Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction

Molecular Therapy

Volumn 21, Issue 7, 2013, Pages 1390-1402

  Meloni, Marco ^a   Marchetti, Micol ^a   Garner, Kathryn ^a   Littlejohns, Ben ^a   Sala Newby, Graciela ^a   Xenophontos, Natasa ^a   Floris, Ilaria ^a   Suleiman, M Saadeh ^a   Madeddu, Paolo ^a   Caporali, Andrea ^a   Emanueli, Costanza ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 24;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CAUSE OF DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; GENE EXPRESSION; GENE TARGETING; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; IN VITRO STUDY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY;

ADENOVIRIDAE; MUS;

EID: 84879686595     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.89     Document Type: Article

References (41)

1. Rosamond, W, Flegal, K, Friday, G, Furie, K, Go, A, Greenlund, K et al.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. (2007). Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115: e69-171.
2. Olivetti, G, Quaini, F, Sala, R, Lagrasta, C, Corradi, D, Bonacina, E et al. (1996). Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart. J Mol Cell Cardiol 28: 2005-2016. (Pubitemid 26340560)
3. Anversa, P, Cheng, W, Liu, Y, Leri, A, Redaelli, G and Kajstura, J (1998). Apoptosis and myocardial infarction. Basic Res Cardiol 93 Suppl 3: 8-12. (Pubitemid 29008240)
4. Sutton, MG and Sharpe, N (2000). Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101: 2981-2988. (Pubitemid 30415891)
5. Krichavsky, MZ and Losordo, DW (2011). Prevention and recovery of hibernating myocardium by microvascular repair. Circulation 124: 998-1000.
6. Henry, TD, Annex, BH, McKendall, GR, Azrin, MA, Lopez, JJ, Giordano, FJ et al.; VIVA Investigators. (2003). The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis. Circulation 107: 1359-1365. (Pubitemid 36350732)
7. Stewart, DJ, Kutryk, MJ, Fitchett, D, Freeman, M, Camack, N, Su, Y et al.; NORTHERN Trial Investigators. (2009). VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial. Mol Ther 17: 1109-1115.
8. Caporali, A and Emanueli, C (2011). MicroRNA regulation in angiogenesis. Vascul Pharmacol 55: 79-86.
9. Bartel, DP (2009). MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
10. Friedman, RC, Farh, KK, Burge, CB and Bartel, DP (2009). Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19: 92-105.
11. Bonauer, A, Carmona, G, Iwasaki, M, Mione, M, Koyanagi, M, Fischer, A et al. (2009). MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324: 1710-1713.
12. Fiedler, J, Jazbutyte, V, Kirchmaier, BC, Gupta, SK, Lorenzen, J, Hartmann, D et al. (2011). MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124: 720-730.
13. Wang, X, Zhang, X, Ren, XP, Chen, J, Liu, H, Yang, J et al. (2010). MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation 122: 1308-1318.
14. Qian, L, Van Laake, LW, Huang, Y, Liu, S, Wendland, MF and Srivastava, D (2011). miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med 208: 549-560.
15. Wang, JX, Jiao, JQ, Li, Q, Long, B, Wang, K, Liu, JP et al. (2011). miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med 17: 71-78.
16. Matkovich, SJ, Wang, W, Tu, Y, Eschenbacher, WH, Dorn, LE, Condorelli, G et al. (2010). MicroRNA-133a protects against myocardial fbrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res 106: 166-175.
17. Hu, S, Huang, M, Li, Z, Jia, F, Ghosh, Z, Lijkwan, MA et al. (2010). MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 122(11 Suppl): S124-S131.
18. van Rooij, E, Sutherland, LB, Thatcher, JE, DiMaio, JM, Naseem, RH, Marshall, WS et al. (2008). Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fbrosis. Proc Natl Acad Sci USA 105: 13027-13032.
19. Thum, T, Gross, C, Fiedler, J, Fischer, T, Kissler, S, Bussen, M et al. (2008). MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fbroblasts. Nature 456: 980-984.
20. Hu, S, Huang, M, Nguyen, PK, Gong, Y, Li, Z, Jia, F et al. (2011). Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation. Circulation 124(11 Suppl): S27-S34.
21. Wang, J, Huang, W, Xu, R, Nie, Y, Cao, X, Meng, J et al. (2012). MicroRNA-24 regulates cardiac fbrosis after myocardial infarction. J Cell Mol Med 16: 2150-2160.
22. Caporali, A, Meloni, M, Völlenkle, C, Bonci, D, Sala-Newby, GB, Addis, R et al. (2011). Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation 123: 282-291.
23. Kiriakidou, M, Nelson, PT, Kouranov, A, Fitziev, P, Bouyioukos, C, Mourelatos, Z et al. (2004). A combined computational-experimental approach predicts human microRNA targets. Genes Dev 18: 1165-1178. (Pubitemid 38669037)
24. Gill, C, Mestril, R and Samali, A (2002). Losing heart: the role of apoptosis in heart disease-a novel therapeutic target? FASEB J 16: 135-146. (Pubitemid 34113007)
25. Meloni, M, Caporali, A, Graiani, G, Lagrasta, C, Katare, R, Van Linthout, S et al. (2010). Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res 106: 1275-1284.
26. Park, M, Shen, YT, Gaussin, V, Heyndrickx, GR, Bartunek, J, Resuello, RR et al. (2009). Apoptosis predominates in nonmyocytes in heart failure. Am J Physiol Heart Circ Physiol 297: H785-H791.
27. Lutgens, E, Daemen, MJ, de Muinck, ED, Debets, J, Leenders, P and Smits, JF (1999). Chronic myocardial infarction in the mouse: cardiac structural and functional changes. Cardiovasc Res 41: 586-593. (Pubitemid 29130622)
28. Zhao, Y, Ransom, JF, Li, A, Vedantham, V, von Drehle, M, Muth, AN et al. (2007). Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129: 303-317. (Pubitemid 46574975)
29. Zhao, Y, Samal, E and Srivastava, D (2005). Serum response factor regulates a muscle-specifc microRNA that targets Hand2 during cardiogenesis. Nature 436: 214-220. (Pubitemid 41021266)
30. Morton, SU, Scherz, PJ, Cordes, KR, Ivey, KN, Stainier, DY and Srivastava, D (2008). microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci USA 105: 17830-17835.
31. Cordes, KR and Srivastava, D (2009). MicroRNA regulation of cardiovascular development. Circ Res 104: 724-732.
32. Carè, A, Catalucci, D, Felicetti, F, Bonci, D, Addario, A, Gallo, P et al. (2007). MicroRNA-133 controls cardiac hypertrophy. Nat Med 13: 613-618. (Pubitemid 46828487)
33. Eulalio, A, Mano, M, Dal Ferro, M, Zentilin, L, Sinagra, G, Zacchigna, S et al. (2012). Functional screening identifes miRNAs inducing cardiac regeneration. Nature 492: 376-381.
34. Ebert, MS, Neilson, JR and Sharp, PA (2007). MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 4: 721-726. (Pubitemid 47338166)
35. van Rooij, E, Purcell, AL and Levin, AA (2012). Developing microRNA therapeutics. Circ Res 110: 496-507.
36. Larsson, E, Fredlund Fuchs, P, Heldin, J, Barkefors, I, Bondjers, C, Genové, G et al. (2009). Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med 1: 108.
37. Murohara, T, Asahara, T, Silver, M, Bauters, C, Masuda, H, Kalka, C et al. (1998). Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 101: 2567-2578. (Pubitemid 28270451)
38. Schrage, A, Loddenkemper, C, Erben, U, Lauer, U, Hausdorf, G, Jungblut, PR et al. (2008). Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1. Histochem Cell Biol 129: 441-451.
39. Claycomb, WC, Lanson, NA Jr, Stallworth, BS, Egeland, DB, Delcarpio, JB, Bahinski, A et al. (1998). HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci USA 95: 2979-2984. (Pubitemid 28135840)
40. Bonci, D, Coppola, V, Musumeci, M, Addario, A, Giuffrida, R, Memeo, L et al. (2008). The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 14: 1271-1277.
41. Sala-Newby, GB, Freeman, NV, Curto, MA and Newby, AC (2003). Metabolic and functional consequences of cytosolic 5'-nucleotidase-IA overexpression in neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol 285: H991-H998. (Pubitemid 37048152)