Brain delivery of insulin boosted by intranasal coadministration with cell-penetrating peptides

Journal of Controlled Release

Volumn 197, Issue , 2015, Pages 105-110

  Kamei, Noriyasu ^a   Takeda Morishita, Mariko ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Brain delivery; Cell penetrating peptide; Insulin; Intranasal route; Penetratin

Indexed keywords

CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; INSULIN; MACROMOLECULES; PEPTIDES; RESPIRATORY MECHANICS; TARGETED DRUG DELIVERY;

ALTERNATIVE ROUTES; BIOPHARMACEUTICALS; BLOOD-BRAIN BARRIER; BRAIN DELIVERY; CELL-PENETRATING PEPTIDE; CENTRAL NERVOUS SYSTEMS; INTRANASAL; PENETRATIN;

BRAIN;

CELL PENETRATING PEPTIDE; PENETRATIN; RECOMBINANT HUMAN INSULIN; CARRIER PROTEIN; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN STEM; CEREBELLUM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MOUSE; NERVE CELL; NERVE FIBER TRANSPORT; NONHUMAN; NOSE CAVITY; OLFACTORY BULB; SCANNING ELECTRON MICROSCOPY; ANIMAL; INTRANASAL DRUG ADMINISTRATION; METABOLISM;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; CARRIER PROTEINS; CELL-PENETRATING PEPTIDES; DRUG DELIVERY SYSTEMS; INSULIN; MALE; MICE;

EID: 84911499289     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.11.004     Document Type: Article

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