Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Guo, Zhangyu ^a   Chen, Yanxing ^a   Mao, Yan Fang ^a   Zheng, Tingting ^a   Jiang, Yasi ^a   Yan, Yaping ^a   Yin, Xinzhen ^a   Zhang, Baorong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DOUBLECORTIN PROTEIN; GLYCOGEN SYNTHASE KINASE 3; INSULIN; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE; PHOSPHOPROTEIN PHOSPHATASE; STREPTOZOCIN; TAU PROTEIN; TAU-PROTEIN KINASE;

ALZHEIMER DISEASE; ANIMAL; BRAIN; COGNITIVE DEFECT; COMPLICATION; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; INFLAMMATION; INTRANASAL DRUG ADMINISTRATION; MALE; MAZE TEST; MEMORY DISORDER; METABOLISM; MICROGLIA; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SYNAPSE;

ADMINISTRATION, INTRANASAL; ALZHEIMER DISEASE; ANIMALS; BIOMARKERS; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GLYCOGEN SYNTHASE KINASE 3; INFLAMMATION; INSULIN; MALE; MAZE LEARNING; MEMORY DISORDERS; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; NEUROPEPTIDES; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STREPTOZOCIN; SYNAPSES; TAU PROTEINS;

EID: 85017165914     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep45971     Document Type: Article

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