Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner

Nature Microbiology

Volumn 3, Issue 5, 2018, Pages 611-621

  Gopinath, Smita ^a,b   Kim, Myoungjoo V ^b   Rakib, Tasfia ^b   Wong, Patrick W ^b   Van Zandt, Michael ^c   Barry, Natasha A ^d   Kaisho, Tsuneyasu ^e   Goodman, Andrew L ^a,d   Iwasaki, Akiko ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c New England Discovery Partners   (United States)

^d YALE UNIVERSITY   (United States)

^e WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPICILLIN; BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1 RECEPTOR; METRONIDAZOLE; NEOMYCIN; TOLL LIKE RECEPTOR 3; VANCOMYCIN; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; TLR3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENE; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLUENZA; INFLUENZA A VIRUS; INTERFERON STIMULATED GENE; MALE; MICROARRAY ANALYSIS; MICROFLORA; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; VAGINA MUCOSA; VIRUS INFECTION; VIRUS REPLICATION; ZIKA VIRUS; ANIMAL; DISEASE MODEL; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PROCEDURES; SIMPLEXVIRUS; TOPICAL DRUG ADMINISTRATION; VIROLOGY;

ADMINISTRATION, TOPICAL; AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GERM-FREE LIFE; HUMANS; INFLUENZA A VIRUS; MICE; MICROBIOTA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIMPLEXVIRUS; TOLL-LIKE RECEPTOR 3; TRANSCRIPTION FACTORS; VIRUS DISEASES; VIRUS REPLICATION; ZIKA VIRUS;

EID: 85045106900     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/s41564-018-0138-2     Document Type: Article

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