Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis

Cancer Research

Volumn 69, Issue 1, 2009, Pages 45-54

  Schliekelman, Mark ^a,b   Cowley, Dale O ^b,c   O'Quinn, Ryan ^a   Oliver, Trudy G ^b,d   Lu, Cy ^b   Salmon, E D ^a   Van Dyke, Terry ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c GLAXOSMITHKLINE   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; BUB1 RELATED PROTEIN 1; NOCODAZOLE; PACLITAXEL; PROTEIN MAD2; PROTEIN P53; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CENTROMERE; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; EMBRYO; EMBRYO DEVELOPMENT; FIBROBLAST; HOMOZYGOSITY; IN VIVO STUDY; LETHAL MUTANT; METAPHASE; MITOSIS SPINDLE; MOUSE; NONHUMAN; NULL ALLELE; PERINATAL DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SENESCENCE; SPINDLE ASSEMBLY CHECKPOINT MECHANISM; YEAST;

ALLELES; ANEUPLOIDY; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME SEGREGATION; FEMALE; FIBROBLASTS; KINETOCHORES; MALE; MICE; MICE, INBRED C57BL; MITOTIC SPINDLE APPARATUS; MUTATION; NOCODAZOLE; PACLITAXEL; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER;

EID: 58249094849     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6330     Document Type: Article

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