Overexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy

Neuroscience Letters

Volumn 603, Issue , 2015, Pages 71-76

  Jaramillo Gómez, Jenny ^a   Niño, Andrea ^a   Arboleda, Humberto ^a   Arboleda, Gonzalo ^a  

^a UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

Autophagy; C2 ceramide; DJ 1; MTOR; Parkinson's disease; PI3K AKT

Indexed keywords

C2 CERAMIDE; CERAMIDE DERIVATIVE; DJ 1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SERINE; UNCLASSIFIED DRUG; DJ-1 PROTEIN, MOUSE; N-ACETYLSPHINGOSINE; ONCOPROTEIN; PEROXIREDOXIN; SPHINGOSINE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CATECHOLAMINE NERVE CELL; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; GENE OVEREXPRESSION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; METABOLISM; NERVE CELL;

ANIMALS; AUTOPHAGY; CELL LINE; CELL SURVIVAL; MICE; NEURONS; ONCOGENE PROTEINS; PEROXIREDOXINS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; SPHINGOSINE; TOR SERINE-THREONINE KINASES;

EID: 84938778206     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.07.032     Document Type: Article

References (30)

1. Savitt J.M., Dawson V.L., Dawson T.M. Diagnosis and treatment of Parkinson disease: molecules to medicine. J. Clin. Invest. 2006, 116:1744-1754.
2. Wood-Kaczmar A., Gandhi S., Wood N.W. Understanding the molecular causes of Parkinson's disease. Trends Mol. Med. 2006, 12:521-528.
3. Bonifati V., Rizzu P., Squitieri F., Krieger E., Vanacore N., van Swieten J.C., Brice A., van Duijn C.M., Oostra B., Meco G., Heutink P. DJ-1(PARK7), a novel gene for autosomal recessive, early onset parkinsonism. Neurol. Sci. 2003, 24:159-160.
4. Mitsumoto A., Nakagawa Y. DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic. Res. 2001, 35:885-893.
5. Yokota T., Sugawara K., Ito K., Takahashi R., Ariga H., Mizusawa H. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 2003, 312:1342-1348.
6. Rousseaux M.W., Marcogliese P.C., Qu D., Hewitt S.J., Seang S., Kim R.H., Slack R.S., Schlossmacher M.G., Lagace D.C., Mak T.W., Park D.S. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:15918-15923.
7. Gao H., Yang W., Qi Z., Lu L., Duan C., Zhao C., Yang H. DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. J. Mol. Biol 2012, 423:232-248.
8. Krebiehl G., Ruckerbauer S., Burbulla L.F., Kieper N., Maurer B., Waak J., Wolburg H., Gizatullina Z., Gellerich F.N., Woitalla D., Riess O., Kahle P.J., Proikas-Cezanne T., Kruger R. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. One 2010, 5:e9367.
9. Arboleda G., Waters C., Gibson R. Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. Neurosci. Lett. 2007, 421:245-249.
10. Scarlatti F., Bauvy C., Ventruti A., Sala G., Cluzeaud F., Vandewalle A., Ghidoni R., Codogno P. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 2004, 279:18384-18391.
11. Arboleda G., Waters C., Gibson R.M. Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. J. Mol. Neurosci. 2005, 27:65-77.
12. France-Lanord V., Brugg B., Michel P.P., Agid Y., Ruberg M. Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J. Neurochem. 1997, 69:1612-1621.
13. Arboleda G., Cardenas Y., Rodriguez Y., Morales L.C., Matheus L., Arboleda H. Differential regulation of AKT, MAPK and GSK3beta during C2-ceramide-induced neuronal death. Neurotoxicology 2010, 31:687-693.
14. Darios F., Corti O., Lucking C.B., Hampe C., Muriel M.P., Abbas N., Gu W.J., Hirsch E.C., Rooney T., Ruberg M., Brice A. Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum. Mol. Genet. 2003, 12:517-526.
15. da Costa C.A., Ancolio K., Checler F. Wild-type but not Parkinson's disease-related ala-53 -> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli. J. Biol. Chem. 2000, 275:24065-24069.
16. Sanchez-Mora R.M., Arboleda H., Arboleda G. PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway. J. Mol. Neurosci. 2012, 47:582-594.
17. Vazquez F., Ramaswamy S., Nakamura N., Sellers W.R. Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell Biol. 2000, 20:5010-5018.
18. Choi J., Sullards M.C., Olzmann J.A., Rees H.D., Weintraub S.T., Bostwick D.E., Gearing M., Levey A.I., Chin L.S., Li L. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J. Biol. Chem. 2006, 281:10816-10824.
19. Kotaria N., Hinz U., Zechel S., von Bohlen Und H.O. Localization of DJ-1 protein in the murine brain. Cell Tissue Res. 2005, 322:503-507.
20. Irrcher I., Aleyasin H., Seifert E.L., Hewitt S.J., Chhabra S., Phillips M., Lutz A.K., Rousseaux M.W., Bevilacqua L., Jahani-Asl A., Callaghan S., MacLaurin J.G., Winklhofer K.F., Rizzu P., Rippstein P., Kim R.H., Chen C.X., Fon E.A., Slack R.S., Harper M.E., McBride H.M., Mak T.W., Park D.S. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum. Mol. Genet 2010, 19:3734-3746.
21. Canet-Aviles R.M., Wilson M.A., Miller D.W., Ahmad R., McLendon C., Bandyopadhyay S., Baptista M.J., Ringe D., Petsko G.A., Cookson M.R. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:9103-9108.
22. Timmons S., Coakley M.F., Moloney A.M., O' Neill C. Akt signal transduction dysfunction in Parkinson's disease. Neurosci. Lett. 2009, 467:30-35.
23. Sofic E., Denisova N., Youdim K., Vatrenjak-Velagic, De F.C., Mehmedagic A., Causevic A., Cao G., Joseph J.A., Prior R.L. Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and sphingomyelinase activity in pheochromocytoma PC12 cells: potential relevance to age-related diseases. J. Neural. Transm. 2001, 108:541-557.
24. Arboleda G., Huang T.J., Waters C., Verkhratsky A., Fernyhough P., Gibson R.M. Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. Eur. J. Neurosci. 2007, 25:3030-3038.
25. Guenther G.G., Peralta E.R., Rosales K.R., Wong S.Y., Siskind L.J., Edinger A.L. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:17402-17407.
26. Pattingre S., Bauvy C., Carpentier S., Levade T., Levine B., Codogno P. Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J. Biol. Chem. 2009, 284:2719-2728.
27. McCoy,M K., Cookson M.R. DJ-1 regulation of mitochondrial function and autophagy through oxidative stress. Autophagy 2011, 7:531-532.
28. Aleyasin H., Rousseaux M.W., Marcogliese P.C., Hewitt S.J., Irrcher I., Joselin A.P., Parsanejad M., Kim R.H., Rizzu P., Callaghan S.M., Slack R.S., Mak T.W., Park D.S. DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:3186-3191.
29. Kim R.H., Peters M., Jang Y., Shi W., Pintilie M., Fletcher G.C., DeLuca C., Liepa J., Zhou L., Snow B., Binari R.C., Manoukian A.S., Bray M.R., Liu F.F., Tsao M.S., Mak T.W. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 2005, 7:263-273.
30. Goldberg M.S., Pisani A., Haburcak M., Vortherms T.A., Kitada T., Costa C., Tong Y., Martella G., Tscherter A., Martins A., Bernardi G., Roth B.L., Pothos E.N., Calabresi P., Shen J. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 2005, 45:489-496.