org/books/OL4373027M/Dietary-goals-for-the-United-States.
77. Anderson JT, Grande F, Keys A. Hydrogenated fats in the diet and lipids in the serum of man. J Nutr 1961;75:388-94. pmid:13861251.
78. Ramsden CE, Zamora D, Makriyannis A, et al. Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress. J Pain 2015;16:707-16. doi:10.1016/j. jpain. 2015.04.007.
79. Chemin J, Cazade M, Lory P. Modulation of T-type calcium channels by bioactive lipids. Pflugers Arch 2014;466:689-700. doi:10.1007/s00424-014-1467-5.