hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells

Cancer Biology and Therapy

Volumn 8, Issue 7, 2009, Pages

  Gao, Fangming ^a   Ponte, Jose F ^a,b   Papageorgis, Panagiotis ^a   Levy, Mary ^a   Ozturk, Sait ^a   Lambert, Arthur W ^a   Pan, Hongjie ^a   Chinnappan, Dharmaraj ^a   Cheng, Kuang Hung ^a,c   Thiagalingam, Arunthathi ^a,d   Abdolmaleky, Hamid M ^a   Thiagalingam, Sam ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TolerRx Inc   (United States)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d Biomeasure Inc   (United States)

Author keywords

Aneuploidy; Apoptosis; Cancer; Genomic instability; hBub1; hMad2; p53; PUMA; shRNA; Spindle assembly checkpoint

Indexed keywords

BUB1 RELATED PROTEIN; LENTIVIRUS VECTOR; LUCIFERASE; NOCODAZOLE; PACLITAXEL; PROTEIN MAD2; PROTEIN P53; PUMA PROTEIN; SHORT HAIRPIN RNA; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN, HUMAN; BBC3 PROTEIN, HUMAN; BUB1 SPINDLE CHECKPOINT PROTEIN; CALCIUM BINDING PROTEIN; CELL CYCLE PROTEIN; MAD2L1 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN BAX; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; SMALL INTERFERING RNA; TP53 PROTEIN, HUMAN;

ANEUPLOIDY; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN HCT116; CENTROMERE; COLORECTAL CANCER; CONTROLLED STUDY; CYTOGENETICS; DNA CONTENT; ENZYME ASSAY; FLUORESCENCE ACTIVATED CELL SORTER; FLUORESCENCE MICROSCOPY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MITOSIS; MITOSIS SPINDLE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEFICIENCY; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; BIOSYNTHESIS; CELL GROWTH; GENETICS; METABOLISM; PHYSIOLOGY; UPREGULATION;

ANEUPLOIDY; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM-BINDING PROTEINS; CELL CYCLE PROTEINS; CELL GROWTH PROCESSES; HCT116 CELLS; HUMANS; MITOTIC SPINDLE APPARATUS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 85046915229     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.7.7928     Document Type: Article

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