메뉴 건너뛰기




Volumn 18, Issue 5, 2018, Pages 313-322

Using immunotherapy to boost the abscopal effect

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DRUG CARRIER; NANOPARTICLE; TUMOR MARKER;

EID: 85043495119     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc.2018.6     Document Type: Review
Times cited : (880)

References (112)
  • 1
    • 84942115373 scopus 로고    scopus 로고
    • Expanding global access to radiotherapy
    • Atun, R. et al. Expanding global access to radiotherapy. Lancet Oncol. 16, 1153-1186 (2015).
    • (2015) Lancet Oncol , vol.16 , pp. 1153-1186
    • Atun, R.1
  • 2
    • 84903825697 scopus 로고    scopus 로고
    • Targeted radiotherapy with gold nanoparticles: Current status and future perspectives
    • Ngwa, W. et al. Targeted radiotherapy with gold nanoparticles: current status and future perspectives. Nanomedicine 9, 1063-1082 (2014).
    • (2014) Nanomedicine , vol.9 , pp. 1063-1082
    • Ngwa, W.1
  • 3
    • 33745192610 scopus 로고    scopus 로고
    • Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage i or Stage III non-small-cell lung cancer
    • Chang, J. Y. et al. Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer. Int. J. Radiat. Oncol. 65, 1087-1096 (2006).
    • (2006) Int. J. Radiat. Oncol , vol.65 , pp. 1087-1096
    • Chang, J.Y.1
  • 4
    • 84962220195 scopus 로고    scopus 로고
    • Radiation oncology in the era of precision medicine
    • Baumann, M. et al. Radiation oncology in the era of precision medicine. Nat. Rev. Cancer 16, 234-249 (2016).
    • (2016) Nat. Rev. Cancer , vol.16 , pp. 234-249
    • Baumann, M.1
  • 5
    • 0013071190 scopus 로고
    • Whole body irradiation. Radiobiology or medicine?
    • Mole, R. H. Whole body irradiation . radiobiology or medicine? Br. J. Radiol. 26, 234-241 (1953).
    • (1953) Br. J. Radiol , vol.26 , pp. 234-241
    • Mole, R.H.1
  • 7
    • 85014090264 scopus 로고    scopus 로고
    • The abscopal effect of radiation therapy: What is it and how can we use it in breast cancer?
    • Hu, Z. I., McArthur, H. L. & Ho, A. Y. The abscopal effect of radiation therapy: what is it and how can we use it in breast cancer? Curr. Breast Cancer Rep. 9, 45-51 (2017).
    • (2017) Curr. Breast Cancer Rep , vol.9 , pp. 45-51
    • Hu, Z.I.1    McArthur, H.L.2    Ho, A.Y.3
  • 8
    • 84912558665 scopus 로고    scopus 로고
    • Abscopal effects of radiation therapy: A clinical review for the radiobiologist
    • Siva, S., MacManus, M. P. & Martin, R. F. & Martin, O. A. Abscopal effects of radiation therapy: a clinical review for the radiobiologist. Cancer Lett. 356, 82-90 (2013).
    • (2013) Cancer Lett , vol.356 , pp. 82-90
    • Siva, S.1    MacManus, M.P.2    Martin, R.F.3    Martin, O.A.4
  • 9
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow, M. A. et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N. Engl. J. Med. 366, 925-931 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 925-931
    • Postow, M.A.1
  • 10
    • 33745106605 scopus 로고    scopus 로고
    • Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma
    • Wersall, P. J. et al. Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma. Acta Oncol. 45, 493-497 (2006).
    • (2006) Acta Oncol , vol.45 , pp. 493-497
    • Wersall, P.J.1
  • 11
    • 7344232177 scopus 로고    scopus 로고
    • Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis
    • Ohba, K. et al. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 43, 575-577 (1998).
    • (1998) Gut , vol.43 , pp. 575-577
    • Ohba, K.1
  • 12
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: A proof-of-principle trial
    • Golden, E. B. et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 16, 795-803 (2015).
    • (2015) Lancet Oncol , vol.16 , pp. 795-803
    • Golden, E.B.1
  • 13
    • 84961193536 scopus 로고    scopus 로고
    • Systematic review of case reports on the abscopal effect
    • Abuodeh, Y., Venkat, P. & Kim, S. Systematic review of case reports on the abscopal effect. Curr. Probl. Cancer 40, 25-37 (2016).
    • (2016) Curr. Probl. Cancer , vol.40 , pp. 25-37
    • Abuodeh, Y.1    Venkat, P.2    Kim, S.3
  • 14
    • 0016816906 scopus 로고
    • An interesting case of possible abscopal effect in malignant melanoma
    • Kingsley, D. P. An interesting case of possible abscopal effect in malignant melanoma. Br. J. Radiol 48, 863-866 (1975).
    • (1975) Br. J. Radiol , vol.48 , pp. 863-866
    • Kingsley, D.P.1
  • 15
    • 0015598767 scopus 로고
    • Abscopal effect of radiation in papillary adenocarcinoma
    • Ehlers, G. & Fridman, M. Abscopal effect of radiation in papillary adenocarcinoma. Br. J. Radiol. 46, 220-222 (1973).
    • (1973) Br. J. Radiol , vol.46 , pp. 220-222
    • Ehlers, G.1    Fridman, M.2
  • 16
    • 0018569985 scopus 로고
    • Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma
    • Stone, H. B., Peters, L. J. & Milas, L. Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. J. Natl Cancer Inst. 63, 1229-1235 (1979).
    • (1979) J. Natl Cancer Inst , vol.63 , pp. 1229-1235
    • Stone, H.B.1    Peters, L.J.2    Milas, L.3
  • 17
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • Demaria, S. et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int. J. Radiat. Oncol. Biol. Phys. 58, 862-870 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys , vol.58 , pp. 862-870
    • Demaria, S.1
  • 18
    • 0033572416 scopus 로고    scopus 로고
    • Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer
    • Chakravarty, P. K. et al. Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer. Cancer Res. 59, 6028-6032 (1999).
    • (1999) Cancer Res , vol.59 , pp. 6028-6032
    • Chakravarty, P.K.1
  • 19
    • 0345269096 scopus 로고    scopus 로고
    • Radiation abscopal antitumor effect is mediated through p53
    • Camphausen, K. et al. Radiation abscopal antitumor effect is mediated through p53. Cancer Res. 63, 1990-1993 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1990-1993
    • Camphausen, K.1
  • 20
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA.4 blockade in a mouse model of breast cancer
    • Demaria, S. et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA.4 blockade in a mouse model of breast cancer. Clin. Cancer Res. 11, 728-734 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 728-734
    • Demaria, S.1
  • 21
    • 38449092036 scopus 로고    scopus 로고
    • Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice
    • Akutsu, Y. et al. Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice. Int. J. Oncol. 31, 509-515 (2007).
    • (2007) Int. J. Oncol , vol.31 , pp. 509-515
    • Akutsu, Y.1
  • 22
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment
    • Lee, Y. et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 114, 589-595 (2009).
    • (2009) Blood , vol.114 , pp. 589-595
    • Lee, Y.1
  • 23
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA.4 antibody
    • Dewan, M. Z. et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA.4 antibody. Clin. Cancer Res. 15, 5379-5388 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1
  • 24
    • 0035892360 scopus 로고    scopus 로고
    • Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumorbearing mice: Approach to treatment of advanced stage cancer
    • Nikitina, E. Y. & Gabrilovich, D. I. Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumorbearing mice: approach to treatment of advanced stage cancer. Int. J. Cancer 94, 825-833 (2001).
    • (2001) Int. J. Cancer , vol.94 , pp. 825-833
    • Nikitina, E.Y.1    Gabrilovich, D.I.2
  • 25
    • 12144288198 scopus 로고    scopus 로고
    • Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity
    • Kim, K. W. et al. Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity. Int. J. Cancer 109, 685-690 (2004).
    • (2004) Int. J. Cancer , vol.109 , pp. 685-690
    • Kim, K.W.1
  • 26
    • 84926525215 scopus 로고    scopus 로고
    • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
    • Twyman-Saint Victor, C. et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520, 373-377 (2015).
    • (2015) Nature , vol.520 , pp. 373-377
    • Twyman-Saint Victor, C.1
  • 27
    • 84997810104 scopus 로고    scopus 로고
    • Current clinical trials testing the combination of immunotherapy with radiotherapy
    • Kang, J., Demaria, S. & Formenti, S. Current clinical trials testing the combination of immunotherapy with radiotherapy. J. Immunother. Cancer 4, 51 (2016).
    • (2016) J. Immunother. Cancer , vol.4 , pp. 51
    • Kang, J.1    Demaria, S.2    Formenti, S.3
  • 28
    • 84961175492 scopus 로고    scopus 로고
    • The immune mechanisms of abscopal effect in radiation therapy
    • Grass, G. D., Krishna, N. & Kim, S. The immune mechanisms of abscopal effect in radiation therapy. Curr. Probl. Cancer 40, 10-24 (2016).
    • (2016) Curr. Probl. Cancer , vol.40 , pp. 10-24
    • Grass, G.D.1    Krishna, N.2    Kim, S.3
  • 29
    • 84933050304 scopus 로고    scopus 로고
    • The tumour microenvironment after radiotherapy: Mechanisms of resistance and recurrence
    • Barker, H. E., Paget, J. T. E., Khan, A. A. & Harrington, K. J. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Cancer 15, 409-425 (2015).
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 409-425
    • Barker, H.E.1    Paget, J.T.E.2    Khan, A.A.3    Harrington, K.J.4
  • 31
    • 84894107349 scopus 로고    scopus 로고
    • New insights into cancer immunoediting and its three component phases-elimination, equilibrium and escape
    • Mittal, D., Gubin, M. M., Schreiber, R. D. & Smyth, M. J. New insights into cancer immunoediting and its three component phases-elimination, equilibrium and escape. Curr. Opin. Immunol. 27, 16-25 (2014).
    • (2014) Curr. Opin. Immunol , vol.27 , pp. 16-25
    • Mittal, D.1    Gubin, M.M.2    Schreiber, R.D.3    Smyth, M.J.4
  • 32
    • 84979277031 scopus 로고    scopus 로고
    • Fractionated radiotherapy with 3 8 Gy induces systemic anti-tumour responses and abscopal tumour inhibition without modulating the humoral anti-tumour response
    • Habets, T. H. et al. Fractionated radiotherapy with 3 8 Gy induces systemic anti-tumour responses and abscopal tumour inhibition without modulating the humoral anti-tumour response. PLoS ONE 11, e0159515 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0159515
    • Habets, T.H.1
  • 33
    • 85007189763 scopus 로고    scopus 로고
    • Enhancing radiotherapy for lung cancer using immunoadjuvants delivered in situ from new design radiotherapy biomaterials: A preclinical study
    • Hao, Y. et al. Enhancing radiotherapy for lung cancer using immunoadjuvants delivered in situ from new design radiotherapy biomaterials: a preclinical study. Phys. Med. Biol. 61, N697-N707 (2016).
    • (2016) Phys. Med. Biol , vol.61 , pp. N697-N707
    • Hao, Y.1
  • 34
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD.L1 treatment synergistically promote antitumor immunity in mice
    • Deng, L. et al. Irradiation and anti-PD.L1 treatment synergistically promote antitumor immunity in mice. J. Clin. Invest. 124, 687-695 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 687-695
    • Deng, L.1
  • 35
    • 85028019308 scopus 로고    scopus 로고
    • Brachytherapy attains abscopal effects when combined with immunostimulatory monoclonal antibodies
    • Rodriguez-Ruiz, M. E. et al. Brachytherapy attains abscopal effects when combined with immunostimulatory monoclonal antibodies. Brachytherapy 16, 1246-1251 (2017).
    • (2017) Brachytherapy , vol.16 , pp. 1246-1251
    • Rodriguez-Ruiz, M.E.1
  • 36
    • 84975524433 scopus 로고    scopus 로고
    • Optimizing timing of immunotherapy improves control of tumors by hypofractionated radiation therapy
    • Young, K. H. et al. Optimizing timing of immunotherapy improves control of tumors by hypofractionated radiation therapy. PLoS ONE 11, e0157164 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0157164
    • Young, K.H.1
  • 37
    • 84979277031 scopus 로고    scopus 로고
    • Fractionated radiotherapy with 3 8 Gy induces systemic anti-tumour responses and abscopal tumour inhibition without modulating the humoral anti-tumour response
    • Habets, T. H. P. M. et al. Fractionated radiotherapy with 3 8 Gy induces systemic anti-tumour responses and abscopal tumour inhibition without modulating the humoral anti-tumour response. PLoS ONE 11, e0159515 (2016).
    • (2016) PLoS ONE , vol.11 , pp. e0159515
    • Habets, T.H.P.M.1
  • 38
    • 79959246500 scopus 로고    scopus 로고
    • Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer
    • Yasuda, K., Nirei, T., Tsuno, N. H., Nagawa, H. & Kitayama, J. Intratumoral injection of interleukin-2 augments the local and abscopal effects of radiotherapy in murine rectal cancer. Cancer Sci. 102, 1257-1263 (2011).
    • (2011) Cancer Sci , vol.102 , pp. 1257-1263
    • Yasuda, K.1    Nirei, T.2    Tsuno, N.H.3    Nagawa, H.4    Kitayama, J.5
  • 39
    • 0345734266 scopus 로고    scopus 로고
    • Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration
    • Teitz-Tennenbaum, S. et al. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 63, 8466-8475 (2003).
    • (2003) Cancer Res , vol.63 , pp. 8466-8475
    • Teitz-Tennenbaum, S.1
  • 40
    • 84907546624 scopus 로고    scopus 로고
    • Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy
    • Kanegasaki, S., Matsushima, K., Shiraishi, K., Nakagawa, K. & Tsuchiya, T. Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy. Cancer Res. 74, 5070-5078 (2014).
    • (2014) Cancer Res , vol.74 , pp. 5070-5078
    • Kanegasaki, S.1    Matsushima, K.2    Shiraishi, K.3    Nakagawa, K.4    Tsuchiya, T.5
  • 41
    • 85013301355 scopus 로고    scopus 로고
    • A meta-analysis of the abscopal effect in preclinical models: Is the biologically effective dose a relevant physical trigger
    • Marconi, R. et al. A meta-analysis of the abscopal effect in preclinical models: is the biologically effective dose a relevant physical trigger? PLoS ONE 12, e0171559 (2017).
    • (2017) PLoS ONE , vol.12 , pp. e0171559
    • Marconi, R.1
  • 42
    • 39749126854 scopus 로고    scopus 로고
    • Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha
    • Shiraishi, K. et al. Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha. Clin. Cancer Res. 14, 1159-1166 (2008).
    • (2008) Clin. Cancer Res , vol.14 , pp. 1159-1166
    • Shiraishi, K.1
  • 43
    • 84942915875 scopus 로고    scopus 로고
    • Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions
    • Filatenkov, A. et al. Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions. Clin. Cancer Res. 21, 3727-3739 (2015).
    • (2015) Clin. Cancer Res , vol.21 , pp. 3727-3739
    • Filatenkov, A.1
  • 44
    • 84960158712 scopus 로고    scopus 로고
    • Immunotherapy and stereotactic ablative radiotherapy (ISABR): A curative approach?
    • Bernstein, M. B., Krishnan, S., Hodge, J. W. & Chang, J. Y. Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach? Nat. Rev. Clin. Oncol. 13, 516-524 (2016).
    • (2016) Nat. Rev. Clin. Oncol , vol.13 , pp. 516-524
    • Bernstein, M.B.1    Krishnan, S.2    Hodge, J.W.3    Chang, J.Y.4
  • 45
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson, D. B., Ko, J. S., Heidmann, T. & Medzhitov, R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134, 587-598 (2008).
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 46
    • 84999035231 scopus 로고    scopus 로고
    • MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
    • Wilson, R. et al. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat. Commun. 7, 13597 (2016).
    • (2016) Nat. Commun , vol.7 , pp. 13597
    • Wilson, R.1
  • 47
    • 85019727443 scopus 로고    scopus 로고
    • DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
    • Vanpouille-Box, C. et al. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat. Commun. 8, 15618 (2017).
    • (2017) Nat. Commun , vol.8 , pp. 15618
    • Vanpouille-Box, C.1
  • 48
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman, M. & Dranoff, G. Combining immunotherapy and targeted therapies in cancer treatment. Nat. Rev. Cancer 12, 237-251 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 49
    • 84655164923 scopus 로고    scopus 로고
    • Experimental mouse tumour models: What can be learnt about human cancer immunology?
    • Dranoff, G. Experimental mouse tumour models: what can be learnt about human cancer immunology? Nat. Rev. Immunol. 12, 61-66 (2011).
    • (2011) Nat. Rev. Immunol , vol.12 , pp. 61-66
    • Dranoff, G.1
  • 50
    • 84876741058 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function
    • McNamee, E. N., Korns Johnson, D., Homann, D. & Clambey, E. T. Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunol. Res. 55, 58-70 (2013).
    • (2013) Immunol. Res , vol.55 , pp. 58-70
    • McNamee, E.N.1    Korns Johnson, D.2    Homann, D.3    Clambey, E.T.4
  • 51
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Tregcells
    • Facciabene, A. et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Tregcells. Nature 475, 226-230 (2011).
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1
  • 52
    • 77957350018 scopus 로고    scopus 로고
    • Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression
    • Doedens, A. L. et al. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 70, 7465-7475 (2010).
    • (2010) Cancer Res , vol.70 , pp. 7465-7475
    • Doedens, A.L.1
  • 53
    • 84923106307 scopus 로고    scopus 로고
    • Combining radiation and immunotherapy: A new systemic therapy for solid tumors?
    • Tang, C. et al. Combining radiation and immunotherapy: a new systemic therapy for solid tumors? Cancer Immunol. Res. 2, 831-838 (2014).
    • (2014) Cancer Immunol Res , vol.2 , pp. 831-838
    • Tang, C.1
  • 54
    • 84953309212 scopus 로고    scopus 로고
    • Immune-related adverse events with immune checkpoint blockade: A comprehensive review
    • Michot, J. M. et al. Immune-related adverse events with immune checkpoint blockade: A comprehensive review. Eur. J. Cancer 54, 139-148 (2016).
    • (2016) Eur. J. Cancer , vol.54 , pp. 139-148
    • Michot, J.M.1
  • 55
    • 84949988089 scopus 로고    scopus 로고
    • Toxicities of the anti-PD.1 and anti-PD.L1 immune checkpoint antibodies
    • Naidoo, J. et al. Toxicities of the anti-PD.1 and anti-PD.L1 immune checkpoint antibodies. Ann. Oncol. 26, 2375-2391 (2015).
    • (2015) Ann. Oncol , vol.26 , pp. 2375-2391
    • Naidoo, J.1
  • 56
    • 0037406666 scopus 로고    scopus 로고
    • Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma
    • Picozzi, V. J., Kozarek, R. A. & Traverso, L. W. Interferon-based adjuvant chemoradiation therapy after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am. J. Surg. 185, 476-480 (2003).
    • (2003) Am. J. Surg , vol.185 , pp. 476-480
    • Picozzi, V.J.1    Kozarek, R.A.2    Traverso, L.W.3
  • 57
    • 79251579661 scopus 로고    scopus 로고
    • Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b-based chemoradiation: ACOSOG Trial Z05031
    • Picozzi, V. J. et al. Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b-based chemoradiation: ACOSOG Trial Z05031. Ann. Oncol. 22, 348-354 (2011).
    • (2011) Ann. Oncol , vol.22 , pp. 348-354
    • Picozzi, V.J.1
  • 58
    • 85018269954 scopus 로고    scopus 로고
    • Multicenter evaluation of the tolerability of combined treatment with PD.1 and CTLA.4 immune checkpoint inhibitors and palliative radiation therapy
    • Bang, A. et al. Multicenter evaluation of the tolerability of combined treatment with PD.1 and CTLA.4 immune checkpoint inhibitors and palliative radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 98, 344-351 (2017).
    • (2017) Int. J. Radiat. Oncol. Biol. Phys. , vol.98 , pp. 344-351
    • Bang, A.1
  • 61
    • 84944455756 scopus 로고    scopus 로고
    • Dose-escalated, intratumoral TLR9 agonist and low-dose radiation induce abscopal effects in follicular lymphoma
    • Kohrt, H. E. et al. Dose-escalated, intratumoral TLR9 agonist and low-dose radiation induce abscopal effects in follicular lymphoma. Blood 124, 3092 (2014).
    • (2014) Blood , vol.124 , pp. 3092
    • Kohrt, H.E.1
  • 62
    • 78049420571 scopus 로고    scopus 로고
    • In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study
    • Brody, J. D. et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: a phase I/II study. J. Clin. Oncol. 28, 4324-4332 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 4324-4332
    • Brody, J.D.1
  • 63
    • 80051988912 scopus 로고    scopus 로고
    • The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells
    • Hams, E. et al. The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock 36, 295-302 (2011).
    • (2011) Shock , vol.36 , pp. 295-302
    • Hams, E.1
  • 64
    • 84948127396 scopus 로고    scopus 로고
    • Kill-painting of hypoxic tumours in charged particle therapy
    • Tinganelli, W. et al. Kill-painting of hypoxic tumours in charged particle therapy. Sci. Rep. 5, 17016 (2015).
    • (2015) Sci. Rep , vol.5 , pp. 17016
    • Tinganelli, W.1
  • 66
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden, E. B., Demaria, S., Schiff, P. B., Chachoua, A. & Formenti, S. C. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol. Res. 1, 365-372 (2013).
    • (2013) Cancer Immunol. Res , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 69
    • 84941993185 scopus 로고    scopus 로고
    • Subversion of anticancer immunosurveillance by radiotherapy
    • Zitvogel, L. & Kroemer, G. Subversion of anticancer immunosurveillance by radiotherapy. Nat. Immunol. 16, 1005-1007 (2015).
    • (2015) Nat. Immunol , vol.16 , pp. 1005-1007
    • Zitvogel, L.1    Kroemer, G.2
  • 70
    • 79952283465 scopus 로고    scopus 로고
    • How to improve the immunogenicity of chemotherapy and radiotherapy
    • Ma, Y. et al. How to improve the immunogenicity of chemotherapy and radiotherapy. Cancer Metastasis Rev. 30, 71-82 (2011).
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 71-82
    • Ma, Y.1
  • 71
    • 84903987614 scopus 로고    scopus 로고
    • Antitumor immunity induced after irradiation
    • Gorin, J..B. et al. Antitumor immunity induced after irradiation. Neoplasia 16, 319-328 (2014).
    • (2014) Neoplasia , vol.16 , pp. 319-328
    • Gorin, J.B.1
  • 72
    • 84978665423 scopus 로고    scopus 로고
    • Combination of radiotherapy checkpoint blockade resistance and vaccination overcomes checkpoint blockade resistance
    • Zheng, W. et al. Combination of radiotherapy checkpoint blockade resistance and vaccination overcomes checkpoint blockade resistance. Oncotarget 7, 43039-43051 (2016).
    • (2016) Oncotarget , vol.7 , pp. 43039-43051
    • Zheng, W.1
  • 73
    • 84856519280 scopus 로고    scopus 로고
    • A live-attenuated listeria vaccine (ANZ.100) and a live-attenuated listeria vaccine expressing mesothelin (CRS.207) for advanced cancers: Phase i studies of safety and immune induction
    • Le, D. T. et al. A live-attenuated listeria vaccine (ANZ.100) and a live-attenuated listeria vaccine expressing mesothelin (CRS.207) for advanced cancers: phase I studies of safety and immune induction. Clin. Cancer Res. 18, 858-868 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 858-868
    • Le, D.T.1
  • 74
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocytemacrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff, G. et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocytemacrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl Acad. Sci. USA 90, 3539-3543 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1
  • 75
    • 84919486724 scopus 로고    scopus 로고
    • Combination regimens of radiation therapy and therapeutic cancer vaccines: Mechanisms and opportunities
    • Garnett-Benson, C., Hodge, J. W. & Gameiro, S. R. Combination regimens of radiation therapy and therapeutic cancer vaccines: mechanisms and opportunities. Semin. Radiat. Oncol. 25, 46-53 (2015).
    • (2015) Semin. Radiat. Oncol , vol.25 , pp. 46-53
    • Garnett-Benson, C.1    Hodge, J.W.2    Gameiro, S.R.3
  • 76
    • 85009944195 scopus 로고    scopus 로고
    • Smart radiation therapy biomaterials
    • Ngwa, W. et al. Smart radiation therapy biomaterials. Int. J. Radiat. Oncol. 97, 624-637 (2017).
    • (2017) Int. J. Radiat. Oncol , vol.97 , pp. 624-637
    • Ngwa, W.1
  • 77
    • 84986280792 scopus 로고    scopus 로고
    • Engineering nanoparticles to overcome barriers to immunotherapy
    • Toy, R. & Roy, K. Engineering nanoparticles to overcome barriers to immunotherapy. Bioeng. Transl Med. 1, 47-62 (2016).
    • (2016) Bioeng. Transl Med , vol.1 , pp. 47-62
    • Toy, R.1    Roy, K.2
  • 78
    • 84886749794 scopus 로고    scopus 로고
    • Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response
    • Thomas, S. N., Vokali, E., Lund, A. W., Hubbell, J. A. & Swartz, M. A. Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response. Biomaterials 35, 814-824 (2014).
    • (2014) Biomaterials , vol.35 , pp. 814-824
    • Thomas, S.N.1    Vokali, E.2    Lund, A.W.3    Hubbell, J.A.4    Swartz, M.A.5
  • 79
    • 84957035779 scopus 로고    scopus 로고
    • Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation
    • Li, S. Y. et al. Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation. J. Control. Release 231, 17-28 (2016).
    • (2016) J. Control. Release , vol.231 , pp. 17-28
    • Li, S.Y.1
  • 80
    • 84990996804 scopus 로고    scopus 로고
    • Gold nanoparticles enhance antitumor effect of radiotherapy to hypoxic tumor
    • Kim, M. S. et al. Gold nanoparticles enhance antitumor effect of radiotherapy to hypoxic tumor. Radiat. Oncol. J. 34, 230-238 (2016).
    • (2016) Radiat. Oncol. J , vol.34 , pp. 230-238
    • Kim, M.S.1
  • 81
    • 84922422524 scopus 로고    scopus 로고
    • Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters
    • Sinha, N. et al. Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters. Int. J. Radiat. Oncol. Biol. Phys. 91, 385-392 (2015).
    • (2015) Int. J. Radiat. Oncol. Biol. Phys , vol.91 , pp. 385-392
    • Sinha, N.1
  • 82
    • 84940767069 scopus 로고    scopus 로고
    • AGuIX nanoparticles as a promising platform for image-guided radiation therapy
    • Detappe, A. et al. AGuIX nanoparticles as a promising platform for image-guided radiation therapy. Cancer Nanotechnol. 6, 4 (2015).
    • (2015) Cancer Nanotechnol , vol.6 , pp. 4
    • Detappe, A.1
  • 83
    • 84908597548 scopus 로고    scopus 로고
    • Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells
    • Luchette, M., Korideck, H., Makrigiorgos, M., Tillement, O. & Berbeco, R. Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells. Nanomedicine 10, 1751-1755 (2014).
    • (2014) Nanomedicine , vol.10 , pp. 1751-1755
    • Luchette, M.1    Korideck, H.2    Makrigiorgos, M.3    Tillement, O.4    Berbeco, R.5
  • 84
    • 85045876206 scopus 로고    scopus 로고
    • eds Wong, J. Y. C.,Schultheiss, T. E. & Radany, E. H. Springer
    • Low, D. A. in Advances in Radiation Oncology (eds Wong, J. Y. C.,Schultheiss, T. E. & Radany, E. H.) 41-67 (Springer, 2017).
    • (2017) Advances in Radiation Oncology , pp. 41-67
    • Low, D.A.1
  • 85
    • 84931846432 scopus 로고    scopus 로고
    • Gadolinium-based nanoparticles for theranostic MRI-radiosensitization
    • Lux, F. et al. Gadolinium-based nanoparticles for theranostic MRI-radiosensitization. Nanomedicine 10, 1801-1815 (2015).
    • (2015) Nanomedicine , vol.10 , pp. 1801-1815
    • Lux, F.1
  • 86
    • 84934896807 scopus 로고    scopus 로고
    • Nanomedicine for cancer immunotherapy: Tracking cancer-specific T. Cells in vivo with gold nanoparticles and CT imaging
    • Meir, R. et al. Nanomedicine for cancer immunotherapy: tracking cancer-specific T.cells in vivo with gold nanoparticles and CT imaging. ACS Nano 9, 6363-6372 (2015).
    • (2015) ACS Nano , vol.9 , pp. 6363-6372
    • Meir, R.1
  • 87
    • 84879645728 scopus 로고    scopus 로고
    • Radiation and immunotherapy: A synergistic combination
    • Kalbasi, A., June, C. H., Haas, N. & Vapiwala, N. Radiation and immunotherapy: a synergistic combination. J. Clin. Invest. 123, 2756-2763 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 2756-2763
    • Kalbasi, A.1    June, C.H.2    Haas, N.3    Vapiwala, N.4
  • 88
    • 84890068807 scopus 로고    scopus 로고
    • Vaccine delivery with microneedle skin patches in nonhuman primates
    • DeMuth, P. C. et al. Vaccine delivery with microneedle skin patches in nonhuman primates. Nat. Biotechnol. 31, 1082-1085 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 1082-1085
    • DeMuth, P.C.1
  • 89
    • 84865459821 scopus 로고    scopus 로고
    • Differential functional effects of biomaterials on dendritic cell maturation
    • Park, J. & Babensee, J. E. Differential functional effects of biomaterials on dendritic cell maturation. Acta Biomater. 8, 3606-3617 (2012).
    • (2012) Acta Biomater , vol.8 , pp. 3606-3617
    • Park, J.1    Babensee, J.E.2
  • 90
    • 84912561549 scopus 로고    scopus 로고
    • Phenotype and polarization of autologous T cells by biomaterialtreated dendritic cells
    • Park, J., Gerber, M. H. & Babensee, J. E. Phenotype and polarization of autologous T cells by biomaterialtreated dendritic cells. J. Biomed. Mater. Res. A 103, 170-184 (2015).
    • (2015) J. Biomed. Mater. Res. A , vol.103 , pp. 170-184
    • Park, J.1    Gerber, M.H.2    Babensee, J.E.3
  • 91
    • 77953081609 scopus 로고    scopus 로고
    • The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells
    • Shokouhi, B. et al. The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells. Biomaterials 31, 5759-5771 (2010).
    • (2010) Biomaterials , vol.31 , pp. 5759-5771
    • Shokouhi, B.1
  • 92
    • 78649760576 scopus 로고    scopus 로고
    • The role of integrins in the recognition and response of dendritic cells to biomaterials
    • Rogers, T. H. & Babensee, J. E. The role of integrins in the recognition and response of dendritic cells to biomaterials. Biomaterials 32, 1270-1279 (2011).
    • (2011) Biomaterials , vol.32 , pp. 1270-1279
    • Rogers, T.H.1    Babensee, J.E.2
  • 93
    • 29444441343 scopus 로고    scopus 로고
    • Manifold mechanisms of Toll-like receptor-ligand recognition
    • Ishii, K. J., Coban, C. & Akira, S. Manifold mechanisms of Toll-like receptor-ligand recognition. J. Clin. Immunol. 25, 511-521 (2005).
    • (2005) J. Clin. Immunol , vol.25 , pp. 511-521
    • Ishii, K.J.1    Coban, C.2    Akira, S.3
  • 94
    • 10644221275 scopus 로고    scopus 로고
    • The effect of the physical form of poly(lactic-co-glycolic acid) carriers on the humoral immune response to co-delivered antigen
    • Bennewitz, N. L. & Babensee, J. E. The effect of the physical form of poly(lactic-co-glycolic acid) carriers on the humoral immune response to co-delivered antigen. Biomaterials 26, 2991-2999 (2005).
    • (2005) Biomaterials , vol.26 , pp. 2991-2999
    • Bennewitz, N.L.1    Babensee, J.E.2
  • 95
    • 0142258106 scopus 로고    scopus 로고
    • Humoral immune responses to model antigen co-delivered with biomaterials used in tissue engineering
    • Matzelle, M. M. & Babensee, J. E. Humoral immune responses to model antigen co-delivered with biomaterials used in tissue engineering. Biomaterials 25, 295-304 (2004).
    • (2004) Biomaterials , vol.25 , pp. 295-304
    • Matzelle, M.M.1    Babensee, J.E.2
  • 96
    • 40649091858 scopus 로고    scopus 로고
    • Interaction of dendritic cells with biomaterials
    • Babensee, J. E. Interaction of dendritic cells with biomaterials. Semin. Immunol. 20, 101-108 (2008).
    • (2008) Semin. Immunol , vol.20 , pp. 101-108
    • Babensee, J.E.1
  • 97
    • 84991203520 scopus 로고    scopus 로고
    • Acute toxicity with intensity modulated radiotherapy versus 3-dimensional conformal radiotherapy during preoperative chemoradiation for locally advanced rectal cancer
    • Ng, S. Y. et al. Acute toxicity with intensity modulated radiotherapy versus 3-dimensional conformal radiotherapy during preoperative chemoradiation for locally advanced rectal cancer. Radiother. Oncol. 121, 252-257 (2016).
    • (2016) Radiother. Oncol. , vol.121 , pp. 252-257
    • Ng, S.Y.1
  • 98
    • 84878567974 scopus 로고    scopus 로고
    • Depleting tumor-specific Tregs at a single site eradicates disseminated tumors
    • Marabelle, A. et al. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J. Clin. Invest. 123, 2447-2463 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 2447-2463
    • Marabelle, A.1
  • 99
    • 84895886897 scopus 로고    scopus 로고
    • Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer
    • Fransen, M. F. et al. Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer. Vaccine 32, 1654-1660 (2014).
    • (2014) Vaccine , vol.32 , pp. 1654-1660
    • Fransen, M.F.1
  • 100
    • 79954579274 scopus 로고    scopus 로고
    • Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody
    • Fransen, M. F., Sluijter, M., Morreau, H., Arens, R. & Melief, C. J. M. Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody. Clin. Cancer Res. 17, 2270-2280 (2011).
    • (2011) Clin. Cancer Res , vol.17 , pp. 2270-2280
    • Fransen, M.F.1    Sluijter, M.2    Morreau, H.3    Arens, R.4    Melief, C.J.M.5
  • 101
    • 20344375444 scopus 로고    scopus 로고
    • The controversial abscopal effect
    • Kaminski, J. M. et al. The controversial abscopal effect. Cancer Treatment Rev. 31, 159-172 (2005).
    • (2005) Cancer Treatment Rev , vol.31 , pp. 159-172
    • Kaminski, J.M.1
  • 102
    • 84896724517 scopus 로고    scopus 로고
    • Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing
    • Gameiro, S. R. et al. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing. Oncotarget 5, 403-416 (2014).
    • (2014) Oncotarget , vol.5 , pp. 403-416
    • Gameiro, S.R.1
  • 103
    • 0025057301 scopus 로고
    • Skin involvement as the presenting sign of internal carcinoma: A retrospective study of 7316 cancer patients
    • Lookingbill, D. P., Spangler, N. & Sexton, F. M. Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7316 cancer patients. J. Am. Acad. Dermatol. 22, 19-26 (1990).
    • (1990) J. Am. Acad. Dermatol , vol.22 , pp. 19-26
    • Lookingbill, D.P.1    Spangler, N.2    Sexton, F.M.3
  • 104
    • 0037330518 scopus 로고    scopus 로고
    • Cutaneous metastasis: A meta-analysis of data
    • Krathen, R. A., Orengo, I. F. & Rosen, T. Cutaneous metastasis: a meta-analysis of data. South. Med. J. 96, 164-167 (2003).
    • (2003) South. Med. J , vol.96 , pp. 164-167
    • Krathen, R.A.1    Orengo, I.F.2    Rosen, T.3
  • 105
    • 33745684527 scopus 로고    scopus 로고
    • Metastasis: A question of life or death
    • Mehlen, P. & Puisieux, A. Metastasis: a question of life or death. Nat. Rev. Cancer 6, 449-458 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 449-458
    • Mehlen, P.1    Puisieux, A.2
  • 106
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559-1564 (2011).
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 108
    • 84994713359 scopus 로고    scopus 로고
    • Cancer nanomedicine: Progress, challenges and opportunities
    • Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Cancer nanomedicine: progress, challenges and opportunities. Nat. Rev. Cancer 17, 20-37 (2016).
    • (2016) Nat. Rev. Cancer , vol.17 , pp. 20-37
    • Shi, J.1    Kantoff, P.W.2    Wooster, R.3    Farokhzad, O.C.4
  • 109
    • 73649109907 scopus 로고    scopus 로고
    • Biological in situ dose painting for image-guided radiation therapy using drug-loaded implantable devices
    • Cormack, R. A., Sridhar, S., Suh, W. W., D'Amico, A. V. & Makrigiorgos, G. M. Biological in situ dose painting for image-guided radiation therapy using drug-loaded implantable devices. Int. J. Radiat. Oncol. 76, 615-623 (2010).
    • (2010) Int. J. Radiat. Oncol , vol.76 , pp. 615-623
    • Cormack, R.A.1    Sridhar, S.2    Suh, W.W.3    D'Amico, A.V.4    Makrigiorgos, G.M.5
  • 110
    • 84922445828 scopus 로고    scopus 로고
    • Nanoparticle-based brachytherapy spacers for delivery of localized combined chemoradiation therapy
    • Kumar, R. et al. Nanoparticle-based brachytherapy spacers for delivery of localized combined chemoradiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 91, 393-400 (2015).
    • (2015) Int. J. Radiat. Oncol. Biol. Phys , vol.91 , pp. 393-400
    • Kumar, R.1
  • 111
    • 75749093027 scopus 로고    scopus 로고
    • Emerging applications of stimuliresponsive polymer materials
    • Stuart, M. A. et al. Emerging applications of stimuliresponsive polymer materials. Nat. Mater. 9, 101-113 (2010).
    • (2010) Nat. Mater , vol.9 , pp. 101-113
    • Stuart, M.A.1
  • 112
    • 77955470132 scopus 로고    scopus 로고
    • Chitosan film containing poly(D,L-lactic-co-glycolic acid) nanoparticles: A platform for localized dual-drug release
    • Tada, D. B. et al. Chitosan film containing poly(D,L-lactic-co-glycolic acid) nanoparticles: a platform for localized dual-drug release. Pharm. Res. 27, 1738-1745 (2010).
    • (2010) Pharm. Res , vol.27 , pp. 1738-1745
    • Tada, D.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.