Pharmacokinetics of Intranasal versus Subcutaneous Insulin in the Mouse

ACS Chemical Neuroscience

Volumn 9, Issue 4, 2018, Pages 809-816

  Nedelcovych, Michael T ^a,b   Gadiano, Alexandra J ^a   Wu, Ying ^a   Manning, Arena A ^a,b   Thomas, Ajit G ^a   Khuder, Saja S ^b,g   Yoo, Seung Wan ^b   Xu, Jiadi ^h   McArthur, Justin C ^b   Haughey, Norman J ^b,e   Volsky, David J ^h   Rais, Rana ^a,b   Slusher, Barbara S ^a,b,c,d,e,f  

^a Departments of Neurology   (United States)

^b Departments of Medicine   (United States)

^c Departments of Oncology   (United States)

^d Departments of Psychiatry   (United States)

^e Departments of Neuroscience   (United States)

^f Departments of Neuroimmunology   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

energy metabolism; glucose; Insulin; intranasal; neurocognitive impairment; pharmacokinetics

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; HYPOGLYCEMIA; INSULIN CLEARANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BLOOD; BLOOD BRAIN BARRIER; BRAIN; CEREBROSPINAL FLUID; COGNITIVE DEFECT; INTRANASAL DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY;

ADMINISTRATION, INTRANASAL; ANIMALS; BLOOD GLUCOSE; BLOOD-BRAIN BARRIER; BRAIN; COGNITION DISORDERS; ENERGY METABOLISM; INSULIN; MALE; MICE;

EID: 85045553473     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.7b00434     Document Type: Article

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