S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 15, 2018, Pages E3388-E3397

  Rizza, Salvatore ^a   Cardaci, Simone ^b   Montagna, Costanza ^a,c   Giacomo, Giuseppina Di ^d,l   De Zio, Daniela ^a   Bordi, Matteo ^d   Maiani, Emiliano ^a   Campello, Silvia ^d,e   Borreca, Antonella ^f   Puca, Annibale A ^g,h   Stamler, Jonathan S ^i,j   Cecconi, Francesco ^a,d,k   Filomeni, Giuseppe ^a,d  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b Scientific Institute   (Italy)

^c BISPEBJERG HOSPITAL   (Denmark)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^f CNR   (Italy)

^g IRCCS MULTIMEDICA   (Italy)

^h UNIVERSITY OF SALERNO   (Italy)

ⁱ CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^k BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^l UNIVERSITY CAMPUS BIO MEDICO   (Italy)

more..

Author keywords

Aging; GSNOR; Mitochondria; Mitophagy; S nitrosylation

Indexed keywords

GLUTATHIONE REDUCTASE; NITROSOGLUTATHIONE REDUCTASE; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; FORMALDEHYDE DEHYDROGENASE, GLUTATHIONE-INDEPENDENT; NITRIC OXIDE; S NITROSOTHIOL;

AEROBIC METABOLISM; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL AGING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; EPIGENETICS; HEK293 CELL LINE; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; LONGEVITY; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MITOPHAGY; NITROSATIVE STRESS; NITROSYLATION; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; QUALITY CONTROL; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; MAMMAL; METABOLISM; MOUSE; PROTEIN PROCESSING;

AGING; ALDEHYDE OXIDOREDUCTASES; ANIMALS; CELLULAR SENESCENCE; HUMANS; MAMMALS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL DYNAMICS; NITRIC OXIDE; NITROSATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; S-NITROSOTHIOLS;

EID: 85045103676     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1722452115     Document Type: Article

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