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Volumn 46, Issue 1, 2018, Pages 11-21

MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; COBOMARSEN; MICRORNA; MICRORNA 29; MIRAVIRSEN; OLIGONUCLEOTIDE; SMALL INTERFERING RNA; TEMAVIRSEN; VIRUS VECTOR; MESSENGER RNA;

EID: 85046845971     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20170037     Document Type: Review
Times cited : (123)

References (82)
  • 1
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller, M. (2011) Non-coding RNAs in human disease. Nat. Rev. Genet. 12, 861–874 https://doi.org/10.1038/nrg3074
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 861-874
    • Esteller, M.1
  • 3
    • 60149091189 scopus 로고    scopus 로고
    • Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
    • Sonenberg, N. and Hinnebusch, A.G. (2009) Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731–745 https://doi.org/10.1016/j.cell.2009.01.042
    • (2009) Cell , vol.136 , pp. 731-745
    • Sonenberg, N.1    Hinnebusch, A.G.2
  • 4
    • 84897128298 scopus 로고    scopus 로고
    • The noncoding RNA revolution—trashing old rules to forge new ones
    • Cech, T.R. and Steitz, J.A. (2014) The noncoding RNA revolution—trashing old rules to forge new ones. Cell 157, 77–94 https://doi.org/10.1016/j.cell.2014.03.008
    • (2014) Cell , vol.157 , pp. 77-94
    • Cech, T.R.1    Steitz, J.A.2
  • 5
    • 84879987789 scopus 로고    scopus 로고
    • LincRNAs: Genomics, evolution, and mechanisms
    • Ulitsky, I. and Bartel, D.P. (2013) lincRNAs: genomics, evolution, and mechanisms. Cell 154, 26–46 https://doi.org/10.1016/j.cell.2013.06.020
    • (2013) Cell , vol.154 , pp. 26-46
    • Ulitsky, I.1    Bartel, D.P.2
  • 6
    • 84949952099 scopus 로고    scopus 로고
    • Unique features of long non-coding RNA biogenesis and function
    • Quinn, J.J. and Chang, H.Y. (2016) Unique features of long non-coding RNA biogenesis and function. Nat. Rev. Genet. 17, 47–62 https://doi.org/10.1038/nrg.2015.10
    • (2016) Nat. Rev. Genet. , vol.17 , pp. 47-62
    • Quinn, J.J.1    Chang, H.Y.2
  • 7
    • 0027751663 scopus 로고
    • The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R.C., Feinbaum, R.L. and Ambros, V. (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843–854 https://doi.org/10.1016/0092-8674(93)90529-Y
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 8
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D.P. (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281–297 https://doi.org/10.1016/S0092-8674(04)00045-5
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 9
    • 58449134534 scopus 로고    scopus 로고
    • Small silencing RNAs: An expanding universe
    • Ghildiyal, M. and Zamore, P.D. (2009) Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 10, 94–108 https://doi.org/10.1038/nrg2504
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 94-108
    • Ghildiyal, M.1    Zamore, P.D.2
  • 10
    • 84931572130 scopus 로고    scopus 로고
    • Towards a molecular understanding of microRNA-mediated gene silencing
    • Jonas, S. and Izaurralde, E. (2015) Towards a molecular understanding of microRNA-mediated gene silencing. Nat. Rev. Genet. 16, 421–433 https://doi.org/10.1038/nrg3965
    • (2015) Nat. Rev. Genet. , vol.16 , pp. 421-433
    • Jonas, S.1    Izaurralde, E.2
  • 11
    • 84940502214 scopus 로고    scopus 로고
    • Predicting effective microRNA target sites in mammalian mRNAs
    • Agarwal, V., Bell, G.W., Nam, J.-W. and Bartel, D.P. (2015) Predicting effective microRNA target sites in mammalian mRNAs. eLife 4, e05005 https://doi.org/10.7554/eLife.05005
    • (2015) eLife , vol.4 , pp. e05005
    • Agarwal, V.1    Bell, G.W.2    Nam, J.-W.3    Bartel, D.P.4
  • 12
    • 78751477191 scopus 로고    scopus 로고
    • Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
    • Huntzinger, E. and Izaurralde, E. (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat. Rev. Genet. 12, 99–110 https://doi.org/10.1038/nrg2936
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 99-110
    • Huntzinger, E.1    Izaurralde, E.2
  • 13
    • 84875992976 scopus 로고    scopus 로고
    • Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation
    • Hausser, J., Syed, A.P., Bilen, B. and Zavolan, M. (2013) Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation. Genome Res. 23, 604–615 https://doi.org/10.1101/gr.139758.112
    • (2013) Genome Res , vol.23 , pp. 604-615
    • Hausser, J.1    Syed, A.P.2    Bilen, B.3    Zavolan, M.4
  • 14
    • 84906313950 scopus 로고    scopus 로고
    • Identification and consequences of miRNA–target interactions—beyond repression of gene expression
    • Hausser, J. and Zavolan, M. (2014) Identification and consequences of miRNA–target interactions—beyond repression of gene expression. Nat. Rev. Genet. 15, 599–612 https://doi.org/10.1038/nrg3765
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 599-612
    • Hausser, J.1    Zavolan, M.2
  • 16
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review
    • Iorio, M.V. and Croce, C.M. (2012) MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol. Med. 4, 143–159 https://doi.org/10.1002/emmm.201100209
    • (2012) EMBO Mol. Med. , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 17
    • 85002795216 scopus 로고    scopus 로고
    • MicroRNAs in cardiovascular disease
    • Barwari, T., Joshi, A. and Mayr, M. (2016) MicroRNAs in cardiovascular disease. J. Am. Coll. Cardiol. 68, 2577–2584 https://doi.org/10.1016/j.jacc.2016.09.945
    • (2016) J. Am. Coll. Cardiol. , vol.68 , pp. 2577-2584
    • Barwari, T.1    Joshi, A.2    Mayr, M.3
  • 18
    • 34548537836 scopus 로고    scopus 로고
    • Molecular biology: miRNAs in neurodegeneration
    • Hebert, S.S. and De Strooper, B. (2007) Molecular biology: miRNAs in neurodegeneration. Science 317, 1179–1180 https://doi.org/10.1126/science. 1148530
    • (2007) Science , vol.317 , pp. 1179-1180
    • Hebert, S.S.1    De Strooper, B.2
  • 19
    • 84905503012 scopus 로고    scopus 로고
    • Therapeutic targeting of microRNAs: Current status and future challenges
    • Li, Z. and Rana, T.M. (2014) Therapeutic targeting of microRNAs: current status and future challenges. Nat. Rev. Drug Discov. 13, 622–638 https://doi.org/10.1038/nrd4359
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 622-638
    • Li, Z.1    Rana, T.M.2
  • 20
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, O. et al. (2008) LNA-mediated microRNA silencing in non-human primates. Nature 452, 896–899 https://doi.org/10.1038/nature06783
    • (2008) Nature , vol.452 , pp. 896-899
    • Elmén, J.1    Lindow, M.2    Schütz, S.3    Lawrence, M.4    Petri, A.5    Obad, O.6
  • 21
    • 79960365933 scopus 로고    scopus 로고
    • Functional genomics applied to cardiovascular medicine
    • Cappola, T.P. and Margulies, K.B. (2011) Functional genomics applied to cardiovascular medicine. Circulation 124, 87–94 https://doi.org/10.1161/CIRCULATIONAHA.111.027300
    • (2011) Circulation , vol.124 , pp. 87-94
    • Cappola, T.P.1    Margulies, K.B.2
  • 22
    • 84949495449 scopus 로고    scopus 로고
    • Microscopy-based high-content screening
    • Boutros, M., Heigwer, F. and Laufer, C. (2015) Microscopy-based high-content screening. Cell 163, 1314–1325 https://doi.org/10.1016/j.cell.2015.11. 007
    • (2015) Cell , vol.163 , pp. 1314-1325
    • Boutros, M.1    Heigwer, F.2    Laufer, C.3
  • 23
    • 85014432778 scopus 로고    scopus 로고
    • Knocking down the obstacles to functional genomics data sharing
    • Simpson, K.J. and Smith, J.A. (2017) Knocking down the obstacles to functional genomics data sharing. Sci. Data 4, 170019 https://doi.org/10.1038/sdata.2017.19
    • (2017) Sci. Data , vol.4 , pp. 170019
    • Simpson, K.J.1    Smith, J.A.2
  • 24
    • 85024490310 scopus 로고    scopus 로고
    • High-throughput imaging for the discovery of cellular mechanisms of disease
    • Pegoraro, G. and Misteli, T. (2017) High-throughput imaging for the discovery of cellular mechanisms of disease. Trends Genet. 33, 604–615 https://doi.org/10.1016/j.tig.2017.06.005
    • (2017) Trends Genet , vol.33 , pp. 604-615
    • Pegoraro, G.1    Misteli, T.2
  • 25
    • 84884514267 scopus 로고    scopus 로고
    • Developing microRNA screening as a functional genomics tool for disease research
    • Lemons, D., Maurya, M.R., Subramaniam, S. and Mercola, M. (2013) Developing microRNA screening as a functional genomics tool for disease research. Front. Physiol. 4, 223 https://doi.org/10.3389/fphys.2013.00223
    • (2013) Front. Physiol. , vol.4 , pp. 223
    • Lemons, D.1    Maurya, M.R.2    Subramaniam, S.3    Mercola, M.4
  • 26
    • 84960193171 scopus 로고    scopus 로고
    • Tiny giants of gene regulation: Experimental strategies for microRNA functional studies
    • Steinkraus, B.R., Toegel, M. and Fulga, T.A. (2016) Tiny giants of gene regulation: experimental strategies for microRNA functional studies. Wiley Interdiscip. Rev. Dev. Biol. 5, 311–362 https://doi.org/10.1002/wdev.223
    • (2016) Wiley Interdiscip. Rev. Dev. Biol. , vol.5 , pp. 311-362
    • Steinkraus, B.R.1    Toegel, M.2    Fulga, T.A.3
  • 27
    • 84866357155 scopus 로고    scopus 로고
    • MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways
    • Keklikoglou, I., Koerner, C., Schmidt, C., Zhang, J.D., Heckmann, D., Shavinskaya, A. et al. (2012) MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways. Oncogene 31, 4150–4163 https://doi.org/10.1038/onc.2011.571
    • (2012) Oncogene , vol.31 , pp. 4150-4163
    • Keklikoglou, I.1    Koerner, C.2    Schmidt, C.3    Zhang, J.D.4    Heckmann, D.5    Shavinskaya, A.6
  • 28
    • 84885423826 scopus 로고    scopus 로고
    • MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells
    • Judson, R.L., Greve, T.S., Parchem, R.J. and Blelloch, R. (2013) MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat. Struct. Mol. Biol. 20, 1227–1235 https://doi.org/10.1038/nsmb.2665
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 1227-1235
    • Judson, R.L.1    Greve, T.S.2    Parchem, R.J.3    Blelloch, R.4
  • 29
    • 84907343849 scopus 로고    scopus 로고
    • Functional high-throughput screening identifies the MIR-15 microRNA family as cellular restriction factors for Salmonella infection
    • Maudet, C., Mano, M., Sunkavalli, U., Sharan, M., Giacca, M., Förstner, K.U. et al. (2014) Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection. Nat. Commun. 5, 4718 https://doi.org/10.1038/ncomms5718
    • (2014) Nat. Commun. , vol.5 , pp. 4718
    • Maudet, C.1    Mano, M.2    Sunkavalli, U.3    Sharan, M.4    Giacca, M.5    Förstner, K.U.6
  • 30
    • 82555193281 scopus 로고    scopus 로고
    • Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis
    • Zhang, H., Hao, Y., Yang, J., Zhou, Y., Li, J., Yin, S. et al. (2011) Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. Nat. Commun. 2, 554 https://doi.org/10.1038/ncomms1555
    • (2011) Nat. Commun. , vol.2 , pp. 554
    • Zhang, H.1    Hao, Y.2    Yang, J.3    Zhou, Y.4    Li, J.5    Yin, S.6
  • 31
    • 38849107424 scopus 로고    scopus 로고
    • The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
    • Huang, Q., Gumireddy, K., Schrier, M., le Sage, C., Nagel, R., Nair, S. et al. (2008) The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat. Cell Biol. 10, 202–210 https://doi.org/10.1038/ncb1681
    • (2008) Nat. Cell Biol. , vol.10 , pp. 202-210
    • Huang, Q.1    Gumireddy, K.2    Schrier, M.3    Le Sage, C.4    Nagel, R.5    Nair, S.6
  • 32
    • 84155186597 scopus 로고    scopus 로고
    • A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes
    • Jentzsch, C., Leierseder, S., Loyer, X., Flohrschütz, I., Sassi, Y., Hartmann, D. et al. (2012) A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes. J. Mol. Cell. Cardiol. 52, 13–20 https://doi.org/10.1016/j.yjmcc.2011.07.010
    • (2012) J. Mol. Cell. Cardiol. , vol.52 , pp. 13-20
    • Jentzsch, C.1    Leierseder, S.2    Loyer, X.3    Flohrschütz, I.4    Sassi, Y.5    Hartmann, D.6
  • 33
    • 84871442001 scopus 로고    scopus 로고
    • Functional screening identifies miRNAs inducing cardiac regeneration
    • Eulalio, A., Mano, M., Ferro, M.D., Zentilin, L., Sinagra, G., Zacchigna, S. et al. (2012) Functional screening identifies miRNAs inducing cardiac regeneration. Nature 492, 376–381 https://doi.org/10.1038/nature11739
    • (2012) Nature , vol.492 , pp. 376-381
    • Eulalio, A.1    Mano, M.2    Ferro, M.D.3    Zentilin, L.4    Sinagra, G.5    Zacchigna, S.6
  • 34
    • 84899482237 scopus 로고    scopus 로고
    • Inhibition of miR-25 improves cardiac contractility in the failing heart
    • Wahlquist, C., Jeong, D., Rojas-Muñoz, A., Kho, C., Lee, A., Mitsuyama, S. et al. (2014) Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature 508, 531–535 https://doi.org/10.1038/nature13073
    • (2014) Nature , vol.508 , pp. 531-535
    • Wahlquist, C.1    Jeong, D.2    Rojas-Muñoz, A.3    Kho, C.4    Lee, A.5    Mitsuyama, S.6
  • 35
    • 40249106014 scopus 로고    scopus 로고
    • Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
    • Elmén, J., Lindow, M., Silahtaroglu, A., Bak, M., Christensen, M., Lind-Thomsen, A. et al. (2008) Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 36, 1153–1162 https://doi.org/10.1093/nar/gkm1113
    • (2008) Nucleic Acids Res , vol.36 , pp. 1153-1162
    • Elmén, J.1    Lindow, M.2    Silahtaroglu, A.3    Bak, M.4    Christensen, M.5    Lind-Thomsen, A.6
  • 36
    • 84907324806 scopus 로고    scopus 로고
    • Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization
    • Fiedler, J., Stöhr, A., Gupta, S.K., Hartmann, D., Holzmann, A., Just, A. et al. (2014) Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization. Antioxid. Redox Signal. 21, 1167–1176 https://doi.org/10.1089/ars.2013.5418
    • (2014) Antioxid. Redox Signal. , vol.21 , pp. 1167-1176
    • Fiedler, J.1    Stöhr, A.2    Gupta, S.K.3    Hartmann, D.4    Holzmann, A.5    Just, A.6
  • 37
    • 85013059434 scopus 로고    scopus 로고
    • MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases
    • Rupaimoole, R. and Slack, F.J. (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat. Rev. Drug Discov. 16, 203–222 https://doi.org/10.1038/nrd.2016.246
    • (2017) Nat. Rev. Drug Discov. , vol.16 , pp. 203-222
    • Rupaimoole, R.1    Slack, F.J.2
  • 38
    • 84979222074 scopus 로고    scopus 로고
    • Non-coding RNAs as drug targets
    • Matsui, M. and Corey, D.R. (2017) Non-coding RNAs as drug targets. Nat. Rev. Drug Discov. 16, 167–179 https://doi.org/10.1038/nrd.2016.117
    • (2017) Nat. Rev. Drug Discov. , vol.16 , pp. 167-179
    • Matsui, M.1    Corey, D.R.2
  • 40
    • 79959845414 scopus 로고    scopus 로고
    • MicroRNAs 103 and 107 regulate insulin sensitivity
    • Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M. et al. (2011) MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474, 649–653 https://doi.org/10.1038/nature10112
    • (2011) Nature , vol.474 , pp. 649-653
    • Trajkovski, M.1    Hausser, J.2    Soutschek, J.3    Bhat, B.4    Akin, A.5    Zavolan, M.6
  • 41
    • 85028676559 scopus 로고    scopus 로고
    • Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: A first-in-man, phase 1, open-label, dose-escalation study
    • van Zandwijk, N., Pavlakis, N., Kao, S.C., Linton, A., Boyer, M.J., Clarke, S. et al. (2017) Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. Lancet Oncol. 18, 1386–1396 https://doi.org/10.1016/S1470-2045(17)30621-6
    • (2017) Lancet Oncol , vol.18 , pp. 1386-1396
    • Van Zandwijk, N.1    Pavlakis, N.2    Kao, S.C.3    Linton, A.4    Boyer, M.J.5    Clarke, S.6
  • 42
    • 77952946050 scopus 로고    scopus 로고
    • MicroRNA-29, a key regulator of collagen expression in systemic sclerosis
    • Maurer, B., Stanczyk, J., Jüngel, A., Akhmetshina, A., Trenkmann, M., Brock, M. et al. (2010) MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum. 62, 1733–1743 https://doi.org/10.1002/art.27443
    • (2010) Arthritis Rheum , vol.62 , pp. 1733-1743
    • Maurer, B.1    Stanczyk, J.2    Jüngel, A.3    Akhmetshina, A.4    Trenkmann, M.5    Brock, M.6
  • 43
    • 84869219338 scopus 로고    scopus 로고
    • MiR-34 — A microRNA replacement therapy is headed to the clinic
    • Bader, A.G. (2012) miR-34 — a microRNA replacement therapy is headed to the clinic. Front. Genet. 3, 120 https://doi.org/10.3389/fgene.2012. 00120
    • (2012) Front. Genet. , vol.3 , pp. 120
    • Bader, A.G.1
  • 44
    • 84862993281 scopus 로고    scopus 로고
    • Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
    • Babar, I.A., Cheng, C.J., Booth, C.J., Liang, X., Weidhaas, J.B., Saltzman, W.M. et al. (2012) Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc. Natl Acad. Sci. U.S.A. 109, E1695–E1704 https://doi.org/10.1073/pnas.1201516109
    • (2012) Proc. Natl Acad. Sci. U.S.A. , vol.109 , pp. E1695-E1704
    • Babar, I.A.1    Cheng, C.J.2    Booth, C.J.3    Liang, X.4    Weidhaas, J.B.5    Saltzman, W.M.6
  • 45
    • 84920459959 scopus 로고    scopus 로고
    • Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
    • Gomez, I.G., MacKenna, D.A., Johnson, B.G., Kaimal, V., Roach, A.M., Ren, S. et al. (2015) Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J. Clin. Invest. 125, 141–156 https://doi.org/10.1172/JCI75852
    • (2015) J. Clin. Invest. , vol.125 , pp. 141-156
    • Gomez, I.G.1    MacKenna, D.A.2    Johnson, B.G.3    Kaimal, V.4    Roach, A.M.5    Ren, S.6
  • 47
    • 84901319289 scopus 로고    scopus 로고
    • Targeted delivery of miRNA therapeutics for cardiovascular diseases: Opportunities and challenges
    • Kwekkeboom, R.F.J., Lei, Z., Doevendans, P.A., Musters, R.J.P. and Sluijter, J.P.G. (2014) Targeted delivery of miRNA therapeutics for cardiovascular diseases: opportunities and challenges. Clin. Sci. 127, 351–365 https://doi.org/10.1042/CS20140005
    • (2014) Clin. Sci. , vol.127 , pp. 351-365
    • Kwekkeboom, R.F.J.1    Lei, Z.2    Doevendans, P.A.3    Musters, R.J.P.4    Sluijter, J.P.G.5
  • 48
    • 84923585184 scopus 로고    scopus 로고
    • MicroRNAs in myocardial infarction
    • Boon, R.A. and Dimmeler, S. (2015) MicroRNAs in myocardial infarction. Nat. Rev. Cardiol. 12, 135–142 https://doi.org/10.1038/nrcardio.2014.207
    • (2015) Nat. Rev. Cardiol. , vol.12 , pp. 135-142
    • Boon, R.A.1    Dimmeler, S.2
  • 51
    • 84879686595 scopus 로고    scopus 로고
    • Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction
    • Meloni, M., Marchetti, M., Garner, K., Littlejohns, B., Sala-Newby, G., Xenophontos, N. et al. (2013) Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction. Mol. Ther. 21, 1390–1402 https://doi.org/10.1038/mt.2013. 89
    • (2013) Mol. Ther. , vol.21 , pp. 1390-1402
    • Meloni, M.1    Marchetti, M.2    Garner, K.3    Littlejohns, B.4    Sala-Newby, G.5    Xenophontos, N.6
  • 52
    • 80051802344 scopus 로고    scopus 로고
    • MicroRNA-24 regulates vascularity after myocardial infarction
    • Fiedler, J., Jazbutyte, V., Kirchmaier, B.C., Gupta, S.K., Lorenzen, J., Hartmann, D. et al. (2011) MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124, 720–730 https://doi.org/10.1161/CIRCULATIONAHA.111.039008
    • (2011) Circulation , vol.124 , pp. 720-730
    • Fiedler, J.1    Jazbutyte, V.2    Kirchmaier, B.C.3    Gupta, S.K.4    Lorenzen, J.5    Hartmann, D.6
  • 53
    • 79952731167 scopus 로고    scopus 로고
    • MiR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes
    • Qian, L., Van Laake, L.W., Huang, Y., Liu, S., Wendland, M.F. and Srivastava, D. (2011) miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J. Exp. Med. 208, 549–560 https://doi.org/10.1084/jem.20101547
    • (2011) J. Exp. Med. , vol.208 , pp. 549-560
    • Qian, L.1    Van Laake, L.W.2    Huang, Y.3    Liu, S.4    Wendland, M.F.5    Srivastava, D.6
  • 54
    • 82155173518 scopus 로고    scopus 로고
    • MicroRNA regulation in angiogenesis
    • Caporali, A. and Emanueli, C. (2011) MicroRNA regulation in angiogenesis. Vascul. Pharmacol. 55, 79–86 https://doi.org/10.1016/j.vph.2011.06.006
    • (2011) Vascul. Pharmacol. , vol.55 , pp. 79-86
    • Caporali, A.1    Emanueli, C.2
  • 55
    • 84859753204 scopus 로고    scopus 로고
    • MicroRNAs in postischemic vascular repair
    • Caporali, A. and Emanueli, C. (2012) MicroRNAs in postischemic vascular repair. Cardiol. Res. Pract. 2012, 1–7 https://doi.org/10.1155/2012/486702
    • (2012) Cardiol. Res. Pract. , vol.2012 , pp. 1-7
    • Caporali, A.1    Emanueli, C.2
  • 56
    • 84921767137 scopus 로고    scopus 로고
    • Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia
    • Welten, S.M.J., Bastiaansen, A.J.N.M., de Jong, R.C.M., de Vries, M.R., Peters, E.A.B., Boonstra, M.C. et al. (2014) Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia. Circ. Res. 115, 696–708 https://doi.org/10.1161/CIRCRESAHA.114.304747
    • (2014) Circ. Res. , vol.115 , pp. 696-708
    • Welten, S.M.J.1    Bastiaansen, A.J.N.M.2    De Jong, R.C.M.3    De Vries, M.R.4    Peters, E.A.B.5    Boonstra, M.C.6
  • 57
    • 85014736062 scopus 로고    scopus 로고
    • Overcoming cellular barriers for RNA therapeutics
    • Dowdy, S.F. (2017) Overcoming cellular barriers for RNA therapeutics. Nat. Biotechnol. 35, 222–229 https://doi.org/10.1038/nbt.3802
    • (2017) Nat. Biotechnol. , vol.35 , pp. 222-229
    • Dowdy, S.F.1
  • 58
    • 84959507529 scopus 로고    scopus 로고
    • Evaluation of AAV-mediated gene therapy for central nervous system disease in canine mucopolysaccharidosis VII
    • Gurda, B.L., De Guilhem De Lataillade, A., Bell, P., Zhu, Y., Yu, H., Wang, P. et al. (2016) Evaluation of AAV-mediated gene therapy for central nervous system disease in canine mucopolysaccharidosis VII. Mol. Ther. 24, 206–216 https://doi.org/10.1038/mt.2015.189
    • (2016) Mol. Ther. , vol.24 , pp. 206-216
    • Gurda, B.L.1    De Guilhem De Lataillade, A.2    Bell, P.3    Zhu, Y.4    Yu, H.5    Wang, P.6
  • 59
    • 77954976233 scopus 로고    scopus 로고
    • Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: Implications for gene therapy using AAV vectors
    • Boutin, S., Monteilhet, V., Veron, P., Leborgne, C., Benveniste, O., Montus, M.F. et al. (2010) Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors. Hum. Gene Ther. 21, 704–712 https://doi.org/10.1089/hum.2009.182
    • (2010) Hum. Gene Ther. , vol.21 , pp. 704-712
    • Boutin, S.1    Monteilhet, V.2    Veron, P.3    Leborgne, C.4    Benveniste, O.5    Montus, M.F.6
  • 60
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • Manno, C.S., Pierce, G.F., Arruda, V.R., Glader, B., Ragni, M., Rasko, J.J. et al. (2006) Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12, 342–347 https://doi.org/10.1038/nm1358
    • (2006) Nat. Med. , vol.12 , pp. 342-347
    • Manno, C.S.1    Pierce, G.F.2    Arruda, V.R.3    Glader, B.4    Ragni, M.5    Rasko, J.J.6
  • 61
    • 44349170706 scopus 로고    scopus 로고
    • Analysis of AAV serotypes 1–9 mediated gene expression and tropism in mice after systemic injection
    • Zincarelli, C., Soltys, S., Rengo, G. and Rabinowitz, J.E. (2008) Analysis of AAV serotypes 1–9 mediated gene expression and tropism in mice after systemic injection. Mol. Ther. 16, 1073–1080 https://doi.org/10.1038/mt.2008.76
    • (2008) Mol. Ther. , vol.16 , pp. 1073-1080
    • Zincarelli, C.1    Soltys, S.2    Rengo, G.3    Rabinowitz, J.E.4
  • 62
    • 33645064807 scopus 로고    scopus 로고
    • Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors
    • Müller, O.J., Leuchs, B., Pleger, S.T., Grimm, D., Franz, W.-M., Katus, H.A. et al. (2006) Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovasc. Res. 70, 70–78 https://doi.org/10.1016/j.cardiores.2005.12.017
    • (2006) Cardiovasc. Res. , vol.70 , pp. 70-78
    • Müller, O.J.1    Leuchs, B.2    Pleger, S.T.3    Grimm, D.4    Franz, W.-M.5    Katus, H.A.6
  • 64
    • 84954288084 scopus 로고    scopus 로고
    • Materials for non-viral intracellular delivery of messenger RNA therapeutics
    • Kauffman, K.J., Webber, M.J. and Anderson, D.G. (2016) Materials for non-viral intracellular delivery of messenger RNA therapeutics. J. Control. Release 240, 227–234 https://doi.org/10.1016/j.jconrel.2015.12.032
    • (2016) J. Control. Release , vol.240 , pp. 227-234
    • Kauffman, K.J.1    Webber, M.J.2    Anderson, D.G.3
  • 65
    • 85010901146 scopus 로고    scopus 로고
    • Single-dose intracardiac injection of pro-regenerative microRNAs improves cardiac function after myocardial infarction
    • Lesizza, P., Prosdocimo, G., Martinelli, V., Sinagra, G., Zacchigna, S. and Giacca, M. (2017) Single-dose intracardiac injection of pro-regenerative microRNAs improves cardiac function after myocardial infarction. Circ. Res. 120, 1298–1304 https://doi.org/10.1161/CIRCRESAHA.116.309589
    • (2017) Circ. Res. , vol.120 , pp. 1298-1304
    • Lesizza, P.1    Prosdocimo, G.2    Martinelli, V.3    Sinagra, G.4    Zacchigna, S.5    Giacca, M.6
  • 66
    • 84864413702 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-delivery systems for cardiac repair: An overview
    • Simón-Yarza, T., Formiga, F.R., Tamayo, E., Pelacho, B., Prosper, F. and Blanco-Prieto, M.J. (2012) Vascular endothelial growth factor-delivery systems for cardiac repair: an overview. Theranostics 2, 541–552 https://doi.org/10.7150/thno.3682
    • (2012) Theranostics , vol.2 , pp. 541-552
    • Simón-Yarza, T.1    Formiga, F.R.2    Tamayo, E.3    Pelacho, B.4    Prosper, F.5    Blanco-Prieto, M.J.6
  • 67
    • 84964950525 scopus 로고    scopus 로고
    • Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes
    • Masotti, A., Miller, M.R., Celluzzi, A., Rose, L., Micciulla, F., Hadoke, P.W.F. et al. (2016) Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes. Nanomedicine 12, 1511–1522 https://doi.org/10.1016/j.nano.2016.02.017
    • (2016) Nanomedicine , vol.12 , pp. 1511-1522
    • Masotti, A.1    Miller, M.R.2    Celluzzi, A.3    Rose, L.4    Micciulla, F.5    Hadoke, P.W.F.6
  • 68
    • 84905718745 scopus 로고    scopus 로고
    • In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
    • Dahlman, J.E., Barnes, C., Khan, O., Thiriot, A., Jhunjunwala, S., Shaw, T.E. et al. (2014) In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat. Nanotechnol. 9, 648–655 https://doi.org/10.1038/nnano.2014.84
    • (2014) Nat. Nanotechnol. , vol.9 , pp. 648-655
    • Dahlman, J.E.1    Barnes, C.2    Khan, O.3    Thiriot, A.4    Jhunjunwala, S.5    Shaw, T.E.6
  • 69
    • 84964329578 scopus 로고    scopus 로고
    • MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation
    • Papangeli, I., Kim, J., Maier, I., Park, S., Lee, A., Kang, Y. et al. (2016) MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nat. Commun. 7, 11268 https://doi.org/10.1038/ncomms11268
    • (2016) Nat. Commun. , vol.7 , pp. 11268
    • Papangeli, I.1    Kim, J.2    Maier, I.3    Park, S.4    Lee, A.5    Kang, Y.6
  • 70
    • 84949946463 scopus 로고    scopus 로고
    • Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles
    • Kwekkeboom, R.F.J., Sluijter, J.P.G., van Middelaar, B.J., Metz, C.H., Brans, M.A. Kamp, O. et al. (2016) Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles. J. Control. Release 222, 18–31 https://doi.org/10.1016/j.jconrel.2015.11. 020
    • (2016) J. Control. Release , vol.222 , pp. 18-31
    • Kwekkeboom, R.F.J.1    Sluijter, J.P.G.2    Van Middelaar, B.J.3    Metz, C.H.4    Brans, M.A.5    Kamp, O.6
  • 71
    • 84910642232 scopus 로고    scopus 로고
    • Ultrasound and microbubble mediated drug delivery: Acoustic pressure as determinant for uptake via membrane pores or endocytosis
    • De Cock, I., Zagato, E., Braeckmans, K., Luan, Y., de Jong, N., De Smedt, S.C. et al. (2015) Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis. J. Control. Release 197, 20–28 https://doi.org/10.1016/j.jconrel.2014.10.031
    • (2015) J. Control. Release , vol.197 , pp. 20-28
    • De Cock, I.1    Zagato, E.2    Braeckmans, K.3    Luan, Y.4    De Jong, N.5    De Smedt, S.C.6
  • 72
    • 84949106628 scopus 로고    scopus 로고
    • Ultrasound-targeted microbubble destruction-mediated microRNA-21 transfection regulated PDCD4/NF-κB/TNF-α pathway to prevent coronary microembolization-induced cardiac dysfunction
    • Su, Q., Li, L., Liu, Y., Zhou, Y., Wang, J. and Wen, W. (2015) Ultrasound-targeted microbubble destruction-mediated microRNA-21 transfection regulated PDCD4/NF-κB/TNF-α pathway to prevent coronary microembolization-induced cardiac dysfunction. Gene Ther. 22, 1000–1006 https://doi.org/10.1038/gt.2015.59
    • (2015) Gene Ther , vol.22 , pp. 1000-1006
    • Su, Q.1    Li, L.2    Liu, Y.3    Zhou, Y.4    Wang, J.5    Wen, W.6
  • 73
    • 85019723959 scopus 로고    scopus 로고
    • Angiogenic gene therapy in cardiovascular diseases: Dream or vision?
    • Ylä-Herttuala, S., Bridges, C., Katz, M.G. and Korpisalo, P. (2017) Angiogenic gene therapy in cardiovascular diseases: dream or vision? Eur. Heart J. 38, 1365–1371 https://doi.org/10.1093/eurheartj/ehw547
    • (2017) Eur. Heart J. , vol.38 , pp. 1365-1371
    • Ylä-Herttuala, S.1    Bridges, C.2    Katz, M.G.3    Korpisalo, P.4
  • 74
    • 84973375350 scopus 로고    scopus 로고
    • Gene therapy for the treatment of heart failure: Promise postponed
    • Hulot, J.-S., Ishikawa, K. and Hajjar, R.J. (2016) Gene therapy for the treatment of heart failure: promise postponed. Eur. Heart J. 37, 1651–1658 https://doi.org/10.1093/eurheartj/ehw019
    • (2016) Eur. Heart J. , vol.37 , pp. 1651-1658
    • Hulot, J.-S.1    Ishikawa, K.2    Hajjar, R.J.3
  • 75
    • 84862018327 scopus 로고    scopus 로고
    • Gene delivery technologies for cardiac applications
    • Katz, M.G., Fargnoli, A.S., Pritchette, L.A. and Bridges, C.R. (2012) Gene delivery technologies for cardiac applications. Gene Ther. 19, 659–669 https://doi.org/10.1038/gt.2012.11
    • (2012) Gene Ther , vol.19 , pp. 659-669
    • Katz, M.G.1    Fargnoli, A.S.2    Pritchette, L.A.3    Bridges, C.R.4
  • 76
    • 84907662244 scopus 로고    scopus 로고
    • Intramyocardial cell delivery: Observations in murine hearts
    • Poggioli, T., Sarathchandra, P., Rosenthal, N. and Santini, M.P. (2014) Intramyocardial cell delivery: observations in murine hearts. J. Vis. Exp. 83, e51064 https://doi.org/10.3791/51064
    • (2014) J. Vis. Exp. , vol.83 , pp. e51064
    • Poggioli, T.1    Sarathchandra, P.2    Rosenthal, N.3    Santini, M.P.4
  • 77
    • 77955466812 scopus 로고    scopus 로고
    • Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease
    • Kajander, S., Joutsiniemi, E., Saraste, M., Pietila, M., Ukkonen, H., Saraste, A. et al. (2010) Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease. Circulation 122, 603–613 https://doi.org/10.1161/CIRCULATIONAHA.109.915009
    • (2010) Circulation , vol.122 , pp. 603-613
    • Kajander, S.1    Joutsiniemi, E.2    Saraste, M.3    Pietila, M.4    Ukkonen, H.5    Saraste, A.6
  • 78
    • 84989261706 scopus 로고    scopus 로고
    • Intramyocardial gene therapy directed to hibernating heart muscle using a combination of electromechanical mapping and positron emission tomography
    • Hassinen, I., Kivelä, A., Hedman, A., Saraste, A., Knuuti, J., Hartikainen, J.E. et al. (2016) Intramyocardial gene therapy directed to hibernating heart muscle using a combination of electromechanical mapping and positron emission tomography. Hum. Gene Ther. 27, 830–834 https://doi.org/10.1089/hum.2016.131
    • (2016) Hum. Gene Ther. , vol.27 , pp. 830-834
    • Hassinen, I.1    Kivelä, A.2    Hedman, A.3    Saraste, A.4    Knuuti, J.5    Hartikainen, J.E.6
  • 79
    • 78751660177 scopus 로고    scopus 로고
    • Pervasive roles of microRNAs in cardiovascular biology
    • Small, E.M. and Olson, E.N. (2011) Pervasive roles of microRNAs in cardiovascular biology. Nature 469, 336–342 https://doi.org/10.1038/nature09783
    • (2011) Nature , vol.469 , pp. 336-342
    • Small, E.M.1    Olson, E.N.2
  • 80
    • 78651308957 scopus 로고    scopus 로고
    • Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine
    • Bhattarai, S.R., Muthuswamy, E., Wani, A., Brichacek, M., Castañeda, A.L., Brock, S.L. et al. (2010) Enhanced gene and siRNA delivery by polycation-modified mesoporous silica nanoparticles loaded with chloroquine. Pharm. Res. 27, 2556–2568 https://doi.org/10.1007/ s11095-010-0245-0
    • (2010) Pharm. Res. , vol.27 , pp. 2556-2568
    • Bhattarai, S.R.1    Muthuswamy, E.2    Wani, A.3    Brichacek, M.4    Castañeda, A.L.5    Brock, S.L.6
  • 81
    • 84905262730 scopus 로고    scopus 로고
    • Improved vectors and genome-wide libraries for CRISPR screening
    • Sanjana, N.E., Shalem, O. and Zhang, F. (2014) Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783–784 https://doi.org/10.1038/nmeth.3047
    • (2014) Nat. Methods , vol.11 , pp. 783-784
    • Sanjana, N.E.1    Shalem, O.2    Zhang, F.3
  • 82
    • 85008257169 scopus 로고    scopus 로고
    • CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
    • Liu, S.J., Horlbeck, M.A., Cho, S.W., Birk, H.S., Malatesta, M., He, D. et al. (2017) CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science 355, eaah7111 https://doi.org/10.1126/science.aah7111
    • (2017) Science , vol.355 , pp. eaah7111
    • Liu, S.J.1    Horlbeck, M.A.2    Cho, S.W.3    Birk, H.S.4    Malatesta, M.5    He, D.6


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