Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure

American Journal of Clinical Nutrition

Volumn 77, Issue 3, 2003, Pages 715-719

  Grandjean, Philippe ^a,b   Weihe, Pál ^a,c  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b BOSTON UNIVERSITY   (United States)

^c Faroese Hospital System   (Denmark)

Author keywords

Arachidonic acid; Faroe Islands; Fatty acid desaturases; Fatty acids; Long chain polyunsaturated fatty acids; Maternal fetal exchange; Polychlorinated biphenyls

Indexed keywords

ARACHIDONIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LONG CHAIN FATTY ACID; POLYCHLORINATED BIPHENYL; POLYUNSATURATED FATTY ACID;

ADULT; ARACHIDONIC ACID METABOLISM; ARTICLE; CORRELATION ANALYSIS; ENZYME INHIBITION; FATTY ACID BLOOD LEVEL; FEMALE; FOOD CONTAMINATION; FOOD INTAKE; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL BLOOD; NEWBORN; PREGNANCY; PRENATAL EXPOSURE; SAFETY; SEA FOOD; UMBILICAL CORD BLOOD;

CETACEA;

EID: 0037369586     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/77.3.715     Document Type: Article

References (32)

1. Hearn TL, Sgoutas SA, Hearn JA, Sgoutas DS. Polyunsaturated fatty acids and fat in fish flesh for selecting species for health benefits. J Food Sci 1987;52:1209-11.
2. Hornstra G. Essential fatty acids in mothers and their neonates. Am J Clin Nutr 2000;71(suppl):1262S-9S.
3. Carlson SE, Werkman SH, Peeples JM, Cooke RJ, Tolley EA. Arachidonic acid status correlates with first year growth in preterm infants. Proc Natl Acad Sci U S A 1993;90:1073-7.
4. Bønaa KH, Bjerve KS, Nordøy A. Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Tromsø study. Am J Clin Nutr 1992;55:1126-34.
5. Sanjurjo P, Matorras R, Perteagudo L. Influence of fatty fish intake during pregnancy in the polyunsaturated fatty acids of erythrocyte phospholipids in the mother at labor and newborn infant. Acta Obstet Gynecol Scand 1995;74:594-8.
6. Andersen LF, Solvoll K, Drevon CA. Very-long-chain n-3 fatty acids as biomarkers for intake of fish and n-3 fatty acid concentrates. Am J Clin Nutr 1996;64:305-11.
7. Carlson SE, Cooke RJ, Werkman SH, Tolley EA. First year growth of preterm infants fed standard compared to marine oil n-3 supplemented formula. Lipids 1992;27:901-7.
8. Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH. Addition of eicosapentaenoic acid to gamma-linolenic acidsupplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 2000;130:1925-31.
9. de March BGE, de Wit CA, Muir DCG. Persistent organic pollutants. In: AMAP assessment report: arctic pollution issues. Oslo: Arctic Monitoring and Assessment Programme, 1998:183-371.
10. Sauer PJJ, Huisman M, Koopman-Esseboom C, et al. Effects of polychlorinated biphenyls (PCBs) and dioxins on growth and development. Hum Exp Toxicol 1994;13:900-6.
11. Grandjean P, Weihe P, Burse VW, et al. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol 2001;23:305-17.
12. Matsusue K, Ishii Y, Ariyoshi N, Oguri K. A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. Toxicol Lett 1997;91:99-104.
13. Matsusue K, Ishii Y, Ariyoshi N, Oguri K. A highly toxic coplanar polychlorinated biphenyl compound suppresses Delta5 and Delta6 desaturase activities which play key roles in arachidonic acid synthesis in rat liver. Chem Res Toxicol 1999;12:1158-65.
14. Koletzko B, Decsi T, Demmelmair H. Arachidonic acid supply and metabolism in human infants born at full term. Lipids 1996;31:79-83.
15. Rodriguez A, Sarda P, Nessmann C, et al. Fatty acid desaturase activities and polyunsaturated fatty acid composition in human liver between the seventeenth and thirty-sixth gestational weeks. Am J Obstet Gynecol 1998;179:1063-70.
16. Steuerwald U, Weihe P, Jørgensen PJ, et al. Maternal seafood diet, methylmercury exposure, and neonatal neurological function. J Pediatr 2000;136:599-605.
17. Grandjean P, Bjerve KS, Weihe P, Steuerwald U. Birth weight in a fishing community: significance of essential fatty acids and marine food contaminants. Int J Epidemiol 2001;30:1272-8.
18. Bjerve KS, Fischer S, Alme K. Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. Am J Clin Nutr 1987; 46:570-6.
19. Brock J, Burse VW, Ashley DL, et al. An improved analysis for chlorinated pesticides and polychlorinated biphenyls (PCBs) in human and bovine sera using solid-phase extraction. J Anal Toxicol 1996; 20:528-36.
20. Grandjean P, Weihe P, Needham LL, et al. Effect of a seafood diet on mercury, selenium, arsenic, and PCBs and other organochlorines in human milk. Environ Res 1995;71:29-38.
21. Al MD, van Houwelingen AC, Kester AD, Hasaart TH, de Jong AE, Hornstra G. Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. Br J Nutr 1995;74:55-68.
22. Otto SJ, Houwelingen AC, Antal M, et al. Maternal and neonatal essential fatty acid status in phospholipids: an international comparative study. Eur J Clin Nutr 1997;51:232-42.
23. Ghebremeskel K, Crawford MA, Lowy C, et al. Arachidonic and docosahexaenoic acids are strongly associated in maternal and neonatal blood. Eur J Clin Nutr 2000;54:50-6.
24. Nakamura MT, Cho HP, Xu J, Tang Z, Clarke SD. Metabolism and functions of highly unsaturated fatty acids: an update. Lipids 2001; 36:961-4.
25. Sanders TA, Reddy S. The influence of a vegetarian diet on the fatty acid composition of human milk and the essential fatty acid status of the infant. J Pediatr 1992;120:S71-7.
26. Guitart R, Guerrero X, Silvestre AM, Gutierrez JM, Mateo R. Organochlorine residues in tissues of striped dolphins affected by the 1990 Mediterranean epizootic: relationships with the fatty acid composition. Arch Environ Contam Toxicol 1996;30: 79-83.
27. Hassoun EA, Li F, Abushaban A, Stohs SJ. Production of superoxide anion, lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners. J Appl Toxicol 2001;21:211-9.
28. Kodavanti PRS, Tilson HA. Neurochemical effects of environmental chemicals. Ann N Y Acad Sci 2000;919:97-105.
29. Agostoni C, Trojan S, Bellu R, Riva E, Giovannini M. Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long-chain polyunsaturated fatty acids. Pediatr Res 1995;38:262-6.
30. Willatts P, Forsyth JS, DiModugno MK, Varma S, Colvin M. Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age. Lancet 1998;352: 688-91.
31. Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996; 335:783-9.
32. Gladen BC, Rogan WJ. Effects of perinatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J Pediatr 1991;119:58-63.