Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

Cell Host and Microbe

Volumn 23, Issue 2, 2018, Pages 254-265.e7

  Maruzuru, Yuhei ^a,b   Ichinohe, Takeshi ^a   Sato, Ryota ^a   Miyake, Kensuke ^a   Okano, Tokuju ^c   Suzuki, Toshihiko ^c   Koshiba, Takumi ^d   Koyanagi, Naoto ^a   Tsuda, Shumpei ^a   Watanabe, Mizuki ^a   Arii, Jun ^a   Kato, Akihisa ^a   Kawaguchi, Yasushi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

AIM2; herpes simplex virus; HSV 1; immune evasion; inflammasome

Indexed keywords

AIM2 PROTEIN; DNA; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; PROTEIN VP22; PYRIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; CRYOPYRIN; DNA BINDING PROTEIN; HERPES SIMPLEX VIRUS TYPE 1 PROTEIN VP22; IL1B PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; SMALL INTERFERING RNA; VIRAL PROTEIN; VIRUS DNA;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CONTROLLED STUDY; CYTOKINE RELEASE; ECTOPIC EXPRESSION; FEMALE; GENETIC TRANSFECTION; HEK293-FT CELL LINE; HERPES SIMPLEX; HUMAN ALPHAHERPESVIRUS 1; IN VIVO STUDY; J774A1 CELL LINE; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRION; VIRUS ENTRY; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CHLOROCEBUS AETHIOPS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; METABOLISM; RNA INTERFERENCE; SECRETION (PROCESS); VERO CELL LINE;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; DNA, VIRAL; DNA-BINDING PROTEINS; FEMALE; HERPESVIRUS 1, HUMAN; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; VERO CELLS; VIRAL STRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 85044778268     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2017.12.014     Document Type: Article

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