The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species

Developmental Cell

Volumn 40, Issue 6, 2017, Pages 583-594.e6

  Bordt, Evan A ^a   Clerc, Pascaline ^a   Roelofs, Brian A ^a   Saladino, Andrew J ^a,b   Tretter, László ^c   Adam Vizi, Vera ^c   Cherok, Edward ^a   Khalil, Ahmed ^d,e   Yadava, Nagendra ^d,e,f   Ge, Shealinna X ^a   Francis, T Chase ^a   Kennedy, Nolan W ^g   Picton, Lora K ^h   Kumar, Tanya ^a   Uppuluri, Sruti ^a   Miller, Alexandrea M ^a   Itoh, Kie ^h   Karbowski, Mariusz ^a   Sesaki, Hiromi ^h   Hill, R Blake ^g   Polster, Brian M ^a   more..

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d Pioneer Valley Life Sciences Institute   (United States)

^e BAYSTATE MEDICAL CENTER   (United States)

^f UNIVERSITY OF MASSACHUSETTS   (United States)

^g MEDICAL COLLEGE OF WISCONSIN   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bioenergetics; brain; fission; fragmentation; mitochondria; neuron; respiration; reverse electron transfer; succinate; superoxide

Indexed keywords

DYNAMIN RELATED PROTEIN 1; GUANOSINE TRIPHOSPHATASE; HYDROLASE INHIBITOR; MDIVI 1; OXYGEN; PROTEIN NDI1; QUINAZOLINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG; 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-SULFANYL-4(3H)-QUINAZOLINONE; DNM1L PROTEIN, HUMAN; DNM1L PROTEIN, MOUSE; DYNAMIN; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; NDI1 PROTEIN, S CEREVISIAE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SACCHAROMYCES CEREVISIAE PROTEIN;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRON TRANSPORT; ENZYME ACTIVITY; FIBROBLAST; MITOCHONDRIAL RESPIRATION; NERVE CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL RESPIRATION; CHLOROCEBUS AETHIOPS; COS CELL LINE; DRUG EFFECTS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MOUSE; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; SACCHAROMYCES CEREVISIAE; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; CELL RESPIRATION; CERCOPITHECUS AETHIOPS; COS CELLS; DYNAMINS; ELECTRON TRANSPORT COMPLEX I; FIBROBLASTS; GTP PHOSPHOHYDROLASES; HUMANS; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NAD; NEURONS; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; QUINAZOLINONES; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 85016487669     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2017.02.020     Document Type: Article

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