Increased local delivery of antagomir therapeutics to the rodent myocardium using ultrasound and microbubbles

Journal of Controlled Release

Volumn 222, Issue , 2016, Pages 18-31

  Kwekkeboom, Rick F J ^a,c   Sluijter, Joost P G ^b   Van Middelaar, Ben J ^b   Metz, Corina H ^b   Brans, Maike A ^b   Kamp, Otto ^a,c   Paulus, Walter J ^a,b,c   Musters, René J P ^a,c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Antagomir; Cardiovascular; Drug delivery; Ischemia reperfusion; Microbubbles; MicroRNA; Ultrasound

Indexed keywords

CELL DEATH; DRUG DELIVERY; HEART; ULTRASONICS;

ANTAGOMIR; CARDIOVASCULAR; ISCHEMIA REPERFUSION; MICROBUBBLES; MICRORNAS;

RNA;

ANTAGOMIR; MICRORNA; TROPONIN I; OLIGONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL INVASION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ELECTROCARDIOGRAM; HEART MUSCLE; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; MALE; MICROBUBBLE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE; TISSUE DISTRIBUTION; ULTRASOUND; ULTRASOUND TRIGGERED MICROBUBBLE DESTRUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CARDIAC MUSCLE; METABOLISM;

ANIMALS; DRUG DELIVERY SYSTEMS; MALE; MICE, INBRED C57BL; MICROBUBBLES; MICRORNAS; MYOCARDIUM; OLIGONUCLEOTIDES; REPERFUSION INJURY; ULTRASONIC WAVES;

EID: 84949946463     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.11.020     Document Type: Article

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