Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

Neurobiology of Disease

Volumn 115, Issue , 2018, Pages 101-114

  De Miranda, Briana R ^a   Rocha, Emily M ^a   Bai, Qing ^a   El Ayadi, Amina ^a   Hinkle, David ^a   Burton, Edward A ^a,b   Timothy Greenamyre, J ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Astrocyte; Chaperone mediated autophagy; DJ 1; Gene therapy; Neuroinflammation; Oxidative stress; Parkinson's disease; Rotenone

Indexed keywords

ALPHA SYNUCLEIN; LENTIVIRUS VECTOR; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; PROTEIN DEGLYCASE DJ-1; ROTENONE; INSECTICIDE; PARK7 PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; IMMUNOREACTIVITY; IN VIVO STUDY; LEWIS RAT; MALE; MICROGLIA; MIDDLE AGED; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RAT MODEL; SUBSTANTIA NIGRA; TRANSGENE; TROPISM; VIRAL GENE DELIVERY SYSTEM; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PARKINSONISM;

ANIMALS; ASTROCYTES; GENE EXPRESSION; HUMANS; INSECTICIDES; MALE; PARKINSONIAN DISORDERS; PROTEIN DEGLYCASE DJ-1; RATS; RATS, INBRED LEW; ROTENONE;

EID: 85045275467     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2018.04.008     Document Type: Article

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