Intramyocardial cell delivery: Observations in murine hearts

Journal of Visualized Experiments

Volumn , Issue 83, 2014, Pages

  Poggioli, Tommaso ^a,b   Sarathchandra, Padmini ^a,b   Rosenthal, Nadia ^b,c   Santini, Maria P ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c Monash University   (Australia)

Author keywords

Cell therapy; Fibrotic tissue; Grafting; Heart; Intramyocardial cell injection; Issue 83; Medicine; Stem cells

Indexed keywords

ANIMAL; ANIMAL MODEL; ARTICLE; CYTOLOGY; HEART; HEART MUSCLE; HEK293 CELL LINE; HUMAN; IMMUNOCOMPROMISED PATIENT; METHODOLOGY; MOUSE; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; STEM CELL TRANSPLANTATION;

ANIMALS; HEART; HEK293 CELLS; HUMANS; IMMUNOCOMPROMISED HOST; MICE; MICE, INBRED NOD; MODELS, ANIMAL; MYOCARDIUM; STEM CELL TRANSPLANTATION;

EID: 84907662244     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/51064     Document Type: Article

References (41)

1. Menasche, P. et al. Myoblast transplantation for heart failure. Lancet. 357, 279-280 (2001).
2. Taylor, D. A. et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. 4, 929-933 (1998).
3. Suzuki, K. et al. Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts. Circulation. 104, I207-212 (2001).
4. Suzuki, K. et al. Targeted cell delivery into infarcted rat hearts by retrograde intracoronary infusion: distribution, dynamics, and influence on cardiac function. Circulation. 110, II225-230 (2004).
5. Robinson, S. W. et al. Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: long-term survival and phenotypic modification of implanted myoblasts. Cell Transplant. 5, 77-91 (1996).
6. Muller-Ehmsen, J. et al. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J. Mol. Cell Cardiol. 34, 107-116 (2002).
7. Reinecke, H., Zhang, M., Bartosek, T. & Murry, C. E. Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. Circulation. 100, 193-202 (1999).
8. Dimmeler, S., Zeiher, A. M. & Schneider, M. D. Unchain my heart: the scientific foundations of cardiac repair. J. Clin. Invest. 115, 572-583 (2005).
9. Oettgen, P., Boyle, A. J., Schulman, S. P. & Hare, J. M. Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety Monitoring. Circulation.114, 353-358 (2006).
10. Krause, K. et al. Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study. Heart. 95, 1145-1152 (2009).
11. Rodrigo, S. F. et al. Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. Am. Heart J. 164, 771-778 (2012).
12. Smith, R. R. et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation. 115, 896-908 (2007).
13. Sadek, H. A., Martin, C. M., Latif, S. S., Garry, M. G. & Garry, D. J. Bone-marrow-derived side population cells for myocardial regeneration. J. Cardiovasc. Transl. Res. 2, 173-181 (2009).
14. Messina, E. et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res. 95, 911-921 (2004).
15. Malliaras, K. et al. Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation. 125, 100-112 (2012).
16. Beltrami, A. P. et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 114, 763-776 (2003).
17. Bearzi, C. et al. Identification of a coronary vascular progenitor cell in the human heart. Proc. Natl. Acad. Sci. U.S.A. 106, 15885-15890 (2009).
18. Hare, J. M. et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA. 308, 2369-2379 (2012).
19. Makkar, R. R. et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet. 379, 895-904 (2012).
20. Bolli, R. et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 378, 1847-1857 (2011).
21. Brunt, K. R., Weisel, R. D. & Li, R. K. Stem cells and regenerative medicine-future perspectives. Can. J. Physiol. Pharmacol. 90, 327-335 (2012).
22. Laflamme, M. A. et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat. Biotechnol. 25, 1015-1024 (2007).
23. van Laake, L. W. et al. Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res. 1, 9-24 (2007).
24. Leobon, B. et al. Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc. Natl. Acad. Sci. U.S.A. 100, 7808-7811 (2003).
25. Huang, X. P. et al. Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation. 122, 2419-2429 (2010).
26. Reinecke, H., Poppa, V. & Murry, C. E. Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J. Mol. Cell Cardiol.34, 241-249 (2002).
27. Springer, M. L. et al. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am. J. Physiol. Heart Circ. Physiol.289, H1307-1314 (2005).
28. Hamdi, H. et al. Cell delivery: intramyocardial injections or epicardial deposition? A head-to-head comparison. Ann. Thorac. Surg. 87, 1196-1203 (2009).
29. Terrovitis, J. V., Smith, R. R. & Marban, E. Assessment and optimization of cell engraftment after transplantation into the heart. Circ. Res. 106, 479-494 (2008).
30. Kehat, I. et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat. Biotechnol. 22, 1282-1289 (2004).
31. van Laake, L. W. et al. Improvement of mouse cardiac function by hESC-derived cardiomyocytes correlates with vascularity but not graft size. Stem Cell Res. 3, 106-112 (2009).
32. Fernandes, S. et al. Autologous myoblast transplantation after myocardial infarction increases the inducibility of ventricular arrhythmias. Cardiovasc. Res. 69, 348-358 (2006).
33. Scherschel, J. A., Soonpaa, M. H., Srour, E. F., Field, L. J. & Rubart, M. Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium. Mol. Ther. 16, 1129-1137 (2008).
34. Wei, F. et al. Mesenchymal stem cells neither fully acquire the electrophysiological properties of mature cardiomyocytes nor promote ventricular arrhythmias in infarcted rats. Basic Res. Cardiol. 107, 274 (2012).
35. Fukushima, S. et al. Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. Circulation. 115, 2254-2261 (2007).
36. Bartunek, J. et al. Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation. 112, I178-183 (2005).
37. Britten, M. B. et al. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation. 108, 2212-2218 (2003).
38. Smits, P. C. et al. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up. J. Am. Coll. Cardiol. 42, 2063-2069 (2003).
39. Kang, H. J. et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet. 363, 751-756 (2004).
40. Fernandez-Aviles, F. et al. Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ. Res. 95, 742-748 (2004).
41. Vulliet, P. R., Greeley, M., Halloran, S. M., MacDonald, K. A. & Kittleson, M. D. Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet. 363, 783-784 (2004).