메뉴 건너뛰기




Volumn 10, Issue 3, 2018, Pages 426-443

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; GLYCOPROTEINS; MAMMALS; NEURODEGENERATIVE DISEASES; ORGANOMETALLICS; PROTEINS;

EID: 85044209474     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c8mt00004b     Document Type: Article
Times cited : (35)

References (65)
  • 1
    • 84961042345 scopus 로고
    • The effect of age on the non-haemin iron in the human brain
    • B. Hallgren P. Sourander The effect of age on the non-haemin iron in the human brain J. Neurochem. 1958 3 1 41 51
    • (1958) J. Neurochem. , vol.3 , Issue.1 , pp. 41-51
    • Hallgren, B.1    Sourander, P.2
  • 2
    • 0021329973 scopus 로고
    • The regional distribution and cellular localization of iron in the rat brain
    • J. M. Hill R. C. Switzer 3rd The regional distribution and cellular localization of iron in the rat brain Neuroscience 1984 11 3 595 603
    • (1984) Neuroscience , vol.11 , Issue.3 , pp. 595-603
    • Hill, J.M.1    Switzer, R.C.2
  • 3
    • 84920590033 scopus 로고    scopus 로고
    • Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution
    • S. C. Cunnane M. A. Crawford Energetic and nutritional constraints on infant brain development: implications for brain expansion during human evolution J. Hum. Evol. 2014 77 88 98
    • (2014) J. Hum. Evol. , vol.77 , pp. 88-98
    • Cunnane, S.C.1    Crawford, M.A.2
  • 4
    • 84904668549 scopus 로고    scopus 로고
    • Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats
    • A. R. Greminger D. L. Lee P. Shrager M. Mayer-Proschel Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats J. Nutr. 2014 144 7 1058 1066
    • (2014) J. Nutr. , vol.144 , Issue.7 , pp. 1058-1066
    • Greminger, A.R.1    Lee, D.L.2    Shrager, P.3    Mayer-Proschel, M.4
  • 5
    • 84901323597 scopus 로고    scopus 로고
    • Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age
    • B. Lozoff M. Castillo K. M. Clark J. B. Smith J. Sturza Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age J. Nutr. 2014 144 6 838 845
    • (2014) J. Nutr. , vol.144 , Issue.6 , pp. 838-845
    • Lozoff, B.1    Castillo, M.2    Clark, K.M.3    Smith, J.B.4    Sturza, J.5
  • 6
    • 75149152568 scopus 로고    scopus 로고
    • Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
    • M. A. Smith X. Zhu M. Tabaton et al., Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment J. Alzheimer's Dis. 2010 19 1 363 372
    • (2010) J. Alzheimer's Dis. , vol.19 , Issue.1 , pp. 363-372
    • Smith, M.A.1    Zhu, X.2    Tabaton, M.3
  • 7
    • 0347928847 scopus 로고    scopus 로고
    • An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
    • J. T. Rogers J. D. Randall C. M. Cahill et al., An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript J. Biol. Chem. 2002 277 47 45518 45528
    • (2002) J. Biol. Chem. , vol.277 , Issue.47 , pp. 45518-45528
    • Rogers, J.T.1    Randall, J.D.2    Cahill, C.M.3
  • 8
    • 84914693430 scopus 로고    scopus 로고
    • Beta-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin
    • B. X. Wong A. Tsatsanis L. Q. Lim P. A. Adlard A. I. Bush J. A. Duce beta-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin PLoS One 2014 9 12 e114174
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e114174
    • Wong, B.X.1    Tsatsanis, A.2    Lim, L.Q.3    Adlard, P.A.4    Bush, A.I.5    Duce, J.A.6
  • 9
    • 47849086918 scopus 로고    scopus 로고
    • Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material
    • J. F. Collingwood R. K. Chong T. Kasama et al., Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material J. Alzheimer's Dis. 2008 14 2 235 245
    • (2008) J. Alzheimer's Dis. , vol.14 , Issue.2 , pp. 235-245
    • Collingwood, J.F.1    Chong, R.K.2    Kasama, T.3
  • 10
    • 84938500229 scopus 로고    scopus 로고
    • Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1DeltaE9 mice: A histological perspective
    • M. D. Meadowcroft J. R. Connor Q. X. Yang Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1DeltaE9 mice: a histological perspective Front. Neurosci. 2015 9 255
    • (2015) Front. Neurosci. , vol.9 , pp. 255
    • Meadowcroft, M.D.1    Connor, J.R.2    Yang, Q.X.3
  • 11
    • 84896382482 scopus 로고    scopus 로고
    • Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide beta-amyloid
    • J. Everett E. Cespedes L. R. Shelford et al., Evidence of redox-active iron formation following aggregation of ferrihydrite and the Alzheimer's disease peptide beta-amyloid Inorg. Chem. 2014 53 6 2803 2809
    • (2014) Inorg. Chem. , vol.53 , Issue.6 , pp. 2803-2809
    • Everett, J.1    Cespedes, E.2    Shelford, L.R.3
  • 12
    • 84901455157 scopus 로고    scopus 로고
    • Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide beta-amyloid (1-42)
    • J. Everett E. Cespedes L. R. Shelford et al., Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide beta-amyloid (1-42) J. R. Soc., Interface 2014 11 95 20140165
    • (2014) J. R. Soc., Interface , vol.11 , Issue.95 , pp. 20140165
    • Everett, J.1    Cespedes, E.2    Shelford, L.R.3
  • 13
    • 0026513756 scopus 로고
    • A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains
    • J. R. Connor S. L. St. Menzies S. M. Martin E. J. Mufson A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains J. Neurosci. Res. 1992 31 1 75 83
    • (1992) J. Neurosci. Res. , vol.31 , Issue.1 , pp. 75-83
    • Connor, J.R.1    St. Menzies, S.L.2    Martin, S.M.3    Mufson, E.J.4
  • 14
    • 84940467351 scopus 로고    scopus 로고
    • Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease
    • M. M. Zeineh Y. Chen H. H. Kitzler R. Hammond H. Vogel B. K. Rutt Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease Neurobiol. Aging 2015 36 9 2483 2500
    • (2015) Neurobiol. Aging , vol.36 , Issue.9 , pp. 2483-2500
    • Zeineh, M.M.1    Chen, Y.2    Kitzler, H.H.3    Hammond, R.4    Vogel, H.5    Rutt, B.K.6
  • 15
    • 79960338851 scopus 로고    scopus 로고
    • Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia
    • N. Mairuae J. R. Connor P. Cheepsunthorn Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia Neurosci. Lett. 2011 500 1 36 40
    • (2011) Neurosci. Lett. , vol.500 , Issue.1 , pp. 36-40
    • Mairuae, N.1    Connor, J.R.2    Cheepsunthorn, P.3
  • 16
    • 84908028367 scopus 로고    scopus 로고
    • TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord
    • A. Kroner A. D. Greenhalgh J. G. Zarruk R. Passos Dos Santos M. Gaestel S. David TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord Neuron 2014 83 5 1098 1116
    • (2014) Neuron , vol.83 , Issue.5 , pp. 1098-1116
    • Kroner, A.1    Greenhalgh, A.D.2    Zarruk, J.G.3    Passos Dos Santos, R.4    Gaestel, M.5    David, S.6
  • 17
    • 66149090377 scopus 로고    scopus 로고
    • MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
    • M. D. Meadowcroft J. R. Connor M. B. Smith Q. X. Yang MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice J. Magn. Reson. Imaging 2009 29 5 997 1007
    • (2009) J. Magn. Reson. Imaging , vol.29 , Issue.5 , pp. 997-1007
    • Meadowcroft, M.D.1    Connor, J.R.2    Smith, M.B.3    Yang, Q.X.4
  • 18
    • 84924072485 scopus 로고    scopus 로고
    • The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease
    • M. D. Meadowcroft D. G. Peters R. P. Dewal J. R. Connor Q. X. Yang The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease NMR Biomed. 2015 28 3 297 305
    • (2015) NMR Biomed. , vol.28 , Issue.3 , pp. 297-305
    • Meadowcroft, M.D.1    Peters, D.G.2    Dewal, R.P.3    Connor, J.R.4    Yang, Q.X.5
  • 19
    • 84899647552 scopus 로고    scopus 로고
    • Single App knock-in mouse models of Alzheimer's disease
    • T. Saito Y. Matsuba N. Mihira et al., Single App knock-in mouse models of Alzheimer's disease Nat. Neurosci. 2014 17 5 661 663
    • (2014) Nat. Neurosci. , vol.17 , Issue.5 , pp. 661-663
    • Saito, T.1    Matsuba, Y.2    Mihira, N.3
  • 21
    • 0027473840 scopus 로고
    • Metabolism of iron from (3,5,5-trimethylhexanoyl)ferrocene in rats. A dietary model for severe iron overload
    • P. Nielsen H. C. Heinrich Metabolism of iron from (3,5,5-trimethylhexanoyl)ferrocene in rats. A dietary model for severe iron overload Biochem. Pharmacol. 1993 45 2 385 391
    • (1993) Biochem. Pharmacol. , vol.45 , Issue.2 , pp. 385-391
    • Nielsen, P.1    Heinrich, H.C.2
  • 22
    • 85009275008 scopus 로고    scopus 로고
    • Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue: Application in the APP/PS1 Mouse Model of Alzheimer's Disease
    • S. A. Sands R. Leung-Toung Y. Wang J. Connelly S. M. LeVine Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue: Application in the APP/PS1 Mouse Model of Alzheimer's Disease ASN Neuro 2016 8 5 10.1177/1759091416670978
    • (2016) ASN Neuro , vol.8 , Issue.5
    • Sands, S.A.1    Leung-Toung, R.2    Wang, Y.3    Connelly, J.4    LeVine, S.M.5
  • 23
    • 85029176800 scopus 로고    scopus 로고
    • Brain Metal Distribution and Neuro-Inflammatory Profiles after Chronic Vanadium Administration and Withdrawal in Mice
    • O. R. Folarin A. M. Snyder D. G. Peters F. Olopade J. R. Connor J. O. Olopade Brain Metal Distribution and Neuro-Inflammatory Profiles after Chronic Vanadium Administration and Withdrawal in Mice Front. Neuroanat. 2017 11 58
    • (2017) Front. Neuroanat. , vol.11 , pp. 58
    • Folarin, O.R.1    Snyder, A.M.2    Peters, D.G.3    Olopade, F.4    Connor, J.R.5    Olopade, J.O.6
  • 24
    • 78149277744 scopus 로고    scopus 로고
    • Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain
    • D. J. Hare J. L. George R. Grimm et al., Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain Metallomics 2010 2 11 745 753
    • (2010) Metallomics , vol.2 , Issue.11 , pp. 745-753
    • Hare, D.J.1    George, J.L.2    Grimm, R.3
  • 25
    • 84860432518 scopus 로고    scopus 로고
    • Three-dimensional atlas of iron, copper, and zinc in the mouse cerebrum and brainstem
    • D. J. Hare J. K. Lee A. D. Beavis et al., Three-dimensional atlas of iron, copper, and zinc in the mouse cerebrum and brainstem Anal. Chem. 2012 84 9 3990 3997
    • (2012) Anal. Chem. , vol.84 , Issue.9 , pp. 3990-3997
    • Hare, D.J.1    Lee, J.K.2    Beavis, A.D.3
  • 26
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ: 25 years of image analysis
    • C. A. Schneider W. S. Rasband K. W. Eliceiri NIH Image to ImageJ: 25 years of image analysis Nat. Methods 2012 9 7 671 675
    • (2012) Nat. Methods , vol.9 , Issue.7 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3
  • 27
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • E. S. Lein M. J. Hawrylycz N. Ao et al., Genome-wide atlas of gene expression in the adult mouse brain Nature 2007 445 7124 168 176
    • (2007) Nature , vol.445 , Issue.7124 , pp. 168-176
    • Lein, E.S.1    Hawrylycz, M.J.2    Ao, N.3
  • 29
    • 33644544412 scopus 로고    scopus 로고
    • Calcium, potassium, iron, copper and zinc concentrations in the white and gray matter of the cerebellum and corpus callosum in brain of four genetic mouse strains
    • C. Sergeant M. H. Vesvres G. Devès F. Guillou Calcium, potassium, iron, copper and zinc concentrations in the white and gray matter of the cerebellum and corpus callosum in brain of four genetic mouse strains Nucl. Instrum. Methods Phys. Res., Sect. B 2005 231 1-4 234 238
    • (2005) Nucl. Instrum. Methods Phys. Res., Sect. B , vol.231 , Issue.14 , pp. 234-238
    • Sergeant, C.1    Vesvres, M.H.2    Devès, G.3    Guillou, F.4
  • 30
    • 84873749490 scopus 로고    scopus 로고
    • Quantitative analysis of histological staining and fluorescence using ImageJ
    • E. C. Jensen Quantitative analysis of histological staining and fluorescence using ImageJ Anat. Rec. 2013 296 3 378 381
    • (2013) Anat. Rec. , vol.296 , Issue.3 , pp. 378-381
    • Jensen, E.C.1
  • 31
    • 85044191575 scopus 로고    scopus 로고
    • Two Ways to Count Cells with ImageJ, 2017
    • C. Labno, Two Ways to Count Cells with ImageJ, 2017, https://digital.bsd.uchicago.edu/docs/cell-counting-automated-and-manual.pdf
    • Labno, C.1
  • 32
    • 85019228637 scopus 로고    scopus 로고
    • Characterizing microglia activation: A spatial statistics approach to maximize information extraction
    • B. M. Davis M. Salinas-Navarro M. F. Cordeiro L. Moons L. De Groef Characterizing microglia activation: a spatial statistics approach to maximize information extraction Sci. Rep. 2017 7 1 1576
    • (2017) Sci. Rep. , vol.7 , Issue.1 , pp. 1576
    • Davis, B.M.1    Salinas-Navarro, M.2    Cordeiro, M.F.3    Moons, L.4    De Groef, L.5
  • 33
    • 84872149088 scopus 로고    scopus 로고
    • A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
    • H. W. Morrison J. A. Filosa A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion J. Neuroinflammation 2013 10 4
    • (2013) J. Neuroinflammation , vol.10 , pp. 4
    • Morrison, H.W.1    Filosa, J.A.2
  • 34
    • 84973535647 scopus 로고    scopus 로고
    • Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex
    • D. J. Hare E. P. Raven B. R. Roberts et al., Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex Neuroimage 2016 137 124 131
    • (2016) Neuroimage , vol.137 , pp. 124-131
    • Hare, D.J.1    Raven, E.P.2    Roberts, B.R.3
  • 35
    • 85028318324 scopus 로고    scopus 로고
    • Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline
    • S. Ayton A. Fazlollahi P. Bourgeat et al., Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline Brain 2017 140 8 2112 2119
    • (2017) Brain , vol.140 , Issue.8 , pp. 2112-2119
    • Ayton, S.1    Fazlollahi, A.2    Bourgeat, P.3
  • 36
    • 84992111252 scopus 로고    scopus 로고
    • Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment
    • J. M. van Bergen X. Li J. Hua et al., Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment Sci. Rep. 2016 6 35514
    • (2016) Sci. Rep. , vol.6 , pp. 35514
    • Van Bergen, J.M.1    Li, X.2    Hua, J.3
  • 37
    • 84866048404 scopus 로고    scopus 로고
    • Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington's disease
    • M. Di Paola E. Luders A. Cherubini et al., Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington's disease Cereb. Cortex 2012 22 12 2858 2866
    • (2012) Cereb. Cortex , vol.22 , Issue.12 , pp. 2858-2866
    • Di Paola, M.1    Luders, E.2    Cherubini, A.3
  • 38
    • 78951481093 scopus 로고    scopus 로고
    • Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease
    • A. C. Leskovjan A. Kretlow A. Lanzirotti R. Barrea S. Vogt L. M. Miller Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease NeuroImage 2011 55 1 32 38
    • (2011) NeuroImage , vol.55 , Issue.1 , pp. 32-38
    • Leskovjan, A.C.1    Kretlow, A.2    Lanzirotti, A.3    Barrea, R.4    Vogt, S.5    Miller, L.M.6
  • 39
    • 85027528978 scopus 로고    scopus 로고
    • TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease
    • T. K. Ulland W. M. Song S. C. Huang et al., TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease Cell 2017 170 4 649 663
    • (2017) Cell , vol.170 , Issue.4 , pp. 649-663
    • Ulland, T.K.1    Song, W.M.2    Huang, S.C.3
  • 40
    • 85028725970 scopus 로고    scopus 로고
    • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
    • R. Sims S. J. van der Lee A. C. Naj et al., Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Nat. Genet. 2017 49 9 1373 1384
    • (2017) Nat. Genet. , vol.49 , Issue.9 , pp. 1373-1384
    • Sims, R.1    Van Der Lee, S.J.2    Naj, A.C.3
  • 41
    • 85038031894 scopus 로고    scopus 로고
    • Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
    • K. A. Clayton A. A. Van Enoo T. Ikezu Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy Front. Neurosci. 2017 11 680
    • (2017) Front. Neurosci. , vol.11 , pp. 680
    • Clayton, K.A.1    Van Enoo, A.A.2    Ikezu, T.3
  • 42
    • 84994323479 scopus 로고    scopus 로고
    • Significant glial alterations in response to iron loading in a novel organotypic hippocampal slice culture model
    • S. Healy J. McMahon P. Owens U. FitzGerald Significant glial alterations in response to iron loading in a novel organotypic hippocampal slice culture model Sci. Rep. 2016 6 36410
    • (2016) Sci. Rep. , vol.6 , pp. 36410
    • Healy, S.1    McMahon, J.2    Owens, P.3    FitzGerald, U.4
  • 43
    • 85018216701 scopus 로고    scopus 로고
    • Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging
    • A. D. Bachstetter L. J. Van Eldik F. A. Schmitt et al., Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging Acta Neuropathol. Commun. 2015 3 32
    • (2015) Acta Neuropathol. Commun. , vol.3 , pp. 32
    • Bachstetter, A.D.1    Van Eldik, L.J.2    Schmitt, F.A.3
  • 44
    • 85008263113 scopus 로고    scopus 로고
    • Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease
    • D. S. Davies J. Ma T. Jegathees C. Goldsbury Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease Brain Pathol. 2017 27 6 795 808
    • (2017) Brain Pathol. , vol.27 , Issue.6 , pp. 795-808
    • Davies, D.S.1    Ma, J.2    Jegathees, T.3    Goldsbury, C.4
  • 45
    • 84871958441 scopus 로고    scopus 로고
    • Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
    • C. Guo P. Wang M. L. Zhong et al., Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain Neurochem. Int. 2013 62 2 165 172
    • (2013) Neurochem. Int. , vol.62 , Issue.2 , pp. 165-172
    • Guo, C.1    Wang, P.2    Zhong, M.L.3
  • 46
    • 84903818809 scopus 로고    scopus 로고
    • Iron overload accelerates neuronal amyloid-beta production and cognitive impairment in transgenic mice model of Alzheimer's disease
    • J. Becerril-Ortega K. Bordji T. Freret T. Rush A. Buisson Iron overload accelerates neuronal amyloid-beta production and cognitive impairment in transgenic mice model of Alzheimer's disease Neurobiol. Aging 2014 35 10 2288 2301
    • (2014) Neurobiol. Aging , vol.35 , Issue.10 , pp. 2288-2301
    • Becerril-Ortega, J.1    Bordji, K.2    Freret, T.3    Rush, T.4    Buisson, A.5
  • 47
    • 84978715654 scopus 로고    scopus 로고
    • A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-beta accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload
    • J. Sripetchwandee S. Wongjaikam W. Krintratun N. Chattipakorn S. C. Chattipakorn A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-beta accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload Neuroscience 2016 332 191 202
    • (2016) Neuroscience , vol.332 , pp. 191-202
    • Sripetchwandee, J.1    Wongjaikam, S.2    Krintratun, W.3    Chattipakorn, N.4    Chattipakorn, S.C.5
  • 48
    • 0028873173 scopus 로고
    • Iron levels modulate alpha-secretase cleavage of amyloid precursor protein
    • S. Bodovitz M. T. Falduto D. E. Frail W. L. Klein Iron levels modulate alpha-secretase cleavage of amyloid precursor protein J. Neurochem. 1995 64 1 307 315
    • (1995) J. Neurochem. , vol.64 , Issue.1 , pp. 307-315
    • Bodovitz, S.1    Falduto, M.T.2    Frail, D.E.3    Klein, W.L.4
  • 49
    • 84880137264 scopus 로고    scopus 로고
    • Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity
    • X. Li Y. Liu Q. Zheng et al., Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity Neurosci. Lett. 2013 548 90 94
    • (2013) Neurosci. Lett. , vol.548 , pp. 90-94
    • Li, X.1    Liu, Y.2    Zheng, Q.3
  • 50
    • 85030841047 scopus 로고    scopus 로고
    • Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease
    • N. D. Telling J. Everett J. F. Collingwood et al., Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease Cell Chem. Biol. 2017 24 10 1205 1215
    • (2017) Cell Chem. Biol. , vol.24 , Issue.10 , pp. 1205-1215
    • Telling, N.D.1    Everett, J.2    Collingwood, J.F.3
  • 51
    • 84872330749 scopus 로고    scopus 로고
    • Interplay between alpha-, beta-, and gamma-secretases determines biphasic amyloid-beta protein level in the presence of a gamma-secretase inhibitor
    • F. Ortega J. Stott S. A. Visser C. Bendtsen Interplay between alpha-, beta-, and gamma-secretases determines biphasic amyloid-beta protein level in the presence of a gamma-secretase inhibitor J. Biol. Chem. 2013 288 2 785 792
    • (2013) J. Biol. Chem. , vol.288 , Issue.2 , pp. 785-792
    • Ortega, F.1    Stott, J.2    Visser, S.A.3    Bendtsen, C.4
  • 52
    • 84880572550 scopus 로고    scopus 로고
    • Alzheimer's Abeta42 and Abeta40 peptides form interlaced amyloid fibrils
    • L. Gu Z. Guo Alzheimer's Abeta42 and Abeta40 peptides form interlaced amyloid fibrils J. Neurochem. 2013 126 3 305 311
    • (2013) J. Neurochem. , vol.126 , Issue.3 , pp. 305-311
    • Gu, L.1    Guo, Z.2
  • 53
    • 84857321482 scopus 로고    scopus 로고
    • Structural basis for increased toxicity of pathologicalabeta42: Abeta40 ratios in Alzheimer disease
    • K. Pauwels T. L. Williams K. L. Morris et al., Structural basis for increased toxicity of pathologicalabeta42: abeta40 ratios in Alzheimer disease J. Biol. Chem. 2012 287 8 5650 5660
    • (2012) J. Biol. Chem. , vol.287 , Issue.8 , pp. 5650-5660
    • Pauwels, K.1    Williams, T.L.2    Morris, K.L.3
  • 54
    • 84977156478 scopus 로고    scopus 로고
    • Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
    • M. Iljina G. A. Garcia A. J. Dear et al., Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms Sci. Rep. 2016 6 28658
    • (2016) Sci. Rep. , vol.6 , pp. 28658
    • Iljina, M.1    Garcia, G.A.2    Dear, A.J.3
  • 56
    • 17944368176 scopus 로고    scopus 로고
    • the 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
    • C. Nilsberth A. Westlind-Danielsson C. B. Eckman et al., The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation Nat. Neurosci. 2001 4 9 887 893
    • (2001) Nat. Neurosci. , vol.4 , Issue.9 , pp. 887-893
    • Nilsberth, C.1    Westlind-Danielsson, A.2    Eckman, C.B.3
  • 57
    • 84875082623 scopus 로고    scopus 로고
    • A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice
    • W. Nandar E. B. Neely E. Unger J. R. Connor A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice Biochim. Biophys. Acta 2013 1832 6 729 741
    • (2013) Biochim. Biophys. Acta , vol.1832 , Issue.6 , pp. 729-741
    • Nandar, W.1    Neely, E.B.2    Unger, E.3    Connor, J.R.4
  • 58
    • 84864874844 scopus 로고    scopus 로고
    • Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer's disease patients
    • M. Padurariu A. Ciobica I. Mavroudis D. Fotiou S. Baloyannis Hippocampal neuronal loss in the CA1 and CA3 areas of Alzheimer's disease patients Psychiatr. Danubina 2012 24 2 152 158
    • (2012) Psychiatr. Danubina , vol.24 , Issue.2 , pp. 152-158
    • Padurariu, M.1    Ciobica, A.2    Mavroudis, I.3    Fotiou, D.4    Baloyannis, S.5
  • 59
    • 0032911278 scopus 로고    scopus 로고
    • Metabolism of 3,5,5-trimethylhexanoyl-ferrocene by rat liver: Release of iron from 3,5,5-trimethylhexanoyl-ferrocene by a microsomal, phenobarbital-inducible cytochrome P-450
    • E. E. Cable H. C. Isom Metabolism of 3,5,5-trimethylhexanoyl-ferrocene by rat liver: release of iron from 3,5,5-trimethylhexanoyl-ferrocene by a microsomal, phenobarbital-inducible cytochrome P-450 Drug Metab. Dispos. 1999 27 2 255 260
    • (1999) Drug Metab. Dispos. , vol.27 , Issue.2 , pp. 255-260
    • Cable, E.E.1    Isom, H.C.2
  • 60
    • 84891786002 scopus 로고    scopus 로고
    • Cytochrome p450 mRNA expression in the rodent brain: Species-, sex-, and region-dependent differences
    • M. Stamou X. Wu I. Kania-Korwel H. J. Lehmler P. J. Lein Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences Drug Metab. Dispos. 2014 42 2 239 244
    • (2014) Drug Metab. Dispos. , vol.42 , Issue.2 , pp. 239-244
    • Stamou, M.1    Wu, X.2    Kania-Korwel, I.3    Lehmler, H.J.4    Lein, P.J.5
  • 61
    • 84873378490 scopus 로고    scopus 로고
    • Kinetic studies of inhibition of the amyloid beta (1-42) aggregation using a ferrocene-tagged beta-sheet breaker peptide
    • L. Zhang G. Yagnik Y. Peng et al., Kinetic studies of inhibition of the amyloid beta (1-42) aggregation using a ferrocene-tagged beta-sheet breaker peptide Anal. Biochem. 2013 434 2 292 299
    • (2013) Anal. Biochem. , vol.434 , Issue.2 , pp. 292-299
    • Zhang, L.1    Yagnik, G.2    Peng, Y.3
  • 62
    • 84947969627 scopus 로고    scopus 로고
    • Oral iron acutely elevates bacterial growth in human serum
    • J. H. Cross R. S. Bradbury A. J. Fulford et al., Oral iron acutely elevates bacterial growth in human serum Sci. Rep. 2015 5 16670
    • (2015) Sci. Rep. , vol.5 , pp. 16670
    • Cross, J.H.1    Bradbury, R.S.2    Fulford, A.J.3
  • 63
    • 85020476769 scopus 로고    scopus 로고
    • Altered peripheral profile of blood cells in Alzheimer disease: A hospital-based case-control study
    • S. H. Chen X. L. Bu W. S. Jin et al., Altered peripheral profile of blood cells in Alzheimer disease: a hospital-based case-control study Medicine 2017 96 21 e6843
    • (2017) Medicine , vol.96 , Issue.21 , pp. e6843
    • Chen, S.H.1    Bu, X.L.2    Jin, W.S.3
  • 64
    • 84908897414 scopus 로고    scopus 로고
    • An anemia of Alzheimer's disease
    • N. G. Faux A. Rembach J. Wiley et al., An anemia of Alzheimer's disease Mol. Psychiatry 2014 19 11 1227 1234
    • (2014) Mol. Psychiatry , vol.19 , Issue.11 , pp. 1227-1234
    • Faux, N.G.1    Rembach, A.2    Wiley, J.3
  • 65
    • 84963738728 scopus 로고    scopus 로고
    • Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer's Dementia Using Quantitative Susceptibility Mapping Imaging
    • Y. Moon S. H. Han W. J. Moon Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer's Dementia Using Quantitative Susceptibility Mapping Imaging J. Alzheimer's Dis. 2016 51 3 737 745
    • (2016) J. Alzheimer's Dis. , vol.51 , Issue.3 , pp. 737-745
    • Moon, Y.1    Han, S.H.2    Moon, W.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.