Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

Cell Reports

Volumn 18, Issue 3, 2017, Pages 804-815

  Rausch, Keiko ^a   Hackett, Brent A ^a   Weinbren, Nathan L ^a   Reeder, Sophia M ^a   Sadovsky, Yoel ^b,c   Hunter, Christopher A ^a   Schultz, David C ^a   Coyne, Carolyn B ^b,c   Cherry, Sara ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

antivirals; arbovirus; drugs; entry; flavivirus; repurposing; therapeutics

Indexed keywords

2 AMINO N [4 [5 (2 PHENANTHRENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]PHENYL]ACETAMIDE; ACICLOVIR; ALBENDAZOLE; ANTIVIRUS AGENT; ARECOLINE; AXL PROTEIN; CABAZITAXEL; CABOZANTINIB; DIOSCIN; EMETINE; FLUBENDAZOLE; FORETINIB; GEMCITABINE; GLESATINIB; GSK 2656157; KI 8751; MEMBRANE PROTEIN; METHOTREXATE; MYCOPHENOLIC ACID; N [4 [(2 AMINO 3 CHLORO 4 PYRIDINYL)OXY] 3 FLUOROPHENYL] 4 ETHOXY 1 (4 FLUOROPHENYL) 2(1H) OXONICOTINAMIDE; NANCHANGMYCIN; NAVITOCLAX; NUCLEOSIDE ANALOG; OXIBENDAZOLE; PROTEIN TYROSINE KINASE INHIBITOR; REBASTINIB; RGFP 966; TENOVIN 1; TIOGUANINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ETHER DERIVATIVE; NUCLEOSIDE; SPIRO COMPOUND;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHIKUNGUNYA VIRUS; CONTROLLED STUDY; DENGUE VIRUS; DRUG APPROVAL; DRUG IDENTIFICATION; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN CELL; MICROSCOPY; NONHUMAN; PLACENTA; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIRUS ENTRY; VIRUS INFECTION; VIRUS STRAIN; WEST NILE VIRUS; ZIKA VIRUS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; MOLECULAR LIBRARY; PHARMACOLOGY; PHYSIOLOGY; TROPHOBLAST; VIROLOGY;

ANTIVIRAL AGENTS; CELLS, CULTURED; CHIKUNGUNYA VIRUS; DENGUE VIRUS; ENDOTHELIAL CELLS; ETHERS; HUMANS; NUCLEOSIDES; SMALL MOLECULE LIBRARIES; SPIRO COMPOUNDS; TROPHOBLASTS; VIRUS INTERNALIZATION; WEST NILE VIRUS; ZIKA VIRUS;

EID: 85009754876     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.12.068     Document Type: Article

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