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Volumn 34, Issue 10, 2013, Pages 487-494

Generating protective immunity against genital herpes

Author keywords

Antibodies; Cell migration; Female genital tract; Memory T cells; Protective immunity; Vaccines

Indexed keywords

GLYCOPROTEIN B; GLYCOPROTEIN D;

EID: 84884815297     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2013.08.001     Document Type: Review
Times cited : (44)

References (78)
  • 1
    • 54249103516 scopus 로고    scopus 로고
    • An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection
    • Looker K.J., et al. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull. World Health Organ. 2008, 86:737-816.
    • (2008) Bull. World Health Organ. , vol.86 , pp. 737-816
    • Looker, K.J.1
  • 2
    • 77951244078 scopus 로고    scopus 로고
    • Seroprevalence of herpes simplex virus type 2 among persons aged 14-49 years - United States, 2005-2008
    • Centers for Disease Control
    • Centers for Disease Control Seroprevalence of herpes simplex virus type 2 among persons aged 14-49 years - United States, 2005-2008. Morb. Mortal. Wkly. Rep. 2008, 59:456-459.
    • (2008) Morb. Mortal. Wkly. Rep. , vol.59 , pp. 456-459
  • 3
    • 84857233459 scopus 로고    scopus 로고
    • Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
    • Johnston C., et al. Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials. Lancet 2012, 379:641-647.
    • (2012) Lancet , vol.379 , pp. 641-647
    • Johnston, C.1
  • 4
    • 84055193947 scopus 로고    scopus 로고
    • HSV-2: in pursuit of a vaccine
    • Johnston C., et al. HSV-2: in pursuit of a vaccine. J. Clin. Invest. 2011, 121:4600-4609.
    • (2011) J. Clin. Invest. , vol.121 , pp. 4600-4609
    • Johnston, C.1
  • 5
    • 84875867534 scopus 로고    scopus 로고
    • HSV-2 vaccine: current state and insights into development of a vaccine that targets genital mucosal protection
    • Roth K., et al. HSV-2 vaccine: current state and insights into development of a vaccine that targets genital mucosal protection. Microb. Pathog. 2013, 58:45-54.
    • (2013) Microb. Pathog. , vol.58 , pp. 45-54
    • Roth, K.1
  • 6
    • 84857369888 scopus 로고    scopus 로고
    • Viral and cellular contributions to herpes simplex virus entry into the cell
    • Campadelli-Fiume G., et al. Viral and cellular contributions to herpes simplex virus entry into the cell. Curr. Opin. Virol. 2012, 2:28-36.
    • (2012) Curr. Opin. Virol. , vol.2 , pp. 28-36
    • Campadelli-Fiume, G.1
  • 7
    • 39149132854 scopus 로고    scopus 로고
    • Chromatin control of herpes simplex virus lytic and latent infection
    • Knipe D.M., Cliffe A. Chromatin control of herpes simplex virus lytic and latent infection. Nat. Rev. Microbiol. 2008, 6:211-221.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 211-221
    • Knipe, D.M.1    Cliffe, A.2
  • 8
    • 84867649395 scopus 로고    scopus 로고
    • Herpesvirus transport to the nervous system and back again
    • Smith G. Herpesvirus transport to the nervous system and back again. Annu. Rev. Microbiol. 2012, 66:153-176.
    • (2012) Annu. Rev. Microbiol. , vol.66 , pp. 153-176
    • Smith, G.1
  • 9
    • 84869501436 scopus 로고    scopus 로고
    • A cultured affair: HSV latency and reactivation in neurons
    • Wilson A.C., Mohr I. A cultured affair: HSV latency and reactivation in neurons. Trends Microbiol. 2012, 20:604-611.
    • (2012) Trends Microbiol. , vol.20 , pp. 604-611
    • Wilson, A.C.1    Mohr, I.2
  • 10
    • 39649109256 scopus 로고    scopus 로고
    • Herpes simplex: insights on pathogenesis and possible vaccines
    • Koelle D.M., Corey L. Herpes simplex: insights on pathogenesis and possible vaccines. Annu. Rev. Med. 2008, 59:381-395.
    • (2008) Annu. Rev. Med. , vol.59 , pp. 381-395
    • Koelle, D.M.1    Corey, L.2
  • 11
    • 84879050128 scopus 로고    scopus 로고
    • Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
    • Schiffer J.T., et al. Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract. eLife 2013, 2:e00288.
    • (2013) eLife , vol.2
    • Schiffer, J.T.1
  • 12
    • 0034704798 scopus 로고    scopus 로고
    • Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    • Wald A., et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N. Engl. J. Med. 2000, 342:844-950.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 844-950
    • Wald, A.1
  • 13
    • 79953848750 scopus 로고    scopus 로고
    • Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection
    • Tronstein E., et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA 2011, 305:1441-1449.
    • (2011) JAMA , vol.305 , pp. 1441-1449
    • Tronstein, E.1
  • 14
    • 77953919549 scopus 로고    scopus 로고
    • Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model
    • Schiffer J.T., et al. Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Sci. Transl. Med. 2009, 1:7ra16.
    • (2009) Sci. Transl. Med. , vol.1
    • Schiffer, J.T.1
  • 15
    • 79251477166 scopus 로고    scopus 로고
    • Recognition of herpesviruses by the innate immune system
    • Paludan S.R., et al. Recognition of herpesviruses by the innate immune system. Nat. Rev. Immunol. 2011, 11:143-154.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 143-154
    • Paludan, S.R.1
  • 16
    • 84873810684 scopus 로고    scopus 로고
    • The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway
    • Cai M., et al. The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. PLoS ONE 2013, 8:e54586.
    • (2013) PLoS ONE , vol.8
    • Cai, M.1
  • 17
    • 77958140656 scopus 로고    scopus 로고
    • IFI16 is an innate immune sensor for intracellular DNA
    • Unterholzner L., et al. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 2010, 11:997-1004.
    • (2010) Nat. Immunol. , vol.11 , pp. 997-1004
    • Unterholzner, L.1
  • 18
    • 84868095535 scopus 로고    scopus 로고
    • Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
    • Orzalli M.H., et al. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E3008-E3017.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109
    • Orzalli, M.H.1
  • 19
    • 84862976171 scopus 로고    scopus 로고
    • Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
    • Li T., et al. Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:10558-10563.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 10558-10563
    • Li, T.1
  • 20
    • 84863116708 scopus 로고    scopus 로고
    • Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16
    • Conrady C.D., et al. Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16. Mucosal Immunol. 2012, 5:173-183.
    • (2012) Mucosal Immunol. , vol.5 , pp. 173-183
    • Conrady, C.D.1
  • 21
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu Y-H., et al. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009, 138:576-591.
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.-H.1
  • 22
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • Sun L., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013, 339:786-791.
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1
  • 23
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu J., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 2013, 339:826-830.
    • (2013) Science , vol.339 , pp. 826-830
    • Wu, J.1
  • 24
    • 77951269392 scopus 로고    scopus 로고
    • The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    • Rathinam V.A.K., et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 2010, 11:395-402.
    • (2010) Nat. Immunol. , vol.11 , pp. 395-402
    • Rathinam, V.A.K.1
  • 25
    • 84876334378 scopus 로고    scopus 로고
    • Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes
    • Johnson K.E., et al. Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes. J. Virol. 2013, 87:5005-5018.
    • (2013) J. Virol. , vol.87 , pp. 5005-5018
    • Johnson, K.E.1
  • 26
    • 84864144593 scopus 로고    scopus 로고
    • Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
    • Holm C.K., et al. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nat. Immunol. 2012, 13:737-743.
    • (2012) Nat. Immunol. , vol.13 , pp. 737-743
    • Holm, C.K.1
  • 27
    • 9244237556 scopus 로고    scopus 로고
    • Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
    • Sato A., et al. Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:16274-21629.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 16274-21629
    • Sato, A.1
  • 28
    • 34247877512 scopus 로고    scopus 로고
    • Mucosal dendritic cells
    • Iwasaki A. Mucosal dendritic cells. Annu. Rev. Immunol. 2007, 25:381-418.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 381-418
    • Iwasaki, A.1
  • 29
    • 63049125497 scopus 로고    scopus 로고
    • Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
    • Lee H.K., et al. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. J. Exp. Med. 2009, 206:359-370.
    • (2009) J. Exp. Med. , vol.206 , pp. 359-370
    • Lee, H.K.1
  • 30
    • 70449732252 scopus 로고    scopus 로고
    • Dendritic cell subsets in primary and secondary T cell responses at body surfaces
    • Heath W.R., Carbone F.R. Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat. Immunol. 2009, 10:1237-1244.
    • (2009) Nat. Immunol. , vol.10 , pp. 1237-1244
    • Heath, W.R.1    Carbone, F.R.2
  • 31
    • 70849099812 scopus 로고    scopus 로고
    • + T-cell help
    • + T-cell help. Nature 2009, 462:510-513.
    • (2009) Nature , vol.462 , pp. 510-513
    • Nakanishi, Y.1
  • 32
    • 45849153869 scopus 로고    scopus 로고
    • Coordination of early protective immunity to viral infection by regulatory T cells
    • Lund J.M., et al. Coordination of early protective immunity to viral infection by regulatory T cells. Science 2008, 320:1220-1224.
    • (2008) Science , vol.320 , pp. 1220-1224
    • Lund, J.M.1
  • 33
    • 84875208257 scopus 로고    scopus 로고
    • Rapid host immune response and viral dynamics in herpes simplex virus-2 infection
    • Schiffer J.T., Corey L. Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. Nat. Med. 2013, 19:280-288.
    • (2013) Nat. Med. , vol.19 , pp. 280-288
    • Schiffer, J.T.1    Corey, L.2
  • 34
    • 84878130297 scopus 로고    scopus 로고
    • + skin-resident T cells in human herpes virus infection
    • + skin-resident T cells in human herpes virus infection. Nature 2013, 497:494-497.
    • (2013) Nature , vol.497 , pp. 494-497
    • Zhu, J.1
  • 35
    • 78650499757 scopus 로고    scopus 로고
    • Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    • Schiffer J.T., et al. Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:18973-18978.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 18973-18978
    • Schiffer, J.T.1
  • 36
    • 33947424353 scopus 로고    scopus 로고
    • + T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    • + T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J. Exp. Med. 2007, 204:595-603.
    • (2007) J. Exp. Med. , vol.204 , pp. 595-603
    • Zhu, J.1
  • 37
    • 78349271168 scopus 로고    scopus 로고
    • Toll-like receptor expression in the peripheral nerve
    • Goethals S., et al. Toll-like receptor expression in the peripheral nerve. Glia 2010, 58:1701-1709.
    • (2010) Glia , vol.58 , pp. 1701-1709
    • Goethals, S.1
  • 38
    • 82955167855 scopus 로고    scopus 로고
    • Inborn errors of anti-viral interferon immunity in humans
    • Sancho-Shimizu V., et al. Inborn errors of anti-viral interferon immunity in humans. Curr. Opin. Virol. 2011, 1:487-496.
    • (2011) Curr. Opin. Virol. , vol.1 , pp. 487-496
    • Sancho-Shimizu, V.1
  • 39
    • 84859716889 scopus 로고    scopus 로고
    • TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice
    • Reinert L.S., et al. TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice. J. Clin. Invest. 2012, 122:1368-1376.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1368-1376
    • Reinert, L.S.1
  • 40
    • 84870292016 scopus 로고    scopus 로고
    • Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells
    • Lafaille F.G., et al. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature 2012, 491:769-773.
    • (2012) Nature , vol.491 , pp. 769-773
    • Lafaille, F.G.1
  • 41
    • 76249112828 scopus 로고    scopus 로고
    • Autophagy protects against Sindbis virus infection of the central nervous system
    • Orvedahl A., et al. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 2010, 7:115-127.
    • (2010) Cell Host Microbe , vol.7 , pp. 115-127
    • Orvedahl, A.1
  • 42
    • 84866353521 scopus 로고    scopus 로고
    • A neuron-specific role for autophagy in antiviral defense against herpes simplex virus
    • Yordy B., et al. A neuron-specific role for autophagy in antiviral defense against herpes simplex virus. Cell Host Microbe 2012, 12:334-345.
    • (2012) Cell Host Microbe , vol.12 , pp. 334-345
    • Yordy, B.1
  • 43
    • 0037728671 scopus 로고    scopus 로고
    • + T cells are selectively activated and retained in latently infected sensory ganglia
    • + T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 2003, 18:593-603.
    • (2003) Immunity , vol.18 , pp. 593-603
    • Khanna, K.M.1
  • 44
    • 38149001476 scopus 로고    scopus 로고
    • Dendritic cell-induced memory T cell activation in nonlymphoid tissues
    • Wakim L.M., et al. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science 2008, 319:198-202.
    • (2008) Science , vol.319 , pp. 198-202
    • Wakim, L.M.1
  • 45
    • 84869501348 scopus 로고    scopus 로고
    • + T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation
    • + T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation. J. Neurovirol. 2011, 17:528-534.
    • (2011) J. Neurovirol. , vol.17 , pp. 528-534
    • St Leger, A.1
  • 46
    • 53749095611 scopus 로고    scopus 로고
    • + T cell inhibition of HSV-1 reactivation from neuronal latency
    • + T cell inhibition of HSV-1 reactivation from neuronal latency. Science 2008, 322:268-271.
    • (2008) Science , vol.322 , pp. 268-271
    • Knickelbein, J.E.1
  • 47
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry E.J. T cell exhaustion. Nat. Immunol. 2011, 12:492-499.
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 48
    • 84857473338 scopus 로고    scopus 로고
    • Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection
    • Mackay L.K., et al. Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J. Immunol. 2012, 188:2173-2178.
    • (2012) J. Immunol. , vol.188 , pp. 2173-2178
    • Mackay, L.K.1
  • 49
    • 80052279263 scopus 로고    scopus 로고
    • + T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism
    • + T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. J. Virol. 2011, 85:9127-9138.
    • (2011) J. Virol. , vol.85 , pp. 9127-9138
    • Chentoufi, A.A.1
  • 50
    • 59649121568 scopus 로고    scopus 로고
    • Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus
    • Iijima N., et al. Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J. Exp. Med. 2008, 205:3041-3052.
    • (2008) J. Exp. Med. , vol.205 , pp. 3041-3052
    • Iijima, N.1
  • 51
    • 80052555420 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Nature 2011, 477:216-219.
    • (2011) Nature , vol.477 , pp. 216-219
    • Gebhardt, T.1
  • 52
    • 43749114944 scopus 로고    scopus 로고
    • Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells
    • Morrison L.A. Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells. Virology 2008, 376:205-210.
    • (2008) Virology , vol.376 , pp. 205-210
    • Morrison, L.A.1
  • 53
    • 73149123781 scopus 로고    scopus 로고
    • Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection
    • Johnson A.J., et al. Herpes simplex virus (HSV)-specific T cells activated in the absence of IFN-gamma express alternative effector functions but are not protective against genital HSV-2 infection. J. Reprod. Immunol. 2010, 84:8-15.
    • (2010) J. Reprod. Immunol. , vol.84 , pp. 8-15
    • Johnson, A.J.1
  • 54
    • 65249134069 scopus 로고    scopus 로고
    • Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    • Gebhardt T., et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat. Immunol. 2009, 10:524-530.
    • (2009) Nat. Immunol. , vol.10 , pp. 524-530
    • Gebhardt, T.1
  • 55
    • 84869082967 scopus 로고    scopus 로고
    • A vaccine strategy that protects against genital herpes by establishing local memory T cells
    • Shin H., Iwasaki A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature 2012, 491:463-467.
    • (2012) Nature , vol.491 , pp. 463-467
    • Shin, H.1    Iwasaki, A.2
  • 56
    • 0035061657 scopus 로고    scopus 로고
    • + T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice
    • + T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice. J. Gen. Virol. 2001, 82:845-853.
    • (2001) J. Gen. Virol. , vol.82 , pp. 845-853
    • Harandi, A.M.1
  • 57
    • 79952724131 scopus 로고    scopus 로고
    • Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection
    • Li Z., et al. Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:4388-4393.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 4388-4393
    • Li, Z.1
  • 58
    • 0033612702 scopus 로고    scopus 로고
    • Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials
    • Corey L., et al. Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. JAMA 1999, 282:331-340.
    • (1999) JAMA , vol.282 , pp. 331-340
    • Corey, L.1
  • 59
    • 0037153024 scopus 로고    scopus 로고
    • Glycoprotein-D-adjuvant vaccine to prevent genital herpes
    • Stanberry L.R., et al. Glycoprotein-D-adjuvant vaccine to prevent genital herpes. N. Engl. J. Med. 2002, 347:1652-1661.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1652-1661
    • Stanberry, L.R.1
  • 60
    • 84855732705 scopus 로고    scopus 로고
    • Efficacy results of a trial of a herpes simplex vaccine
    • Belshe R.B., et al. Efficacy results of a trial of a herpes simplex vaccine. N. Engl. J. Med. 2012, 366:34-43.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 34-43
    • Belshe, R.B.1
  • 61
    • 77957226429 scopus 로고    scopus 로고
    • Antiviral immune responses in the genital tract: clues for vaccines
    • Iwasaki A. Antiviral immune responses in the genital tract: clues for vaccines. Nat. Rev. Immunol. 2010, 10:699-711.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 699-711
    • Iwasaki, A.1
  • 62
    • 84860788997 scopus 로고    scopus 로고
    • Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
    • Mackay L.K., et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:7037-7042.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 7037-7042
    • Mackay, L.K.1
  • 63
    • 84862777442 scopus 로고    scopus 로고
    • + TRM cells providing global skin immunity
    • + TRM cells providing global skin immunity. Nature 2012, 483:227-231.
    • (2012) Nature , vol.483 , pp. 227-231
    • Jiang, X.1
  • 64
    • 82755192260 scopus 로고    scopus 로고
    • Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection
    • Teijaro J.R., et al. Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J. Immunol. 2011, 187:5510-5514.
    • (2011) J. Immunol. , vol.187 , pp. 5510-5514
    • Teijaro, J.R.1
  • 65
    • 79951754740 scopus 로고    scopus 로고
    • Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges
    • Bomsel M., et al. Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity 2011, 34:269-280.
    • (2011) Immunity , vol.34 , pp. 269-280
    • Bomsel, M.1
  • 66
    • 55849093906 scopus 로고    scopus 로고
    • Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    • Cattamanchi A., et al. Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system. Clin. Vaccine Immunol. 2008, 15:1638-1643.
    • (2008) Clin. Vaccine Immunol. , vol.15 , pp. 1638-1643
    • Cattamanchi, A.1
  • 67
    • 38949207545 scopus 로고    scopus 로고
    • Disruption of the UL41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes
    • Dudek T., et al. Disruption of the UL41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology 2008, 372:165-175.
    • (2008) Virology , vol.372 , pp. 165-175
    • Dudek, T.1
  • 68
    • 70349348947 scopus 로고    scopus 로고
    • Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs
    • Hoshino Y., et al. Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. J. Infect. Dis. 2009, 200:1088-1095.
    • (2009) J. Infect. Dis. , vol.200 , pp. 1088-1095
    • Hoshino, Y.1
  • 69
    • 31844455180 scopus 로고    scopus 로고
    • A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects
    • de Bruyn G., et al. A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. Vaccine 2006, 24:914-920.
    • (2006) Vaccine , vol.24 , pp. 914-920
    • de Bruyn, G.1
  • 70
    • 84875548674 scopus 로고    scopus 로고
    • An adjuvanted herpes simplex virus 2 subunit vaccine elicits a T cell response in mice and is an effective therapeutic vaccine in guinea pigs
    • Skoberne M., et al. An adjuvanted herpes simplex virus 2 subunit vaccine elicits a T cell response in mice and is an effective therapeutic vaccine in guinea pigs. J. Virol. 2013, 87:3930-3942.
    • (2013) J. Virol. , vol.87 , pp. 3930-3942
    • Skoberne, M.1
  • 71
    • 82455210846 scopus 로고    scopus 로고
    • + cellular immunity and protective efficacy
    • + cellular immunity and protective efficacy. Vaccine 2011, 29:8530-8541.
    • (2011) Vaccine , vol.29 , pp. 8530-8541
    • Mo, A.1
  • 72
    • 82455192355 scopus 로고    scopus 로고
    • Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons
    • Wald A., et al. Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons. Vaccine 2011, 29:8520-8529.
    • (2011) Vaccine , vol.29 , pp. 8520-8529
    • Wald, A.1
  • 73
    • 0030772304 scopus 로고    scopus 로고
    • Protective immunity against HSV-2 in the mouse vagina
    • Parr M.B., Parr E.L. Protective immunity against HSV-2 in the mouse vagina. J. Reprod. Immunol. 1997, 36:77-92.
    • (1997) J. Reprod. Immunol. , vol.36 , pp. 77-92
    • Parr, M.B.1    Parr, E.L.2
  • 74
    • 0029809510 scopus 로고    scopus 로고
    • Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization
    • Gallichan W.S., Rosenthal K.L. Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization. J. Exp. Med. 1996, 184:1879-1890.
    • (1996) J. Exp. Med. , vol.184 , pp. 1879-1890
    • Gallichan, W.S.1    Rosenthal, K.L.2
  • 75
    • 0032579775 scopus 로고    scopus 로고
    • Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge
    • Morrison L.A., et al. Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge. Virology 1998, 243:178-187.
    • (1998) Virology , vol.243 , pp. 178-187
    • Morrison, L.A.1
  • 76
    • 79751497661 scopus 로고    scopus 로고
    • Efficient mucosal vaccination mediated by the neonatal Fc receptor
    • Ye L., et al. Efficient mucosal vaccination mediated by the neonatal Fc receptor. Nat. Biotechnol. 2011, 29:158-163.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 158-163
    • Ye, L.1
  • 77
    • 84875551472 scopus 로고    scopus 로고
    • Broadly neutralizing antiviral antibodies
    • Corti D., Lanzavecchia A. Broadly neutralizing antiviral antibodies. Annu. Rev. Immunol. 2013, 31:705-742.
    • (2013) Annu. Rev. Immunol. , vol.31 , pp. 705-742
    • Corti, D.1    Lanzavecchia, A.2
  • 78
    • 79958046992 scopus 로고    scopus 로고
    • Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons
    • Qi J., et al. Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons. The Journal of Immunology 2011, 186:6417-6426.
    • (2011) The Journal of Immunology , vol.186 , pp. 6417-6426
    • Qi, J.1


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