Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

Cell

Volumn 173, Issue 4, 2018, Pages 879-893.e13

  Kim, Charissa ^a   Gao, Ruli ^a   Sei, Emi ^a   Brandt, Rachel ^a   Hartman, Johan ^b   Hatschek, Thomas ^b   Crosetto, Nicola ^b   Foukakis, Theodoros ^b   Navin, Nicholas E ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

breast cancer genomics; cancer aneuploidy; chemotherapy; copy number evolution; intratumor heterogeneity; single cell sequencing; therapy resistance; triple negative breast cancer; tumor evolution

Indexed keywords

DNA; RNA; ANTINEOPLASTIC AGENT; TRANSCRIPTOME;

ARTICLE; CANCER RESISTANCE; CLONAL EVOLUTION; CONTROLLED STUDY; DNA SEQUENCE; EXOME; GENE DOSAGE; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; HUMAN CELL; NEOADJUVANT CHEMOTHERAPY; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; RNA SEQUENCE; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; TRIPLE NEGATIVE BREAST CANCER; CASE CONTROL STUDY; CLUSTER ANALYSIS; COPY NUMBER VARIATION; DRUG RESISTANCE; FEMALE; GENE FREQUENCY; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MORTALITY; NEOADJUVANT THERAPY; PATHOLOGY; SURVIVAL ANALYSIS;

ANTINEOPLASTIC AGENTS; CASE-CONTROL STUDIES; CLUSTER ANALYSIS; DNA COPY NUMBER VARIATIONS; DRUG RESISTANCE, NEOPLASM; EXOME; FEMALE; GENE FREQUENCY; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; NEOADJUVANT THERAPY; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; SURVIVAL ANALYSIS; TRANSCRIPTOME; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 85045475727     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.03.041     Document Type: Article

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