Evidence that antibiotics bind to human mitochondrial ribosomal RNA has implications for aminoglycoside toxicity

Journal of Biological Chemistry

Volumn 290, Issue 31, 2015, Pages 19273-19286

  Hong, Seoyeon ^a   Harris, Kimberly A ^a   Fanning, Kathryn D ^a   Sarachan, Kathryn L ^a   Frohlich, Kyla M ^a   Agris, Paul F ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOSYNTHESIS; DISSOCIATION; ESCHERICHIA COLI; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RNA; STABILITY; TOXICITY;

AMINOGLYCOSIDE ANTIBIOTICS; BACTERIAL INFECTIONS; BACTERIAL RIBOSOMES; CONFORMATIONAL CHANGE; CONFORMATIONAL STABILITIES; DISSOCIATION CONSTANT; STRUCTURAL STABILITIES; TWO-DIMENSIONAL NMR;

ANTIBIOTICS;

GENTAMICIN; KANAMYCIN A; RIBOSOME RNA; ANTIINFECTIVE AGENT; BACTERIAL RNA; KANAMYCIN; RNA; RNA, MITOCHONDRIAL;

ADVERSE DRUG REACTION; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING; DRUG STRUCTURE; INTERACTIONS WITH RNA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RNA CONFORMATION; RNA STABILITY; RNA STRUCTURE; THERMODYNAMICS; THERMOSTABILITY; CHEMISTRY; ESCHERICHIA COLI; HUMAN; INVERTED REPEAT;

ANTI-BACTERIAL AGENTS; ESCHERICHIA COLI; GENTAMICINS; HUMANS; INVERTED REPEAT SEQUENCES; KANAMYCIN; RNA; RNA STABILITY; RNA, BACTERIAL; RNA, RIBOSOMAL;

EID: 84940705095     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.655092     Document Type: Article

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