Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 2, 2014, Pages 392-404

  Parker, Lorien J ^a   Taruya, Shigenao ^a   Tsuganezawa, Keiko ^a   Ogawa, Naoko ^a   Mikuni, Junko ^a   Honda, Keiko ^a   Tomabechi, Yuri ^a   Handa, Noriko ^a   Shirouzu, Mikako ^a   Yokoyama, Shigeyuki ^a   Tanaka, Akiko ^a  

^a RIKEN   (Japan)

Author keywords

co crystallization; fluorescence; inhibitor screening; kinase; SKF86002

Indexed keywords

6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDINYL)IMIDAZO(2,1 B)THIAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO(2,1-B)THIAZOLE; ADENOSINE TRIPHOSPHATE; APOPTOSIS SIGNAL REGULATING KINASE 1; FLUORESCENT DYE; HCK PROTEIN, HUMAN; HEMATOPOIETIC CELL KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMIDAZOLE DERIVATIVE; LIGAND; MAP3K5 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 14; PHOSPHOTRANSFERASE; PIM1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1; RECOMBINANT PROTEIN; THIAZOLE DERIVATIVE;

ARTICLE; BINDING COMPETITION; CHEMISTRY; CO-CRYSTALLIZATION; CRYSTALLIZATION; DRUG ANTAGONISM; ESCHERICHIA COLI; FLUORESCENCE; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; INHIBITOR SCREENING; METABOLISM; MOLECULAR PROBE; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

CO-CRYSTALLIZATION; FLUORESCENCE; INHIBITOR SCREENING; KINASE; SKF86002;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; BINDING, COMPETITIVE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMIDAZOLES; LIGANDS; MAP KINASE KINASE KINASE 5; MITOGEN-ACTIVATED PROTEIN KINASE 14; MOLECULAR PROBES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-HCK; PROTO-ONCOGENE PROTEINS C-PIM-1; RECOMBINANT PROTEINS; THIAZOLES;

EID: 85047688883     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004713028654     Document Type: Article

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