Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain

Acta Crystallographica Section D: Biological Crystallography

Volumn 67, Issue 5, 2011, Pages 480-487

  Handa, Noriko ^a   Takagi, Tetsuo ^a   Saijo, Shinya ^a   Kishishita, Seiichiro ^a   Takaya, Daisuke ^a   Toyama, Mitsutoshi ^a   Terada, Takaho ^a   Shirouzu, Mikako ^a   Suzuki, Atsushi ^b   Lee, Suni ^b   Yamauchi, Toshimasa ^c   Okada Iwabu, Miki ^c   Iwabu, Masato ^c   Kadowaki, Takashi ^c   Minokoshi, Yasuhiko ^b   Yokoyama, Shigeyuki ^a,d  

^a RIKEN   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

AMP activated protein kinase; compound C; drug design; metabolic syndrome; Ser Thr protein kinases

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; HUMAN; METABOLIC SYNDROME X; MOLECULAR GENETICS; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS, TYPE 2; HUMANS; METABOLIC SYNDROME X; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OBESITY; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT;

EID: 79955656064     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444911010201     Document Type: Article

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