hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model

Stem Cell Reports

Volumn 10, Issue 5, 2018, Pages 1481-1491

  Adil, Maroof M ^a   Gaj, Thomas ^b   Rao, Antara T ^a   Kulkarni, Rishikesh U ^a   Fuentes, Christina M ^b   Ramadoss, Gokul N ^a   Ekman, Freja K ^a   Miller, Evan W ^a   Schaffer, David V ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

Author keywords

biomaterials; cell replacement therapy; differentiation; human pluripotent stem cells; Huntington disease; medium spiny neurons

Indexed keywords

4 AMINOBUTYRIC ACID; BIOLOGICAL MARKER; CALBINDIN; DARPP32 PROTEIN; DICKKOPF 1 PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP1; TRANSCRIPTION FACTOR FOXP2; TRANSCRIPTION FACTOR GSX2; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG; SONIC HEDGEHOG PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; HYDROGEL; MEDIUM SPINY NEURON; MOTOR COORDINATION; MOUSE; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL TRANSPLANTATION; SURVIVAL; TRANSGENIC MOUSE; ACTION POTENTIAL; ANIMAL; CELL DIFFERENTIATION; CELL SURVIVAL; CORPUS STRIATUM; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; METABOLISM; NERVE CELL; PATHOLOGY; PHARMACOLOGY; TRANSPLANTATION; WNT SIGNALING;

ACTION POTENTIALS; ANIMALS; CELL DIFFERENTIATION; CELL SURVIVAL; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; HEDGEHOG PROTEINS; HUMANS; HUNTINGTON DISEASE; HYDROGELS; MICE; NEURONS; PHENOTYPE; PLURIPOTENT STEM CELLS; WNT SIGNALING PATHWAY;

EID: 85044758179     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2018.03.007     Document Type: Article

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