A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide

Journal of Molecular Biology

Volumn 417, Issue 3, 2012, Pages 240-252

  Tsuganezawa, Keiko ^a   Watanabe, Hisami ^a   Parker, Lorien ^a   Yuki, Hitomi ^a   Taruya, Shigenao ^a   Nakagawa, Yukari ^a   Kamei, Daisuke ^a   Mori, Masumi ^a   Ogawa, Naoko ^a   Tomabechi, Yuri ^a   Handa, Noriko ^a   Honma, Teruki ^a   Yokoyama, Shigeyuki ^a,b   Kojima, Hirotatsu ^b   Okabe, Takayoshi ^b   Nagano, Tetsuo ^b   Tanaka, Akiko ^a,b  

^a RIKEN   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

fluorescent correlation spectroscopy; inhibitor; leukemia cell lethality; Pim 1; substrate peptide binding residue

Indexed keywords

PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 1 INHIBITOR; PROTEIN P21; PROTEIN P27; QUERCETIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG SCREENING; FLUORESCENCE CORRELATION SPECTROSCOPY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; X RAY CRYSTALLOGRAPHY;

EID: 84857654419     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.01.036     Document Type: Article

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