CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

Breast Cancer Research and Treatment

Volumn 130, Issue 2, 2011, Pages 645-655

  Liu, Fangfang ^a   Lang, Ronggang ^a   Zhao, Jing ^a   Zhang, Xinmin ^b   Pringle, Gordon A ^b   Fan, Yu ^a   Yin, Dong ^a   Gu, Feng ^a   Yao, Zhi ^a   Fu, Li ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

Breast carcinoma; Cytotoxic T cell; Molecular subtype; Regulatory T cell; Survival

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER CLASSIFICATION; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL DENSITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG TARGETING; FOXP3+ REGULATORY T LYMPHOCYTE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; REGULATORY T LYMPHOCYTE; TISSUE DISTRIBUTION;

EID: 85027940310     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1647-3     Document Type: Article

References (32)

1. Galon J, Costes A, Sanchez-Cabo F et al (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313:1960-1964 (Pubitemid 44498003)
2. Parmiani G (2005) Tumor-infiltrating T-cells\-friend or foe of neoplastic cells? N Engl J Med 353:2640-2641 (Pubitemid 41817712)
3. Chiou SH, Sheu BC, Chang WC, Huang SC, Ho HN (2005) Current concepts of tumor-infiltrating lymphocytes in human malignancies. J Reprod Immunol 67:35-50
4. Yu P, Fu YX (2006) Tumor-infiltrating T lymphocytes: friends or foes? Lab Invest 86:231-245 (Pubitemid 43276955)
5. Unitt E, Rushbrook SM, Marshall A et al (2005) Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology 41:722-730 (Pubitemid 40462933)
6. Guo XJ, Fan Y, Lang RG et al (2008) Tumor infiltrating lym-phocytes differ in invasive micropapillary carcinoma and med-ullary carcinoma ofbreast. Mod Pathol 21:1101-1107
7. Pages F, Berger A, Camus M et al (2005) Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med 353:2654-2666 (Pubitemid 41817714)
8. Zhang L, Conejo-Garcia JR, Katsaros D et al (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348:203-213 (Pubitemid 36077915)
9. Leong PP, Mohammad R, Ibrahim N et al (2006) Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast. Immunol Lett 102:229-236 (Pubitemid 43053092)
10. Baxevanis CN, Dedoussis GV, Papadopoulos NG, Missitzis I, Stathopoulos GP, Papamichail M (1994) Tumor specific cytolysis by tumor infiltrating lymphocytes in breast cancer. Cancer 74:1275-1282 (Pubitemid 24301780)
11. Curiel TJ (2007) Tregs and rethinking cancer immunotherapy. J Clin Invest 117:1167-1174 (Pubitemid 46718401)
12. Zou W (2006) Regulatory T cells, tumour immunity and immu-notherapy. Nat Rev Immunol 6:295-307
13. Curiel TJ, Coukos G, Zou LH et al (2004) Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10:942-949 (Pubitemid 39273735)
14. Annunziato F, Cosmi L, Liotta F et al (2002) Phenotype, local-ization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med 196:379-387 (Pubitemid 34879113)
15. Xu L, Xu W, Jiang Z, Zhang F, Chu Y, Xiong S (2009) Depletion of CD4(+)CD25(high) regulatory T cells from tumor infiltrating lymphocytes predominantly induces Th1 type immune response in vivo which inhibits tumor growth in adoptive immunotherapy. Cancer Biol Ther 8:66-72
16. Sato E, Olson SH, Ahn J et al (2005) Intraepithelial CD8(+) tumor-infiltrating lymphocytes and a high CD8(+)/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 102:18538-18543 (Pubitemid 43011261)
17. Kobayashi N, Hiraoka N, Yamagami W et al (2007) FOXP3(+) regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 13:902-911 (Pubitemid 46340366)
18. Gao Q, Qiu SJ, Fan J et al (2007) Intratumoral balance ofregulatory and cytotoxic T cells is associated with prognosis ofhepatocellular carcinoma after resection. J Clin Oncol 25:2586-2593 (Pubitemid 47041232)
19. Hiraoka N, Onozato K, Kosuge T, Hirohashi S (2006) Prevalence of FOXP3(+) regulatory T cells increases during the progression ofpancreatic ductal adenocarcinorna and its premalignant lesions. Clin Cancer Res 12:5423-5434 (Pubitemid 44497257)
20. Alvaro T, Lejeune M, Salvado MT et al (2005) Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 11:1467-1473 (Pubitemid 40315228)
21. Dieu-Nosjean MC, Antoine M, Danel C et al (2008) Long-term survival for patients with non-small-cell lung cancer with intra-tumoral lymphoid structures. J Clin Oncol 26:4410-4417
22. Salama P, Phillips M, Grieu F et al (2009) Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 27:186-192
23. Bates GJ, Fox SB, Han C etal (2006) Quantification ofregulatory T cells enables the identification of high-risk breast cancer patients and those at risk oflate relapse. J Clin Oncol 24:5373-5380 (Pubitemid 46623168)
24. Bohling SD, Allison KH (2008) Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target. Mod Pathol 21:1527-1532
25. Gobert M, Treilleux I, Bendriss-Vermare N et al (2009) Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 69:2000-2009
26. Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histo-pathology 19:403-410
27. Cheang MC, Chia SK, Voduc D et al (2009) Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101:736-750
28. Voduc KD, Cheang MC, Tyldesley S, Gelmon K, Nielsen TO, Kennecke H (2010) Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol 28:1684-1691
29. Grabenbauer GG, Lahmer G, Distel L, Niedobitek G (2006) Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. Clin Cancer Res 12:3355-3360
30. Nakano O, Sato M, Naito Y et al (2001) Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 61:5132-5136 (Pubitemid 32681545)
31. La Rocca G, Anzalone R, Corrao S et al (2008) CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome. His-topathology 52:203-212
32. Matkowski R, Gisterek I, Halon A et al (2009) The prognostic role of tumor-infiltrating CD4 and CD8 T lymphocytes in breast cancer. Anticancer Res 29:2445-2451