A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans

Immunity

Volumn 45, Issue 1, 2016, Pages 31-45

  Sok, Devin ^a,b   Pauthner, Matthias ^a   Briney, Bryan ^a   Lee, Jeong Hyun ^a   Saye Francisco, Karen L ^a   Hsueh, Jessica ^a   Ramos, Alejandra ^a,b   Le, Khoa M ^a   Jones, Meaghan ^a   Jardine, Joseph G ^a   Bastidas, Raiza ^a   Sarkar, Anita ^a   Liang, Chi Hui ^a   Shivatare, Sachin S ^c   Wu, Chung Yi ^c   Schief, William R ^a,d   Wong, Chi Huey ^c   Wilson, Ian A ^a   Ward, Andrew B ^a   Zhu, Jiang ^a   Poignard, Pascal ^a,b   Burton, Dennis R ^a,d   more..

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^c GENOMICS RESEARCH CENTER   (Taiwan)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; EPITOPE; GLYCAN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 160; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS GLYCOPROTEIN; CCR5 PROTEIN, HUMAN; CD4 ANTIGEN; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PEPTIDE FRAGMENT; POLYSACCHARIDE; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; BIOLOGICAL MIMICRY; CONTROLLED STUDY; EMBRYO; EPITOPE MAPPING; GENE MUTATION; GENETIC VARIABILITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MEMORY CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN MOTIF; RECEPTOR BINDING; VIRUS CELL INTERACTION; VIRUS ENVELOPE; VIRUS NEUTRALIZATION; ANTIBODY COMBINING SITE; GENETIC ENGINEERING; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM;

AMINO ACID MOTIFS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; BINDING SITES, ANTIBODY; EPITOPE MAPPING; EPITOPES; GENETIC ENGINEERING; HEK293 CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, HUMORAL; IMMUNOLOGIC MEMORY; PEPTIDE FRAGMENTS; POLYSACCHARIDES; PROTEIN BINDING; RECEPTORS, CCR5;

EID: 84990856306     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.06.026     Document Type: Article

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