S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis

Science Translational Medicine

Volumn 2, Issue 19, 2010, Pages

  Wei, Wei ^a   Li, Bin ^a   Hanes, Martha A ^b   Kakar, Sanjay ^c   Chen, Xin ^c   Liu, Limin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; DIETHYLNITROSAMINE; DNA; GLUTATHIONE REDUCTASE; INDUCIBLE NITRIC OXIDE SYNTHASE; S NITROSOGLUTATHIONE REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; FEMALE; GENE DELETION; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; MOUSE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CARCINOMA, HEPATOCELLULAR; DNA REPAIR; FEMALE; GENE DELETION; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROTEASOME ENDOPEPTIDASE COMPLEX; S-NITROSOTHIOLS; SURVIVAL RATE;

EID: 77952963414     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3000328     Document Type: Article

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