Structures of p38α Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation

Journal of Molecular Biology

Volumn 365, Issue 1, 2007, Pages 66-76

  Diskin, Ron ^a   Lebendiker, Mario ^a   Engelberg, David ^a   Livnah, Oded ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

active mutants; crystal structure; dimerization; mitogen activated protein kinase; p38

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; AUTOPHOSPHORYLATION; AUTOREGULATION; CHEMICAL ANALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; MUTANT; PRIORITY JOURNAL; PROTEIN STRUCTURE; T LYMPHOCYTE; AMINO ACID SEQUENCE; CHEMISTRY; DIMERIZATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY;

EID: 33751392926     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.08.043     Document Type: Article

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