Erratum to: Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons (Nature Neuroscience, (2014), 17, 8, (1064-1072), 10.1038/nn.3761);Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons

Nature Neuroscience

Volumn 17, Issue 8, 2014, Pages 1064-1072

  Pecho Vrieseling, Eline ^a   Rieker, Claus ^a   Fuchs, Sascha ^a   Bleckmann, Dorothee ^a   Esposito, Maria Soledad ^b,c   Botta, Paolo ^b   Goldstein, Chris ^a   Bernhard, Mario ^a   Galimberti, Ivan ^a   Müller, Matthias ^a   Lüthi, Andreas ^b   Arber, Silvia ^b,c   Bouwmeester, Tewis ^a   Van Der Putten, Herman ^a,d   Di Giorgio, Francesco Paolo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d National Contest for Life Foundation   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; DOUBLECORTIN; HUNTINGTIN; MUTANT HUNTINGTIN; PHOSPHOPROTEIN DARPP 32; RETINOIC ACID; SYNAPTOPHYSIN; TRITON X 100; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SLICE; CELL ACTIVITY; CELL COUNT; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; EMBRYOID BODY; EMBRYONIC STEM CELL; EX VIVO STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IMMUNOFLUORESCENCE; IN VIVO STUDY; MIXED CELL CULTURE; MOUSE; NEUROFILAMENT; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT; STAINING; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; TRANSNEURONAL PROPAGATION;

ANIMALS; CELL LINE; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; FEMALE; GENOTYPE; HUMANS; HUNTINGTON DISEASE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MUTATION; NERVE NET; NERVE TISSUE PROTEINS; NEURONS;

EID: 84905023942     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/s41593-018-0201-6     Document Type: Erratum

References (59)

1. The Huntington?s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington?s disease chromosomes. Cell 72, 971-983 (1993
2. Ross, C.A.&Tabrizi, S.J. Huntington?s disease: From molecular pathogenesis to clinical treatment. Lancet Neurol. 10, 83-98 (2011
3. Landles, C. et al. Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. J. Biol. Chem. 285, 8808-8823 (2010
4. Sathasivam, K. et al. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc. Natl. Acad. Sci. USA 110, 2366-2370 (2013
5. Mangiarini, L. et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493-506 (1996
6. Arrasate, M.&Finkbeiner, S. Protein aggregates in Huntington?s disease. Exp. Neurol. 238, 1-11 (2012
7. Raymond, L.A. et al. Pathophysiology of Huntington?s disease: Time-dependent alterations in synaptic and receptor function. Neuroscience 198, 252-273 (2011
8. Hong, S.L. et al. Dysfunctional behavioral modulation of corticostriatal communication in the R6/2 mouse model of Huntington?s disease. PLoS ONE 7, e47026 (2012
9. Ehrlich, M.E. Huntington?s disease and the striatal medium spiny neuron: Cell-Autonomous and non-cell-Autonomous mechanisms of disease. Neurotherapeutics 9, 270-284 (2012
10. Cepeda, C. et al. Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington?s disease. J. Neurosci. 23, 961-969 (2003
11. Stack, E.C.&Ferrante, R.J. Huntington?s disease: Progress and potential in the field. Expert Opin. Investig. Drugs 16, 1933-1953 (2007
12. Gu, X. et al. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron 46, 433-444 (2005
13. Gray, M. et al. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J. Neurosci. 28, 6182-6195 (2008
14. Aguzzi, A. Cell biology: Beyond the prion principle. Nature 459, 924-925 (2009
15. Guo, J.L.&Lee, V.M. Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nat. Med. 20, 130-138 (2014
16. Raj, A., Kuceyeski, A.&Weiner, M. A network diffusion model of disease progression in dementia. Neuron 73, 1204-1215 (2012
17. Zhou, J., Gennatas, E.D., Kramer, J.H., Miller, B.L.&Seeley, W.W. Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron 73, 1216-1227 (2012
18. Ren, P.H. et al. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat. Cell Biol. 11, 219-225 (2009
19. Gousset, K. et al. Prions hijack tunnelling nanotubes for intercellular spread. Nat. Cell Biol. 11, 328-336 (2009
20. Constanzo, M. et al. Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes. J. Cell Sci. 126, 3678-3685 (2013
21. Simpson, L.L. Identification of the major steps in botulinum toxin action. Annu. Rev. Pharmacol. Toxicol. 44, 167-193 (2004
22. Südhof, T.C.&Rizo, J. Synaptic vesicle exocytosis. Cold Spring Harb. Perspect. Biol. 3, a005637 (2011
23. Letzkus, J.J. et al. A disinhibitory microcircuit for associative fear learning in the auditory cortex. Nature 480, 331-335 (2011
24. Svenningsson, P. et al. DARPP-32: An integrator of neurotransmission. Annu. Rev. Pharmacol. Toxicol. 44, 269-296 (2004
25. Greig, L.C., Woodworth, M.B., Galazo, M.J., Padmanabhan, H.&Macklis, J.D. Molecular logic of neocortical projection neuron specification, development and diversity. Nat. Rev. Neurosci. 14, 755-769 (2013
26. Yu, D.X., Marchetto, M.C.&Gage, F.H. How to make a hippocampal dentate gyrus granule neuron. Development 141, 2366-2375 (2014
27. Proenca, C.C. et al. Atg4b-dependent autophagic flux alleviates Huntington?s disease progression. PLoS ONE 8, e68357 (2013
28. Hickey, M.A. et al. Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington?s disease mice. Neuroscience 157, 280-295 (2008
29. Li, H. et al. Ultrastructural localization and progressive formation of neuropil aggregates in Huntington?s disease transgenic mice. Hum. Mol. Genet. 8, 1227-1236 (1999
30. Klapstein, G.J. et al. Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington?s disease transgenic mice. J. Neurophysiol. 86, 2667-2677 (2001
31. Esposito, M.S., Capelli, P.&Arber, S. Brainstem nucleus MdV mediates skilled forelimb motor tasks. Nature 508, 351-356 (2014
32. Li, H., Wyman, T., Yu, Z.X., Li, S.H.&Li, X.J. Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Hum. Mol. Genet. 12, 2021-2030 (2003
33. Wickersham, I.R., Sullivan, H.A.&Seung, H.S. Axonal and subcellular labelling using modified rabies viral vectors. Nat. Commun. 4, 2332 (2013
34. Pivetta, C., Esposito, M.S., Sigrist, M.&Arber, S. Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin. Cell 156, 537-548 (2014
35. Foran, P.G. et al. Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons. J. Biol. Chem. 278, 1363-1371 (2003
36. Vonsattel, J.P. Huntington disease models and human neuropathology: Similarities and differences. Acta Neuropathol. 115, 55-69 (2008
37. Ma, L. et al. Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell 10, 455-464 (2012
38. Cicchetti, F. et al. Neural transplants in patients with Huntington?s disease undergo disease-like neuronal degeneration. Proc. Natl. Acad. Sci. USA 106, 12483-12488 (2009
39. Aguzzi, A.&Rajendran, L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 64, 783-790 (2009
40. Braak, H. et al. Staging of brain pathology related to sporadic Parkinson?s disease. Neurobiol. Aging 24, 197-211 (2003
41. De Calignon, A. et al. Propagation of tau pathology in a model of early Alzheimer?s disease. Neuron 73, 685-697 (2012
42. Liu, L. et al. Trans-synaptic spread of tau pathology in vivo. PLoS ONE 7, e31302 (2012
43. Dujardin, S. et al. Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: Relevance to sporadic tauopathies. Acta Neuropathol. Commun. 2, 14 (2014
44. Neale, E.A., Bowers, L.M., Jia, M., Bateman, K.E.&Williamson, L.C. Botulinum neurotoxin A blocks synaptic vesicle exocytosis but not endocytosis at the nerve terminal. J. Cell Biol. 147, 1249-1260 (1999
45. Pooler, A.M., Phillips, E.C., Lau, D.H., Noble, W.&Hanger, D.P. Physiological release of endogenous tau is stimulated by neuronal activity. EMBO Rep. 14, 389-394 (2013
46. Yamada, K. et al. Neuronal activity regulates extracellular tau in vivo. J. Exp. Med. 211, 387-393 (2014
47. Volpicelli-Daley, L.A. et al. Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72, 57-71 (2011
48. Gutekunst, C.A. et al. Nuclear and neuropil aggregates in Huntington?s disease: Relationship to neuropathology. J. Neurosci. 19, 2522-2534 (1999
49. Tabrizi, S.J. et al. Biological and clinical changes in premanifest and early stage Huntington?s disease in the TRACK-HD study: The 12-month longitudinal analysis. Lancet Neurol. 10, 31-42 (2011
50. Thomson, J.A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998
51. Weiss, A. et al. Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington?s disease. Anal. Biochem. 395, 8-15 (2009
52. Gogolla, N., Galimberti, I., DePaola, V.&Caroni, P. Staining protocol for organotypic hippocampal slice cultures. Nat. Protoc. 1, 2452-2456 (2006
53. Tchorz, J.S. et al. A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters. PLoS ONE 7, e30011 (2012
54. Ko, J., Ou, S.&Patterson, P.H. New anti-huntingtin monoclonal antibodies: Implications for huntingtin conformation and its binding proteins. Brain Res. Bull. 56, 319-329 (2001
55. Franklin, J.&Paxinos, G. Mouse Brain in Stereotaxic Coordinates (Academic Press, 2012
56. Baldo, B. et al. TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington?s disease. Chem. Biol. 19, 264-275 (2012
57. Bobrowska, A., Donmez, G., Weiss, A., Guarente, L.&Bates, G. SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington?s disease phenotypes in vivo. PLoS ONE 7, e34805 (2012
58. Di Giorgio, F.P., Carrasco, M.A., Siao, M.C., Maniatis, T.&Eggan, K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 10, 608-614 (2007
59. Luk, K.C. et al. Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338, 949-953 (2012