Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium

Current Topics in Medicinal Chemistry

Volumn 9, Issue 18, 2009, Pages 1678-1687

  Verlinde, Christophe L M J ^a,b   Fan, Erkang ^a,b   Shibata, Sayaka ^a,b   Zhang, Zhongsheng ^a,b   Sun, Zhihua ^a,b   Deng, Wei ^a,b   Ross, Jennifer ^a,b   Kim, Jessica ^a,b   Xiao, Liren ^a,b   Arakaki, Tracy L ^a,b   Bosch, Jürgen ^a,b   Caruthers, Jonathan M ^a,b   Larson, Eric T ^a,b   LeTrong, Isolde ^a,b   Napuli, Alberto ^a,b   Kelley, Angela ^a,c   Mueller, Natasha ^a,c   Zucker, Frank ^a,b   Van Voorhis, Wesley C ^a,c   Buckner, Frederick S ^a,c   Merritt, Ethan A ^a,b   Hol, Wim G J ^a,b   more..

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Biomolecular Structure Center   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Drug design; History; Leishmaniasis; Malaria; Structural genomics; Trypanosomiasis

Indexed keywords

1 METHYLQUINOLIN 2(1H) ONE; 2 ETHYLBENZYL ALCOHOL; 3 AMINOPYRROLIDINE; 5 AMINOISOQUINOLINE; 5 CHLORO 2 METHOXYBENZOIC ACID; 5 FLUOROINDOLE 2 CARBOXYLIC ACID; ADENYLATE KINASE; BENZO[CD]INDOL 2(1H) ONE; COPROPORPHYRINOGEN OXIDASE; CYCLOPENTYLACETIC ACID; ENZYME INHIBITOR; EPIMERASE; LIGAND; PHOSPHOGLYCERATE MUTASE; PROTOZOAL PROTEIN; TRANSFERASE; UNCLASSIFIED DRUG; URACIL DNA GLYCOSIDASE; MOLECULAR LIBRARY;

ARTICLE; CRYSTAL; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; FRAGMENT BASED DRUG DISCOVERY METHOD; NONHUMAN; PROTOZOON; STRUCTURAL GENOMICS; STRUCTURE ANALYSIS; CHEMISTRY; DRUG DEVELOPMENT; GENOME; HUMAN; MOLECULAR LIBRARY; PHARMACOLOGY; PROCEDURES; PROTOZOAN INFECTIONS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG DISCOVERY; GENOME, PROTOZOAN; HUMANS; PROTOZOAN INFECTIONS; SMALL MOLECULE LIBRARIES;

EID: 74249098563     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802609790102383     Document Type: Article

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