Intranasal delivery of insulin via the olfactory nerve pathway

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 12, 2012, Pages 1709-1714

  Renner, Dan B ^a   Svitak, Aleta L ^a   Gallus, Nathan J ^a   Ericson, Marna E ^a   Frey II, William H ^a   Hanson, Leah R ^a  

^a REGIONS HOSPITAL   (United States)

Author keywords

Alzheimer's disease; insulin; intranasal; olfactory bulbs; olfactory nerve pathway

Indexed keywords

ISOPHANE INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG DISTRIBUTION; ELECTRON MICROSCOPY; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; MALE; MOUSE; NONHUMAN; NOSE MUCOSA; OLFACTORY BULB; OLFACTORY EPITHELIUM; OLFACTORY NERVE; OLFACTORY NERVOUS SYSTEM;

ADMINISTRATION, INTRANASAL; ANIMALS; CENTRAL NERVOUS SYSTEM; ETHMOID BONE; INSULIN; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY; NASAL MUCOSA; OLFACTORY BULB; OLFACTORY NERVE; OLFACTORY PATHWAYS;

EID: 84869089454     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01555.x     Document Type: Article

References (25)

1. Dhuria SV, et al,. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 2010; 99: 1654-1673.
2. Frey WHI,. Method of Administering Neurologic Agents to the Brain. 1997. US Patent No.: 5,624,898.
3. Frey WHI,. Method for Administering Insulin to the Brain. 2001. US Patent No.: 6,313,093,B1.
4. Frey WHI,. Neurologic Agents for Nasal Administration to the Brain. 1991. WIPO Patent No.: WO1991007947.
5. Kristensson K, et al,. Uptake of exogenous proteins in mouse olfactory cells. Acta Neuropathol 1971; 19: 145-154.
6. Jansson B, et al,. Visualization of in vivo olfactory uptake and transfer using fluorescein dextran. J Drug Target 2002; 10: 379-386.
7. Westin U, et al,. Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents. Eur J Pharm Sci 2005; 24: 565-573.
8. Larsson P, et al,. Intranasal instillation of aflatoxin B(1) in rats: bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb. Toxicol Sci 2000; 55: 383-391.
9. Broadwell RD, et al,. Endocytic and exocytic pathways of the neuronal secretory process and trans-synaptic transfer of wheat germ agglutinin- horseradish peroxidase in vivo. J Comp Neurol 1985; 242: 632-650.
10. Thorne RG, et al,. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res 1995; 692: 278-282.
11. Thorne RG, et al,. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127: 481-496.
12. Baker H, et al,. Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat. Exp Brain Res 1986; 63: 461-473.
13. Banks WA,. The source of cerebral insulin. Eur J Pharmacol 2004; 490: 5-12.
14. Francis GJ, et al,. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008; 131: 3311-3334.
15. Craft S, et al,. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol 2012; 69: 29-38.
16. Li Y, et al,. Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres. Glia 2005; 52: 245-251.
17. Field P, et al,. Ensheathment of the olfactory nerves in the adult rat. J Neurocytol 2003; 32: 317-324.
18. Shemesh E, et al,. Effect of intranasal insulin on cognitive function: a systematic review. J Clin Endocrinol Metab 2012; 97: 366-376.
19. Havrankova J, et al,. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 1978; 272: 827-829.
20. Unger JW, et al,. Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog Neurobiol 1991; 36: 343-362.
21. Pan W, et al,. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice. J Mol Neurosci 2011; 43: 478-484.
22. Harada S, et al,. Mechanisms of nuclear translocation of insulin. Cell Biochem Biophys 1999; 31: 307-319.
23. Shah N, et al,. Electron microscopic visualization of insulin translocation into the cytoplasm and nuclei of intact H35 hepatoma cells using covalently linked Nanogold-insulin. Endocrinology 1995; 136: 2825-2835.
24. Smith RM, et al,. Ultrastructural evidence for the accumulation of insulin in nuclei of intact 3T3-L1 adipocytes by an insulin-receptor mediated process. Proc Natl Acad Sci U S A 1987; 84: 459-463.
25. Nores JM, et al,. Olfactory disorders in Alzheimer's disease and in Parkinson's disease. Review of the literature. Ann Med Interne (Paris) 2000; 151: 97-106.