메뉴 건너뛰기




Volumn 32, Issue 19, 2012, Pages 6456-6467

R6/2 huntington's disease mice develop early and progressive abnormal brain metabolism and seizures

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE;

EID: 84860690256     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0388-12.2012     Document Type: Article
Times cited : (68)

References (66)
  • 2
    • 0034784359 scopus 로고    scopus 로고
    • An energy budget for signaling in the grey matter of the brain
    • Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21:1133-1145.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1133-1145
    • Attwell, D.1    Laughlin, S.B.2
  • 4
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phe-notype in the adult brain and during brain aging
    • Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and neuronal phe-notype in the adult brain and during brain aging. Neuron 68:409-427.
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    Larue, B.5    Deane, R.6    Zlokovic, B.V.7
  • 5
    • 45549085845 scopus 로고    scopus 로고
    • Magnetic resonance imaging asan approach towards identifying neuropathological biomarkers for Huntington's disease
    • Bohanna I, Georgiou-Karistianis N, Hannan AJ, Egan GF (2008) Magnetic resonance imaging asan approach towards identifying neuropathological biomarkers for Huntington's disease. Brain Res Rev 58:209-225.
    • (2008) Brain Res Rev , vol.58 , pp. 209-225
    • Bohanna, I.1    Georgiou-Karistianis, N.2    Hannan, A.J.3    Egan, G.F.4
  • 6
    • 34250304323 scopus 로고    scopus 로고
    • The relationship between blood flow and neuronal activity in the rodent olfactory bulb
    • Chaigneau E, Tiret P, Lecoq J, Ducros M, Knöpfel T, Charpak S (2007) The relationship between blood flow and neuronal activity in the rodent olfactory bulb. J Neurosci 27:6452-6460.
    • (2007) J Neurosci , vol.27 , pp. 6452-6460
    • Chaigneau, E.1    Tiret, P.2    Lecoq, J.3    Ducros, M.4    Knöpfel, T.5    Charpak, S.6
  • 7
    • 0033604028 scopus 로고    scopus 로고
    • Nuclear medicine in neurology and psychiatry
    • Costa DC, Pilowsky LS, Ell PJ (1999) Nuclear medicine in neurology and psychiatry. Lancet 354:1107-1111.
    • (1999) Lancet , vol.354 , pp. 1107-1111
    • Costa, D.C.1    Pilowsky, L.S.2    Ell, P.J.3
  • 9
    • 0036787479 scopus 로고    scopus 로고
    • Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease
    • Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD (2002) Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain 125:2332-2341.
    • (2002) Brain , vol.125 , pp. 2332-2341
    • Dixon, R.M.1    Bradley, K.M.2    Budge, M.M.3    Styles, P.4    Smith, A.D.5
  • 11
    • 0028895133 scopus 로고
    • Functional MR in the evaluation of dementia: Correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18
    • González RG, Fischman AJ, Guimaraes AR, Carr CA, Stern CE, Halpern EF, Growdon JH, Rosen BR (1995) Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18. AJNR Am J Neuroradiol 16:1763-1770.
    • (1995) AJNR Am J Neuroradiol , vol.16 , pp. 1763-1770
    • González, R.G.1    Fischman, A.J.2    Guimaraes, A.R.3    Carr, C.A.4    Stern, C.E.5    Halpern, E.F.6    Growdon, J.H.7    Rosen, B.R.8
  • 13
    • 73349121682 scopus 로고    scopus 로고
    • Sensitivity of neural-hemodynamic coupling to alterations in ce rebral blood flow during hypercapnia
    • Huppert TJ, Jones PB, Devor A, Dunn AK, Teng IC, Dale AM, Boas DA (2009)Sensitivity of neural-hemodynamic coupling to alterations in ce rebral blood flow during hypercapnia. J Biomed Opt 14:044038.
    • (2009) J Biomed Opt , vol.14 , pp. 044038
    • Huppert, T.J.1    Jones, P.B.2    Devor, A.3    Dunn, A.K.4    Teng, I.C.5    Dale, A.M.6    Boas, D.A.7
  • 15
    • 3242741992 scopus 로고    scopus 로고
    • A comparison of hemodynamic and neural responses in cat visual cortex using complex stimuli
    • Kayser C, Kim M, Ugurbil K, Kim DS, König P (2004) A comparison of hemodynamic and neural responses in cat visual cortex using complex stimuli. Cereb Cortex 14:881-891.
    • (2004) Cereb Cortex , vol.14 , pp. 881-891
    • Kayser, C.1    Kim, M.2    Ugurbil, K.3    Kim, D.S.4    König, P.5
  • 16
    • 67649961867 scopus 로고    scopus 로고
    • Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices
    • Kovács R, Rabanus A, Otáhal J, Patzak A, Kardos J, Albus K, Heinemann U, Kann O (2009) Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices. J Neurosci 29:8565-8577.
    • (2009) J Neurosci , vol.29 , pp. 8565-8577
    • Kovács, R.1    Rabanus, A.2    Otáhal, J.3    Patzak, A.4    Kardos, J.5    Albus, K.6    Heinemann, U.7    Kann, O.8
  • 17
    • 11144228439 scopus 로고    scopus 로고
    • Reading vascular changes in brain imaging: Is dendritic calcium the key?
    • Lauritzen M (2005) Reading vascular changes in brain imaging: is dendritic calcium the key? Nat Rev Neurosci 6:77-85.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 77-85
    • Lauritzen, M.1
  • 18
    • 0032421512 scopus 로고    scopus 로고
    • Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats
    • Lenz C, Rebel A, van Ackern K, Kuschinsky W, Waschke KF (1998) Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats. Anesthesiology 89:1480-1488.
    • (1998) Anesthesiology , vol.89 , pp. 1480-1488
    • Lenz, C.1    Rebel, A.2    van Ackern, K.3    Kuschinsky, W.4    Waschke, K.F.5
  • 21
    • 26844498655 scopus 로고    scopus 로고
    • The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies
    • Li JY, Popovic N, Brundin P (2005) The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx 2:447-464.
    • (2005) NeuroRx , vol.2 , pp. 447-464
    • Li, J.Y.1    Popovic, N.2    Brundin, P.3
  • 22
    • 0032907631 scopus 로고    scopus 로고
    • Regional cerebral blood volume: A comparison ofthe dynamic imaging and the steady state methods
    • Lin W, Celik A, Paczynski RP (1999) Regional cerebral blood volume: a comparison ofthe dynamic imaging and the steady state methods.J Magn Reson Imaging 9:44-52.
    • (1999) J Magn Reson Imaging , vol.9 , pp. 44-52
    • Lin, W.1    Celik, A.2    Paczynski, R.P.3
  • 23
    • 13544260698 scopus 로고    scopus 로고
    • On the nature of the BOLD fMRI contrast mechanism
    • Logothetis NK, Pfeuffer J (2004) On the nature of the BOLD fMRI contrast mechanism. Magn Reson Imaging 22:1517-1531.
    • (2004) Magn Reson Imaging , vol.22 , pp. 1517-1531
    • Logothetis, N.K.1    Pfeuffer, J.2
  • 24
  • 25
    • 0030792553 scopus 로고    scopus 로고
    • GABAergic neurons in barrel cortex show strong, whisker-dependent metabolic activation during normal behavior
    • McCasland JS, Hibbard LS (1997) GABAergic neurons in barrel cortex show strong, whisker-dependent metabolic activation during normal behavior. J Neurosci 17:5509-5527.
    • (1997) J Neurosci , vol.17 , pp. 5509-5527
    • McCasland, J.S.1    Hibbard, L.S.2
  • 27
    • 79551518229 scopus 로고    scopus 로고
    • Energy deficit in Huntington disease: Why it matters
    • Mochel F, Haller RG (2011) Energy deficit in Huntington disease: why it matters. J Clin Invest 121:493-499.
    • (2011) J Clin Invest , vol.121 , pp. 493-499
    • Mochel, F.1    Haller, R.G.2
  • 28
    • 33747372188 scopus 로고    scopus 로고
    • Longitudinal mapping of mouse cerebral blood volume with MRI
    • Moreno H, Hua F, Brown T, Small S (2006) Longitudinal mapping of mouse cerebral blood volume with MRI. NMR Biomed 19:535-543.
    • (2006) NMR Biomed , vol.19 , pp. 535-543
    • Moreno, H.1    Hua, F.2    Brown, T.3    Small, S.4
  • 31
    • 0141744905 scopus 로고    scopus 로고
    • Age-dependent impairmentofsomatosensory responseinthe amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease
    • Mueggler T, Baumann D, Rausch M, Staufenbiel M, Rudin M (2003) Age-dependent impairmentofsomatosensory responseinthe amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease. J Neurosci 23:8231-8236.
    • (2003) J Neurosci , vol.23 , pp. 8231-8236
    • Mueggler, T.1    Baumann, D.2    Rausch, M.3    Staufenbiel, M.4    Rudin, M.5
  • 33
    • 4544367820 scopus 로고    scopus 로고
    • Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: High-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry
    • Nehlig A, Wittendorp-Rechenmann E, Lam CD (2004) Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry. J Cereb Blood Flow Metab 24:1004-1014.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 1004-1014
    • Nehlig, A.1    Wittendorp-Rechenmann, E.2    Lam, C.D.3
  • 35
    • 69549086367 scopus 로고    scopus 로고
    • Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex
    • Piilgaard H, Lauritzen M (2009) Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex. J Cereb Blood Flow Metab 29:1517-1527.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1517-1527
    • Piilgaard, H.1    Lauritzen, M.2
  • 37
    • 0015309163 scopus 로고
    • Modification of seizure activity by electrical stimulation. II. Motor seizure
    • Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294.
    • (1972) Electroencephalogr Clin Neurophysiol , vol.32 , pp. 281-294
    • Racine, R.J.1
  • 38
    • 0034705201 scopus 로고    scopus 로고
    • Functional brain imaging to identify affected subjects genetically at risk for Alzheimer's disease
    • Rapoport SI (2000) Functional brain imaging to identify affected subjects genetically at risk for Alzheimer's disease. Proc Natl Acad Sci U S A 97:5696-5698.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5696-5698
    • Rapoport, S.I.1
  • 42
    • 0038650885 scopus 로고    scopus 로고
    • In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: Implications for brain function
    • Rothman DL, Behar KL, Hyder F, Shulman RG (2003) In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol 65:401-427.
    • (2003) Annu Rev Physiol , vol.65 , pp. 401-427
    • Rothman, D.L.1    Behar, K.L.2    Hyder, F.3    Shulman, R.G.4
  • 44
    • 57449088803 scopus 로고    scopus 로고
    • Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease
    • Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009a) Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease. Neurobiol Dis 33:12-19.
    • (2009) Neurobiol Dis , vol.33 , pp. 12-19
    • Sawiak, S.J.1    Wood, N.I.2    Williams, G.B.3    Morton, A.J.4    Carpenter, T.A.5
  • 45
    • 57449107357 scopus 로고    scopus 로고
    • Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry
    • Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009b) Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry. Neu-robiol Dis 33:20-27.
    • (2009) Neu-robiol Dis , vol.33 , pp. 20-27
    • Sawiak, S.J.1    Wood, N.I.2    Williams, G.B.3    Morton, A.J.4    Carpenter, T.A.5
  • 46
    • 29144460321 scopus 로고    scopus 로고
    • Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
    • Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ (2005) Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. J Cell Biol 171:1001-1012.
    • (2005) J Cell Biol , vol.171 , pp. 1001-1012
    • Shin, J.Y.1    Fang, Z.H.2    Yu, Z.X.3    Wang, C.E.4    Li, S.H.5    Li, X.J.6
  • 49
    • 0033772434 scopus 로고    scopus 로고
    • Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer's disease and aging
    • Small SA, Nava AS, Perera GM, Delapaz R, Stern Y (2000b) Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer's disease and aging. Microsc Res Tech 51:101-108.
    • (2000) Microsc Res Tech , vol.51 , pp. 101-108
    • Small, S.A.1    Nava, A.S.2    Perera, G.M.3    Delapaz, R.4    Stern, Y.5
  • 50
    • 0017368491 scopus 로고
    • The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat
    • Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neuro-chem 28:897-916.
    • (1977) J Neuro-chem , vol.28 , pp. 897-916
    • Sokoloff, L.1    Reivich, M.2    Kennedy, C.3    des Rosiers, M.H.4    Patlak, C.S.5    Pettigrew, K.D.6    Sakurada, O.7    Shinohara, M.8
  • 52
    • 33846970909 scopus 로고    scopus 로고
    • Neurochem-ical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy
    • Tkac I, Dubinsky JM, Keene CD, Gruetter R, Low WC (2007) Neurochem-ical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy. J Neurochem 100:1397-1406.
    • (2007) J Neurochem , vol.100 , pp. 1397-1406
    • Tkac, I.1    Dubinsky, J.M.2    Keene, C.D.3    Gruetter, R.4    Low, W.C.5
  • 53
    • 31344481746 scopus 로고    scopus 로고
    • Standardization of a novel blood-sampling method through the jugular vein for use in the quantified [14C] 2-deoxyglucose method
    • Torres-Reverón A, Melnick SM, Stephenson SI, Dow-Edwards DL (2006) Standardization of a novel blood-sampling method through the jugular vein for use in the quantified [14C] 2-deoxyglucose method. J Neurosci Methods 150:143-149.
    • (2006) J Neurosci Methods , vol.150 , pp. 143-149
    • Torres-Reverón, A.1    Melnick, S.M.2    Stephenson, S.I.3    Dow-Edwards, D.L.4
  • 54
    • 0031883407 scopus 로고    scopus 로고
    • Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging
    • van Zijl PC, Eleff SM, Ulatowski JA, Oja JM, Uluǧ AM, Traystman RJ, Kaup-pinen RA (1998) Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 4:159-167.
    • (1998) Nat Med , vol.4 , pp. 159-167
    • van Zijl, P.C.1    Eleff, S.M.2    Ulatowski, J.A.3    Oja, J.M.4    Uluǧ, A.M.5    Traystman, R.J.6    Kaup-Pinen, R.A.7
  • 55
    • 78149338317 scopus 로고    scopus 로고
    • Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI
    • Vlachos F, Tung YS, Konofagou EE (2010) Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI. Phys Med Biol 55:5451-5466.
    • (2010) Phys Med Biol , vol.55 , pp. 5451-5466
    • Vlachos, F.1    Tung, Y.S.2    Konofagou, E.E.3
  • 58
    • 13544272671 scopus 로고    scopus 로고
    • Vessels and nerves: Marching to the same tune
    • Weinstein BM (2005) Vessels and nerves: marching to the same tune. Cell 120:299-302.
    • (2005) Cell , vol.120 , pp. 299-302
    • Weinstein, B.M.1
  • 59
    • 0028321471 scopus 로고
    • Microscopic susceptibility variation and transverse relaxation: Theory and experiment
    • Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR (1994) Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 31:601-610.
    • (1994) Magn Reson Med , vol.31 , pp. 601-610
    • Weisskoff, R.M.1    Zuo, C.S.2    Boxerman, J.L.3    Rosen, B.R.4
  • 60
    • 0037380109 scopus 로고    scopus 로고
    • High-resolution in vivo CBV mapping with MRIinwild-type mice
    • Wu EX, Wong KK, Andrassy M, Tang H (2003) High-resolution in vivo CBV mapping with MRIinwild-type mice. Magn Reson Med 49:765-770.
    • (2003) Magn Reson Med , vol.49 , pp. 765-770
    • Wu, E.X.1    Wong, K.K.2    Andrassy, M.3    Tang, H.4
  • 61
    • 33846114647 scopus 로고    scopus 로고
    • Imaging the earliest stages of Alzheimer's disease
    • Wu W, Small SA (2006) Imaging the earliest stages of Alzheimer's disease. Curr Alzheimer Res 3:529-539.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 529-539
    • Wu, W.1    Small, S.A.2
  • 64
    • 33744930583 scopus 로고    scopus 로고
    • User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability
    • Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, Gerig G (2006) User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31:1116-1128.
    • (2006) Neuroimage , vol.31 , pp. 1116-1128
    • Yushkevich, P.A.1    Piven, J.2    Hazlett, H.C.3    Smith, R.G.4    Ho, S.5    Gee, J.C.6    Gerig, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.