Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase

Journal of Medicinal Chemistry

Volumn 49, Issue 20, 2006, Pages 5939-5946

  Bosch, Jürgen ^a,b,c   Robien, Mark A ^a,c   Mehlin, Christopher ^a,c   Boni, Erica ^a,c   Riechers, Aaron ^b   Buckner, Frederick S ^b,c   Van Voorhis, Wesley C ^b,c   Myler, Peter J ^d   Worthey, Elizabeth A ^d   DeTitta, George ^e   Luft, Joseph R ^e   Lauricella, Angela ^e   Gulde, Stacey ^e   Anderson, Lori A ^a,c   Kalyuzhniy, Oleksandr ^a,c   Neely, Helen M ^a,c   Ross, Jenni ^a,c   Earnest, Thomas N ^f   Soltis, Michael ^g   Schoenfeld, Lori ^a,c   Zucker, Frank ^a,c   Merritt, Ethan A ^a,c   Fan, Erkang ^a,c   Verlinde, Christophe L M J ^a,c   Hol, Wim G J ^a,b,c   more..

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Structural Genomics of Pathogenic Protozoa (SGPP) Consortium   (United States)

^d SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^e HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^f LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^g SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYLQUINOLINE 2(1H) ONE; 2 ETHYLBENZYL ALCOHOL; 5 AMINOISOQUINOLINE; BENZO[CD]INDOL 2(1H) ONE; COMPLEMENTARY DNA; ENZYME INHIBITOR; GLYCOSYLTRANSFERASE; LIGAND; NUCLEOSIDE 2 DEOXYRIBOSYLTRANSFERASE; PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; GROWTH INHIBITION; HYDROPHOBICITY; IN VITRO STUDY; LACTOBACILLUS HELVETICUS; LIGHT SCATTERING; NONHUMAN; TRYPANOSOMA BRUCEI; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BENZYL ALCOHOLS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; INDOLES; ISOQUINOLINES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PENTOSYLTRANSFERASES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 33749262286     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060429m     Document Type: Article

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