Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Sarkar, Anita ^a   Bale, Shridhar ^a   Behrens, Anna Janina ^b   Kumar, Sonu ^a   Sharma, Shailendra Kumar ^a   De Val, Natalia ^a   Pallesen, Jesper ^a   Irimia, Adriana ^a   Diwanji, Devan C ^a   Stanfield, Robyn L ^a   Ward, Andrew B ^a   Crispin, Max ^a,b,c   Wyatt, Richard T ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; FURIN; GLYCOPROTEIN; GLYCOPROTEIN BG505 NFL.664; KIFUNENSINE; NEUTRALIZING ANTIBODY; PGT122 ANTIGEN; PGV19 ANTIGEN; SWAINSONINE; UNCLASSIFIED DRUG; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; PROTEIN BINDING; VIRUS ENVELOPE PROTEIN;

CARBOHYDRATE; CELL; CHEMICAL BINDING; CRYSTAL STRUCTURE; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; MATURATION; PEPTIDE; PROTEIN;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; GLYCOSYLATION; HEK293-FT CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RECEPTOR BINDING; VIRUS ENTRY; VIRUS ENVELOPE; CHEMISTRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, NEUTRALIZING; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES; GLYCOPROTEINS; GLYCOSYLATION; HIV ANTIBODIES; HIV-1; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 85047071167     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04272-y     Document Type: Article

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