Flexibility of the P-loop of Pim-1 kinase: Observation of a novel conformation induced by interaction with an inhibitor

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 68, Issue 8, 2012, Pages 860-866

  Parker, Lorien J ^a   Watanabe, Hisami ^a   Tsuganezawa, Keiko ^a   Tomabechi, Yuri ^a   Handa, Noriko ^a   Shirouzu, Mikako ^a   Yuki, Hitomi ^a   Honma, Teruki ^a   Ogawa, Naoko ^a   Nagano, Tetsuo ^b   Yokoyama, Shigeyuki ^a,b   Tanaka, Akiko ^a,b  

^a RIKEN   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

inhibitors; kinases; Pim 1

Indexed keywords

PROTEIN KINASE INHIBITOR; PROTEIN KINASE PIM 1;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; HYDROGEN BOND; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, QUATERNARY; PROTO-ONCOGENE PROTEINS C-PIM-1; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84864872683     PISSN: None     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309112027108     Document Type: Article

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