Microbial production of oils and fats

Food Biotechnology, Second Edition

Volumn , Issue , 2005, Pages 443-472

  Wynn, James P ^a   Ratledge, Colin ^b  

^a Martek Biosciences Corporation   (United States)

^b UNIVERSITY OF HULL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85045851946     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (75)

1. Whitworth, D.A., C. Ratledge. Microorganisms as a potential source of oils and fats. Proc. Biochem. 9(9):14-22, 1974.
2. Ratledge, C. Microbial production of oils and fats. In: Food from Waste, Birch, G.G., K.J. Palmer, J.T. Worgan, eds., London: Applied Science 1976, pp 98-113.
3. Lundin, H. Fat synthesis by microorganisms and its possible applications in industry. J. Inst. Brew. 56:17-28, 1950.
4. Woodbine, M. Microbial fat: microorganisms as potential fat producers. Prog. Ind. Microbiol. 1:179-245, 1959.
5. Ratledge, C. Biotechnology as applied to the oils and fats industry. Fette Sifen Anstrichmittel 86:379-389, 1984.
6. Thorpe, R.F., C. Ratledge. Fatty acid distribution in triglycerides of yeasts grown on glucose or n-alkanes. J. Gen. Microbiol. 72:151-163, 1972.
7. Ratledge, C., S.G. Wilkinson. Microbial Lipids, vols. 1, 2. London: Academic Press, 1989, 1990.
8. Ratledge, C. Yeasts, moulds, algae and bacteria as sources of lipids. In: Tehcnological Advances in Improved and Alternative Sources of Lipids, Kamel, B.S., Y. Kakuda, eds., Glasgow: Blackie & Sons, 1994, pp 235-291.
9. Ratledge, C. Microbial lipids. In: Biotechnology, vol. 7: Products of Secondary Metabolism, 2nd ed., Rehm, H.J., R. Reed, A. Puhler, P. Stadler, H. Kleinhauf, H. von Dohren, eds., Weinheim, Germany: VCH, pp 133-197.
10. Ratledge, C. Microorganisms as sources of polyunsaturated fatty acids. In: Structured and Modified Lipids, Gunstone, F.D., ed., New York: Marcel-Dekker, 2001, pp 351-399.
11. Anderson, A.J., J.P. Wynn. Microbial polyhydroxyalkanoates, polysaccharides and lipids. In: Basic Biotechnology, 2nd ed., Ratledge, C., B. Kristiansen, eds., London: Cambridge University Press, 2001, pp 325-348.
12. Kubicek, C.P. Organic acids. In: Basic Biotechnology, 2nd ed., Ratledge, C., B. Kristiansen, eds., London: Cambridge University Press, 2001, pp 305-324.
13. Ratledge, C., J.P. Wynn. The biochemistry and molecular biology of lipid accumulation in oleaginous microorganisms. Adv. Appl. Microbiol. 51: 1-51, 2002.
14. Ratledge, C., H. Streekstra, Z. Cohen. Processing Aspects of Single Cell Oils. In: Nutritionally Enhanced Edible Oil Processing, Dunford, N.T., H.B. Dunford, eds., Champaign, IL: AOCS Press, 2004, in press.
15. Kyle, D.J., C. Ratledge. Industrial Applications of Single Cell Oils. Champaign, IL: AOCS Press, 1992.
16. Davies, J. Scale up of yeast technology. In: Industrial Applications of Single Cell Oils, Kyle, D.J., C. Ratledge, Champaign, IL: AOCS Press, 1992, pp 196-218.
17. Smit, H., A. Ykema, E.C. Verbree, I.I.G.S. Verwoert, M.M. Kater. Production of cocoa butter equivalents by yeast mutants. In Industrial Applications of Single Cell Oils, Kyle, D.J., C. Ratledge, Champaign, IL: AOCS Press, 1992, pp 185-195.
18. Zhou, B. Studies on the biochemistry of malic enzyme in Mucor circinelloides. MSc Thesis, University of Hull, UK, 2004.
19. Broadhurst, C.L., Y. Wang, M.A. Crawford, S.C. Cunnane, J.E. Parkington, W.F. Schmidt. Brain-specific lipids from marine, lacustrine, or terrestrial food resources: potential impact on early Homo sapiens. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 131: 653-673, 2002.
20. Hornstra, G. Essential fatty acids in mothers and their neonates. Am. J. Clin. Nutr. 71: 1262S-1269S, 2000.
21. Barclay, W.R. Process for the heterotrophic production of products with high concentrations of omega-3 highly unsaturated fatty acids. Patent No. WO9107498, 1991.
22. Huang, Y.S., D.E. Mills. γ-Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine. Champaign, IL: AOCS Press, 1996.
23. Huang, Y.S., A. Ziboh. y-Linolenic Acid: Recent Advances in Biotechnology & Clinical Applications. Champaign, IL: AOCS, 2001.
24. Shaw, R. The occurrence of gamma-linolenic acid in fungi. Biochim. Biophys. Acta 98: 230-237, 1965.
25. Shaw, R. The polyunsaturated fatty acids of microorganisms. Adv. Lipid Res. 4:107-174, 1966.
26. Nakahara, T., T. Yokocki, Y. Kamisaka, O. Suzuki. Gamma-linolenic acid from genus Mortierella. In: Industrial Applications of Single Cell Oils, Kyle, D.J., C. Ratledge, Champaign, IL: AOCS Press, 1992, pp 61-97.
27. Lion Corporation. External preparation for skin. Japanese patent No. 64-38007, 1988.
28. Kyle, D.J. Arachidonic acid and methods for the production and use thereof. Patent No. WO0213086, 1992.
29. Stredanska, S., J. Sajbador. Oligounsaturated fatty acid production by selected strains of micromycetes. Folia. Microbiol. 37:357-359, 1992.
30. Shinmen, Y., S. Shimizu, K. Akimoto, H. Kawashima, H. Yamada. Production of arachidonic acid by Mortierella fungi: selection of a potent producer and optimization of culture conditions for large scale. Appl. Microbiol. Biotechnol. 31:11-16, 1989.
31. Bajpai, P., P.K. Bajpai, O.P. Ward. Eicosapentaenoic acid (EPA) production by Mortierella alpina ATCC 32222. Appl. Biochem. Biotechnol. 31: 267-272, 1991.
32. Singh, A., O.P. Ward. Production of high yields of arachidonic acid in a fed batch system by Mortierella alpina ATCC 32222. Appl. Microbiol. Biotechnol. 48: 1-5, 1997.
33. Streekstra, H. On the safety of Mortierella alpina for the production of food ingredients, such as arachidonic acid. J. Biotechnol. 56:153-165, 1997.
34. Higashiyama, K., T. Yagushi, K. Akimoto, S. Fujikawa, S. Shimizu. Effects of mineral addition on the growth morphology of and arachidonic acid production by Mortierella alpina 1S-4. J. Am. Oil Chem. Soc. 75:1815-1819, 1998.
35. Park, E.Y., Y. Koike, K. Higashiyama, S. Fujikawa, M. Okabe. Effect of nitrogen source on mycelial morphology and arachidonic acid production in cultures of Mortierella alpina. J. Biosci. Bioeng. 88: 61-67, 1999.
36. Yamada, H., S. Shimizu, Y. Shinman, K. Akimoto, H. Kawashima, S. Jareonkitmongkol. Production of dihomo-y-linolenic acid, arachidonic acid and eicosapentaenoic acid by filamentous fungi. In: Industrial Applications of Single Cell Oils, Kyle, D.J., C. Ratledge, Champaign, IL: AOCS Press, 1992, p 118-138.
37. Wolf, J.H., A. Schaaf, H.L. Bijl, J.M.J. Visser. Preparation of microbial fatty acid containing oil from pasteurized biomass. Patent No. US6441208, 2001.
38. Kyle, D.J., S.E. Reeb, V.J. Silcotte. Docosahexaenoic acid, methods for its production and compounds containing the same. Patent No. WO91/11918, 1991.
39. Tuttle, R.C.,A.R. Loeblich. An optimal growth medium for the dinoflagellate Crypthecodinium cohnii. Phycologia 14:1-8, 1975.
40. Beach, D.H., G.G. Holz. Environmental influences on the docosahexaenate content of the triacylgycerols and phosphatidylcholine of a heterotrophic marine dinoflagellate Crypthecodinium cohnii. Biochim. Biophys. Acta 316:56-65, 1973.
41. Kendrick, A., C. Ratledge. Lipids in selected molds grown for the production of n-3 and n-6 polyunsaturated fatty acids. Lipids 27:15-20, 1992.
42. Russell, N.J., D.S. Nichols. Polyunsaturated fatty acids in marine bacteria: a dogma rewritten. Microbiology 145:767-779, 1999.
43. Van Pelt, C., M.-C. Huang, C.L. Tshanz, J.T. Brenna. An octaene fatty acid, 4,7,10,13,16,19,22,25-octacosaoctaenoic acid (28:8n-3), found in marine oils. J. Lipid Res. 40:1501-1505, 1999.
44. Barclay, W.R., P. Mirrasoul, G.T. Weeder, T. Kaneko, D. Dimasi, J. Hansen, C.M. Reuker, R.B. Bailey. Enhanced production of lipids containing polyenoic afatty acids by high density cultures of eukaryotic microbes in fermentors. Patent WO0154510, 2001.
45. Molina Grima, E., E.-H. Elardi, F.G. Acien Fernandez, A. Robles Medina, Y. Chisti. Recovery of microalgal biomass and metabolites: process options and economics. Biotechnol. Adv. 20:491-515, 2003.
46. De Swaaf, M., L. Sijtsma, J.T. Pronk. High-cell-density fed-batch cultivation of the docosahexaenoic acid producing marine alga Crypthecodinium cohnii. Biotechnol. Bioeng. 81:666-672, 2003.
47. Barclay, W.R. Process for growing Thraustochytrium and Schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3 highly unsaturated fatty acids. U.S. Patent 5,340,742, 1994.
48. Seyberth, H.W., O. Oelz, T. Kenedy, B.J. Sweetman, A. Danon, J.C. Frolich, H. Heimberg, J.A. Oates. Increased arachidonate in lipids after administration to man. Clin. Pharmacol. Therapeu. 18:521-529, 1975.
49. Anon. A human dietary arachidonic acid supplementation study conducted in a metabolic unit. Lipids 32:413-456, 1997.
50. Nelson, G.J., D.S. Kelley, E.A. Emken, S.D. Phinney, D. Kyle, A. Ferretti. A human dietary arachidonic acid supplementation study conducted in a metabolic research unit: rationale and design. Lipids 32:415-420, 1997.
51. Nelson, G.J., P.C. Schmidt, G. Bartolini, D.S. Kelley, D. Kyle. The effect of dietary arachidonic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 32:421-425, 1997.
52. Nelson, G.J., P.C. Schmidt, G. Bartolini, D.S. Kelley, S.D. Phinney, D. Kyle, S. Silbermann, E.J. Schaefer. The effect of dietary arachidonic acid on plasma lipoprotein distributions, apoproteins, blood lipid levels and tissue fatty acid compositions in humans. Lipids 32:427-433, 1997.
53. Kelley, D.S., P.C. Taylor, G.J. Nelson, P.C. Schmidt, B.C. Mackey, D. Kyle. Effects of dietary arachidonic acid on human immune response. Lipids 32:449-456, 1997.
54. Hempenius, R.A., J.M.H. Van Delft, M. Prinzen, B.A.R. Lina. Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data. Food Chem. Toxicol. 35: 573-581, 1997.
55. Hempenius, R.A., B.A.R. Lina, R.C. Haggit. Evaluation of a subchronic (13 week) oral toxicological study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats. Food Chem. Toxicol. 38:127-139, 2000.
56. Grandjean, P., P. Weihe. Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure. Am. J. Clin. Nutr. 77:715-719, 2003.
57. Falandysz, J., S. Tanabe, R. Tatsukawa. Most toxic and highly bioaccumulative PCB congeners in cod-liver oil of Baltic origin processed in Poland during the 1970s and 1980s, their TEQ-values and possible intake. Sci. Total Environ. 145:207-212, 1994.
58. Arterburn, L.M., K.D. Boswell, T. Lawlor, M.A. Cifone, H. Murli, D.J. Kyle. In vitro genotoxicity testing of ARASCO and DHASCO oils. Food Chem. Toxicol. 38: 971-976, 2000.
59. Boswell, K., E.-K. Koskelo, L. Carl, S. Glaza, D.J. Hensen, K.D. Williams, D.J. Kyle. Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid. Food Chem. Toxicol. 34:585-593, 1996.
60. Arterburn, L.M., K.D. Boswell, E. Koskelo, S.L. Kassner, C. Kelly, D.J. Kyle. A combined subchronic (90-day) toxicity and neurotoxicity study of a single-cell source of docosahexaenoic acid triglyceride (DHASCO oil). Food Chem. Toxicol. 38: 35-49, 2000.
61. Burns, R.A., G.J. Wibert, D.A. Diersen-Schade, C.M. Kelly. Evaluation of single-cell sources of docosahexaenoic acid and arachidonic acid: 3-month rat oral safety study with an in utero phase. Food Chem. Toxicol. 37:23-36, 1999.
62. Arterburn, L.M., K.D. Boswell, S.M. Henwood, D.J. Kyle. A developmental safety study in rats using DHA- and ARA-rich single-cell oils. Food Chem. Toxicol. 38:763-771, 2000.
63. Agren, J.J., S. Vaisanen, O. Hanninen, A.D. Muller, G. Hornstra. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. Prostaglandins Leukot. Essent. Fatty Acids 57:419-421, 1997.
64. Conquer, J.A., B.J. Holub. Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. J. Nutr. 126:3032-3039, 1996.
65. Nelson, G.J., P.S. Schmidt, G.L. Bartolini, D.S. Kelley, D. Kyle. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids 32:1129-1136, 1997.
66. Kelley, D.S., P.C. Taylor, G.J. Nelson, B.E. Mackey. Dietary docosahexaenoic acid and immunocompetence in young healthy men. Lipids 33:559-566, 1998.
67. Innis, S.M., J.W. Hansen. Plasma fatty acid responses, metabolic effects and safety of micro-algal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. Am. J. Clin. Nutr. 64:159-167, 1996.
68. Otto, S.J., A.C. van Houwelingen, G. Hornstra. The effect of different supplements containing docosahexaenoic acid on plasma and erythrocyte fatty acids of healthy non-pregnant women. Nutr. Res. 20:917-927, 2000.
69. Abril, R., J. Garrret, S.G. Zeller, W.J. Sander, R.W. Mast. Safety assessment of DHA-rich microalgae from Schizochytrium sp, part V: target animal safety/toxicity study in growing swine. Regul. Toxicol. Pharmacol. 37:73-82, 2003.
70. Hammond, B.G., D.A. Mayhew, M.W. Naylor, F.A. Rueker, R.W. Mast, W.J. Sander. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Regul. Toxicol. Pharmacol. 33:192-204, 2001.
71. Hammond, B.G., D.A. Mayhew, J.F. Holson, M.D. Nemec, R.W. Mast, W.J. Sander, Safety assessment of DHA-rich microalgae from Schizochytrium sp. Regul. Toxicol. Pharmacol. 33:205-217, 2001b.
72. Hammond, B.G., Mayhew, D.A., K. Robinson, R.W. Mast, W.J. Sander. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Regul. Toxicol. Pharmacol. 33:356-362, 2001.
73. Hammond, B.G., D.A. Mayhew, L.D. Kier, R.W. Mast, W.J. Sander. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Regul. Toxicol. Pharmacol. 35:255-265, 2002.
74. Kroes, R., E.J. Schaefer, R.A. Squire, G.M. Williams. A review of the safety of DHA45-oil. Food Chem. Toxicol. 41:1433-1446, 2003.
75. Wynn, J.P., C. Ratledge. Microbial Oils and Fats. In: Bailey's Encyclopedia of Industrial Oil and Fat Products, 6th ed., Shahidi, F., ed., Hoboken, NJ: J. Wiley, in press.