메뉴 건너뛰기




Volumn 48, Issue 3, 2018, Pages 399-416

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; PROTEIN P53; BIOLOGICAL MARKER;

EID: 85043767157     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.03.004     Document Type: Review
Times cited : (443)

References (125)
  • 3
    • 34447506658 scopus 로고    scopus 로고
    • Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
    • Ancrile, B., Lim, K.H., Counter, C.M., Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21 (2007), 1714–1719.
    • (2007) Genes Dev. , vol.21 , pp. 1714-1719
    • Ancrile, B.1    Lim, K.H.2    Counter, C.M.3
  • 5
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • Balkwill, F., Mantovani, A., Inflammation and cancer: back to Virchow?. Lancet 357 (2001), 539–545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 6
    • 85020905525 scopus 로고    scopus 로고
    • Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer
    • Balli, D., Rech, A.J., Stanger, B.Z., Vonderheide, R.H., Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer. Clin. Cancer Res. 23 (2017), 3129–3138.
    • (2017) Clin. Cancer Res. , vol.23 , pp. 3129-3138
    • Balli, D.1    Rech, A.J.2    Stanger, B.Z.3    Vonderheide, R.H.4
  • 10
  • 11
    • 0002089736 scopus 로고
    • Zur Frage der Entstehung Maligner Tumoren
    • Boveri, T., Zur Frage der Entstehung Maligner Tumoren. Gustav Fischer 1914 (1914), 1–64.
    • (1914) Gustav Fischer , vol.1914 , pp. 1-64
    • Boveri, T.1
  • 15
    • 84964955489 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status
    • Cha, Y.J., Kim, H.R., Lee, C.Y., Cho, B.C., Shim, H.S., Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status. Lung Cancer 97 (2016), 73–80.
    • (2016) Lung Cancer , vol.97 , pp. 73-80
    • Cha, Y.J.1    Kim, H.R.2    Lee, C.Y.3    Cho, B.C.4    Shim, H.S.5
  • 16
    • 85009106590 scopus 로고    scopus 로고
    • Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
    • Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., Trajanoski, Z., Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade. Cell Rep. 18 (2017), 248–262.
    • (2017) Cell Rep. , vol.18 , pp. 248-262
    • Charoentong, P.1    Finotello, F.2    Angelova, M.3    Mayer, C.4    Efremova, M.5    Rieder, D.6    Hackl, H.7    Trajanoski, Z.8
  • 17
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: the cancer-immunity cycle
    • Chen, D.S., Mellman, I., Oncology meets immunology: the cancer-immunity cycle. Immunity 39 (2013), 1–10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 20
    • 80054789761 scopus 로고    scopus 로고
    • Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
    • Chien, Y., Scuoppo, C., Wang, X., Fang, X., Balgley, B., Bolden, J.E., Premsrirut, P., Luo, W., Chicas, A., Lee, C.S., et al. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev. 25 (2011), 2125–2136.
    • (2011) Genes Dev. , vol.25 , pp. 2125-2136
    • Chien, Y.1    Scuoppo, C.2    Wang, X.3    Fang, X.4    Balgley, B.5    Bolden, J.E.6    Premsrirut, P.7    Luo, W.8    Chicas, A.9    Lee, C.S.10
  • 23
    • 0000161413 scopus 로고
    • The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases
    • Coley, W.B., The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases. Am. J. Med. Sci. 105 (1893), 487–511.
    • (1893) Am. J. Med. Sci. , vol.105 , pp. 487-511
    • Coley, W.B.1
  • 25
    • 84905717306 scopus 로고    scopus 로고
    • Caught in the cross fire: p53 in inflammation
    • Cooks, T., Harris, C.C., Oren, M., Caught in the cross fire: p53 in inflammation. Carcinogenesis 35 (2014), 1680–1690.
    • (2014) Carcinogenesis , vol.35 , pp. 1680-1690
    • Cooks, T.1    Harris, C.C.2    Oren, M.3
  • 26
    • 85032489209 scopus 로고    scopus 로고
    • Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis
    • Debebe, A., Medina, V., Chen, C.Y., Mahajan, I.M., Jia, C., Fu, D., He, L., Zeng, N., Stiles, B.W., Chen, C.L., et al. Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene 36 (2017), 6020–6029.
    • (2017) Oncogene , vol.36 , pp. 6020-6029
    • Debebe, A.1    Medina, V.2    Chen, C.Y.3    Mahajan, I.M.4    Jia, C.5    Fu, D.6    He, L.7    Zeng, N.8    Stiles, B.W.9    Chen, C.L.10
  • 30
  • 34
    • 0014906806 scopus 로고
    • Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses
    • Duesberg, P.H., Vogt, P.K., Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses. Proc. Natl. Acad. Sci. USA 67 (1970), 1673–1680.
    • (1970) Proc. Natl. Acad. Sci. USA , vol.67 , pp. 1673-1680
    • Duesberg, P.H.1    Vogt, P.K.2
  • 36
    • 0035893318 scopus 로고    scopus 로고
    • Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
    • Fisher, G.H., Wellen, S.L., Klimstra, D., Lenczowski, J.M., Tichelaar, J.W., Lizak, M.J., Whitsett, J.A., Koretsky, A., Varmus, H.E., Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15 (2001), 3249–3262.
    • (2001) Genes Dev. , vol.15 , pp. 3249-3262
    • Fisher, G.H.1    Wellen, S.L.2    Klimstra, D.3    Lenczowski, J.M.4    Tichelaar, J.W.5    Lizak, M.J.6    Whitsett, J.A.7    Koretsky, A.8    Varmus, H.E.9
  • 37
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick, D.T., Piris, A., Cogdill, A.P., Cooper, Z.A., Lezcano, C., Ferrone, C.R., Mitra, D., Boni, A., Newton, L.P., Liu, C., et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin. Cancer Res. 19 (2013), 1225–1231.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3    Cooper, Z.A.4    Lezcano, C.5    Ferrone, C.R.6    Mitra, D.7    Boni, A.8    Newton, L.P.9    Liu, C.10
  • 42
    • 84913536390 scopus 로고    scopus 로고
    • Drug resistance to targeted therapies: déjà vu all over again
    • Groenendijk, F.H., Bernards, R., Drug resistance to targeted therapies: déjà vu all over again. Mol. Oncol. 8 (2014), 1067–1083.
    • (2014) Mol. Oncol. , vol.8 , pp. 1067-1083
    • Groenendijk, F.H.1    Bernards, R.2
  • 44
    • 34548860125 scopus 로고    scopus 로고
    • The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer
    • Hanahan, D., Wagner, E.F., Palmiter, R.D., The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer. Genes Dev. 21 (2007), 2258–2270.
    • (2007) Genes Dev. , vol.21 , pp. 2258-2270
    • Hanahan, D.1    Wagner, E.F.2    Palmiter, R.D.3
  • 49
    • 85027880632 scopus 로고    scopus 로고
    • Generating Genetically Modified Mice: A Decision Guide
    • Huijbers, I.J., Generating Genetically Modified Mice: A Decision Guide. Methods Mol. Biol. 1642 (2017), 1–19.
    • (2017) Methods Mol. Biol. , vol.1642 , pp. 1-19
    • Huijbers, I.J.1
  • 52
    • 84945198502 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of FOXP3+ tumor infiltrating lymphocytes in patients with breast cancer: a meta-analysis
    • Jiang, D., Gao, Z., Cai, Z., Wang, M., He, J., Clinicopathological and prognostic significance of FOXP3+ tumor infiltrating lymphocytes in patients with breast cancer: a meta-analysis. BMC Cancer, 15, 2015, 727.
    • (2015) BMC Cancer , vol.15 , pp. 727
    • Jiang, D.1    Gao, Z.2    Cai, Z.3    Wang, M.4    He, J.5
  • 55
    • 85028938348 scopus 로고    scopus 로고
    • Putting p53 in Context
    • Kastenhuber, E.R., Lowe, S.W., Putting p53 in Context. Cell 170 (2017), 1062–1078.
    • (2017) Cell , vol.170 , pp. 1062-1078
    • Kastenhuber, E.R.1    Lowe, S.W.2
  • 58
    • 85008489691 scopus 로고    scopus 로고
    • Genetically engineered mouse models in oncology research and cancer medicine
    • Kersten, K., de Visser, K.E., van Miltenburg, M.H., Jonkers, J., Genetically engineered mouse models in oncology research and cancer medicine. EMBO Mol. Med. 9 (2017), 137–153.
    • (2017) EMBO Mol. Med. , vol.9 , pp. 137-153
    • Kersten, K.1    de Visser, K.E.2    van Miltenburg, M.H.3    Jonkers, J.4
  • 59
    • 0015043748 scopus 로고
    • Mutation and cancer: statistical study of retinoblastoma
    • Knudson, A.G. Jr., Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68 (1971), 820–823.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 60
    • 33144490246 scopus 로고    scopus 로고
    • Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin
    • Kobielak, A., Fuchs, E., Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin. Proc. Natl. Acad. Sci. USA 103 (2006), 2322–2327.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 2322-2327
    • Kobielak, A.1    Fuchs, E.2
  • 63
    • 84961858396 scopus 로고    scopus 로고
    • STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment
    • Koyama, S., Akbay, E.A., Li, Y.Y., Aref, A.R., Skoulidis, F., Herter-Sprie, G.S., Buczkowski, K.A., Liu, Y., Awad, M.M., Denning, W.L., et al. STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment. Cancer Res. 76 (2016), 999–1008.
    • (2016) Cancer Res. , vol.76 , pp. 999-1008
    • Koyama, S.1    Akbay, E.A.2    Li, Y.Y.3    Aref, A.R.4    Skoulidis, F.5    Herter-Sprie, G.S.6    Buczkowski, K.A.7    Liu, Y.8    Awad, M.M.9    Denning, W.L.10
  • 72
    • 84864828790 scopus 로고    scopus 로고
    • The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
    • Medrek, C., Pontén, F., Jirström, K., Leandersson, K., The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer, 12, 2012, 306.
    • (2012) BMC Cancer , vol.12 , pp. 306
    • Medrek, C.1    Pontén, F.2    Jirström, K.3    Leandersson, K.4
  • 73
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma
    • Meylan, E., Dooley, A.L., Feldser, D.M., Shen, L., Turk, E., Ouyang, C., Jacks, T., Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462 (2009), 104–107.
    • (2009) Nature , vol.462 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3    Shen, L.4    Turk, E.5    Ouyang, C.6    Jacks, T.7
  • 75
    • 84896098750 scopus 로고    scopus 로고
    • Mutant p53 in cancer: new functions and therapeutic opportunities
    • Muller, P.A., Vousden, K.H., Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell 25 (2014), 304–317.
    • (2014) Cancer Cell , vol.25 , pp. 304-317
    • Muller, P.A.1    Vousden, K.H.2
  • 76
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: from physiology to pathology
    • Muñoz-Espín, D., Serrano, M., Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15 (2014), 482–496.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 482-496
    • Muñoz-Espín, D.1    Serrano, M.2
  • 77
    • 84988735450 scopus 로고    scopus 로고
    • Emerging roles of p53 and other tumour-suppressor genes in immune regulation
    • Muñoz-Fontela, C., Mandinova, A., Aaronson, S.A., Lee, S.W., Emerging roles of p53 and other tumour-suppressor genes in immune regulation. Nat. Rev. Immunol. 16 (2016), 741–750.
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 741-750
    • Muñoz-Fontela, C.1    Mandinova, A.2    Aaronson, S.A.3    Lee, S.W.4
  • 81
    • 84904990966 scopus 로고    scopus 로고
    • Inside and out: the activities of senescence in cancer
    • Pérez-Mancera, P.A., Young, A.R., Narita, M., Inside and out: the activities of senescence in cancer. Nat. Rev. Cancer 14 (2014), 547–558.
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 547-558
    • Pérez-Mancera, P.A.1    Young, A.R.2    Narita, M.3
  • 83
    • 84862147254 scopus 로고    scopus 로고
    • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
    • Pylayeva-Gupta, Y., Lee, K.E., Hajdu, C.H., Miller, G., Bar-Sagi, D., Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21 (2012), 836–847.
    • (2012) Cancer Cell , vol.21 , pp. 836-847
    • Pylayeva-Gupta, Y.1    Lee, K.E.2    Hajdu, C.H.3    Miller, G.4    Bar-Sagi, D.5
  • 85
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi, N.A., Hellmann, M.D., Snyder, A., Kvistborg, P., Makarov, V., Havel, J.J., Lee, W., Yuan, J., Wong, P., Ho, T.S., et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348 (2015), 124–128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6    Lee, W.7    Yuan, J.8    Wong, P.9    Ho, T.S.10
  • 86
    • 84880276438 scopus 로고    scopus 로고
    • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
    • Robbins, P.F., Lu, Y.C., El-Gamil, M., Li, Y.F., Gross, C., Gartner, J., Lin, J.C., Teer, J.K., Cliften, P., Tycksen, E., et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nat. Med. 19 (2013), 747–752.
    • (2013) Nat. Med. , vol.19 , pp. 747-752
    • Robbins, P.F.1    Lu, Y.C.2    El-Gamil, M.3    Li, Y.F.4    Gross, C.5    Gartner, J.6    Lin, J.C.7    Teer, J.K.8    Cliften, P.9    Tycksen, E.10
  • 88
    • 84920962202 scopus 로고    scopus 로고
    • Molecular and genetic properties of tumors associated with local immune cytolytic activity
    • Rooney, M.S., Shukla, S.A., Wu, C.J., Getz, G., Hacohen, N., Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 160 (2015), 48–61.
    • (2015) Cell , vol.160 , pp. 48-61
    • Rooney, M.S.1    Shukla, S.A.2    Wu, C.J.3    Getz, G.4    Hacohen, N.5
  • 89
    • 84979948588 scopus 로고
    • A Sarcoma of the Fowl Transmissible by an Agent Separable from the Tumor Cells
    • Rous, P., A Sarcoma of the Fowl Transmissible by an Agent Separable from the Tumor Cells. J. Exp. Med. 13 (1911), 397–411.
    • (1911) J. Exp. Med. , vol.13 , pp. 397-411
    • Rous, P.1
  • 90
    • 84924033378 scopus 로고    scopus 로고
    • Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK
    • Sagiv-Barfi, I., Kohrt, H.E., Czerwinski, D.K., Ng, P.P., Chang, B.Y., Levy, R., Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. Proc. Natl. Acad. Sci. USA 112 (2015), E966–E972.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. E966-E972
    • Sagiv-Barfi, I.1    Kohrt, H.E.2    Czerwinski, D.K.3    Ng, P.P.4    Chang, B.Y.5    Levy, R.6
  • 93
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher, T.N., Schreiber, R.D., Neoantigens in cancer immunotherapy. Science 348 (2015), 69–74.
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 94
    • 80055079998 scopus 로고    scopus 로고
    • The cooperating mutation or “second hit” determines the immunologic visibility toward MYC-induced murine lymphomas
    • Schuster, C., Berger, A., Hoelzl, M.A., Putz, E.M., Frenzel, A., Simma, O., Moritz, N., Hoelbl, A., Kovacic, B., Freissmuth, M., et al. The cooperating mutation or “second hit” determines the immunologic visibility toward MYC-induced murine lymphomas. Blood 118 (2011), 4635–4645.
    • (2011) Blood , vol.118 , pp. 4635-4645
    • Schuster, C.1    Berger, A.2    Hoelzl, M.A.3    Putz, E.M.4    Frenzel, A.5    Simma, O.6    Moritz, N.7    Hoelbl, A.8    Kovacic, B.9    Freissmuth, M.10
  • 95
  • 96
  • 100
    • 34948852371 scopus 로고    scopus 로고
    • Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
    • Soucek, L., Lawlor, E.R., Soto, D., Shchors, K., Swigart, L.B., Evan, G.I., Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat. Med. 13 (2007), 1211–1218.
    • (2007) Nat. Med. , vol.13 , pp. 1211-1218
    • Soucek, L.1    Lawlor, E.R.2    Soto, D.3    Shchors, K.4    Swigart, L.B.5    Evan, G.I.6
  • 101
    • 7944223098 scopus 로고    scopus 로고
    • Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
    • Sparmann, A., Bar-Sagi, D., Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 6 (2004), 447–458.
    • (2004) Cancer Cell , vol.6 , pp. 447-458
    • Sparmann, A.1    Bar-Sagi, D.2
  • 102
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
    • Spranger, S., Bao, R., Gajewski, T.F., Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature 523 (2015), 231–235.
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 103
    • 84999098073 scopus 로고    scopus 로고
    • Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma
    • Spranger, S., Luke, J.J., Bao, R., Zha, Y., Hernandez, K.M., Li, Y., Gajewski, A.P., Andrade, J., Gajewski, T.F., Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma. Proc. Natl. Acad. Sci. USA 113 (2016), E7759–E7768.
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. E7759-E7768
    • Spranger, S.1    Luke, J.J.2    Bao, R.3    Zha, Y.4    Hernandez, K.M.5    Li, Y.6    Gajewski, A.P.7    Andrade, J.8    Gajewski, T.F.9
  • 104
    • 85013841114 scopus 로고    scopus 로고
    • Variation in the Incidence and Magnitude of Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes: A Systematic Review
    • Stanton, S.E., Adams, S., Disis, M.L., Variation in the Incidence and Magnitude of Tumor-Infiltrating Lymphocytes in Breast Cancer Subtypes: A Systematic Review. JAMA Oncol. 2 (2016), 1354–1360.
    • (2016) JAMA Oncol. , vol.2 , pp. 1354-1360
    • Stanton, S.E.1    Adams, S.2    Disis, M.L.3
  • 105
    • 0017250977 scopus 로고
    • DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
    • Stehelin, D., Varmus, H.E., Bishop, J.M., Vogt, P.K., DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260 (1976), 170–173.
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 106
    • 0021720781 scopus 로고
    • Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
    • Stewart, T.A., Pattengale, P.K., Leder, P., Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 38 (1984), 627–637.
    • (1984) Cell , vol.38 , pp. 627-637
    • Stewart, T.A.1    Pattengale, P.K.2    Leder, P.3
  • 107
    • 84971009622 scopus 로고    scopus 로고
    • Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment
    • Stiff, A., Trikha, P., Wesolowski, R., Kendra, K., Hsu, V., Uppati, S., McMichael, E., Duggan, M., Campbell, A., Keller, K., et al. Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment. Cancer Res. 76 (2016), 2125–2136.
    • (2016) Cancer Res. , vol.76 , pp. 2125-2136
    • Stiff, A.1    Trikha, P.2    Wesolowski, R.3    Kendra, K.4    Hsu, V.5    Uppati, S.6    McMichael, E.7    Duggan, M.8    Campbell, A.9    Keller, K.10
  • 110
  • 113
    • 84905107708 scopus 로고    scopus 로고
    • Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
    • Vanden Borre, P., Gunda, V., McFadden, D.G., Sadow, P.M., Varmeh, S., Bernasconi, M., Parangi, S., Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer. Oncotarget 5 (2014), 3996–4010.
    • (2014) Oncotarget , vol.5 , pp. 3996-4010
    • Vanden Borre, P.1    Gunda, V.2    McFadden, D.G.3    Sadow, P.M.4    Varmeh, S.5    Bernasconi, M.6    Parangi, S.7
  • 115
    • 33646065584 scopus 로고
    • Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung
    • von Hansemann, D., Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung. Virchows Arch. Path. Anat 119 (1890), 299–326.
    • (1890) Virchows Arch. Path. Anat , vol.119 , pp. 299-326
    • von Hansemann, D.1
  • 117
    • 85027444208 scopus 로고    scopus 로고
    • Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment
    • Wang, Q., Hu, B., Hu, X., Kim, H., Squatrito, M., Scarpace, L., deCarvalho, A.C., Lyu, S., Li, P., Li, Y., et al. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell 32 (2017), 42–56 e46.
    • (2017) Cancer Cell , vol.32 , pp. 42-56 e46
    • Wang, Q.1    Hu, B.2    Hu, X.3    Kim, H.4    Squatrito, M.5    Scarpace, L.6    deCarvalho, A.C.7    Lyu, S.8    Li, P.9    Li, Y.10
  • 121
    • 84990026823 scopus 로고    scopus 로고
    • Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival
    • Wörmann, S.M., Song, L., Ai, J., Diakopoulos, K.N., Kurkowski, M.U., Görgülü K., Ruess, D., Campbell, A., Doglioni, C., Jodrell, D., et al. Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival. Gastroenterology 151 (2016), 180–193.e12.
    • (2016) Gastroenterology , vol.151 , pp. 180-193.e12
    • Wörmann, S.M.1    Song, L.2    Ai, J.3    Diakopoulos, K.N.4    Kurkowski, M.U.5    Görgülü, K.6    Ruess, D.7    Campbell, A.8    Doglioni, C.9    Jodrell, D.10
  • 123
    • 84941655113 scopus 로고    scopus 로고
    • Cancer immunotherapy: harnessing the immune system to battle cancer
    • Yang, Y., Cancer immunotherapy: harnessing the immune system to battle cancer. J. Clin. Invest. 125 (2015), 3335–3337.
    • (2015) J. Clin. Invest. , vol.125 , pp. 3335-3337
    • Yang, Y.1
  • 124
    • 84924275854 scopus 로고    scopus 로고
    • p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia
    • Yetil, A., Anchang, B., Gouw, A.M., Adam, S.J., Zabuawala, T., Parameswaran, R., van Riggelen, J., Plevritis, S., Felsher, D.W., p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia. Oncotarget 6 (2015), 3563–3577.
    • (2015) Oncotarget , vol.6 , pp. 3563-3577
    • Yetil, A.1    Anchang, B.2    Gouw, A.M.3    Adam, S.J.4    Zabuawala, T.5    Parameswaran, R.6    van Riggelen, J.7    Plevritis, S.8    Felsher, D.W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.