Kill-painting of hypoxic tumours in charged particle therapy

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Tinganelli, Walter ^a,b   Durante, Marco ^a,c   Hirayama, Ryoichi ^b   Krämer, Michael ^a   Maier, Andreas ^a   Kraft Weyrather, Wilma ^a   Furusawa, Yoshiya ^b   Friedrich, Thomas ^a   Scifoni, Emanuele ^a  

^a Biophysics Department   (Germany)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ANIMAL; CELL HYPOXIA; CELL SURVIVAL; CHO CELL LINE; CRICETULUS; HAMSTER; HUMAN; IMAGE GUIDED RADIOTHERAPY; NEOPLASMS; PHYSIOLOGY; RADIATION RESPONSE; RADIATION TOLERANCE; RADIOTHERAPY PLANNING SYSTEM;

ANIMALS; CELL HYPOXIA; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; NEOPLASMS; OXYGEN; RADIATION TOLERANCE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, IMAGE-GUIDED;

EID: 84948127396     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17016     Document Type: Article

References (60)

1. Hanahan, D., Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
2. Wilson, W. R., Hay, M. P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer 11, 393-410 (2011).
3. Brown, J. M., Wilson, W. R. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer 4, 437-447 (2004).
4. Schardt, D., Elsässer, T., Schulz-Ertner, D. Heavy-ion tumor therapy: Physical and radiobiological benefits. Rev. Mod. Phys. 82, 383-425 (2010).
5. Kamada, T. et al. Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. Lancet Oncol 16, e93-e100 (2015).
6. Loeffler, J. S., Durante, M. Charged particle therapy-optimization, challenges and future directions. Nat. Rev. Clin. Oncol. 10, 411-424 (2013).
7. Blakely, E. A., Ngo, F. Q. H., Curtis, S. B., Tobias, C. A. Heavy-ion radiobiology-cellular studies. Adv. Radiat. Biol. 11, 295-389 (1984).
8. Furusawa, Y. et al. Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-(12)C-and (20) Ne-ion beams. Radiat. Res. 154, 485-496 (2000).
9. Alper, T., Bryant, P. E. Reduction in oxygen enhancement ratio with increase in LET: tests of two hypotheses. Int. J. Radiat. Biol. 26, 203-218 (1974).
10. Baverstock, K. F., Burns, W. G. Primary production of oxygen from irradiated water as an explanation for decreased radiobiological oxygen enhancement at high LET. Nature 260, 316-318 (1976).
11. Michael, B. D., Prise, K. M. A multiple-radical model for radiation action on DNA and the dependence of OER on LET. Int. J. Radiat. Biol. 69, 351-358 (1996).
12. Mothersill, C., Seymour, C. Changing paradigms in radiobiology. Mutat. Res. 750, 85-95 (2012).
13. Tsujii, H. et al. Carbon ion radiotherapy (Springer-Verlag, Berlin, 2014).
14. Pignalosa, D., Durante, M. Overcoming resistance of cancer stem cells. Lancet Oncol. 13, e187-188 (2012).
15. Nakano, T. et al. Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia. Clin. Cancer Res. 12, 2185-2190 (2006).
16. McKeown, S. R. Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. Br. J. Radiol. 87, 20130676 (2014).
17. Wouters, B. G., Brown, J. M. Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat. Res. 147, 541-550 (1997).
18. Amaldi, U., Kraft, G. Radiotherapy with beams of carbon ions. Rep. Prog. Phys. 68, 1861 (2005).
19. Horcicka, M., Meyer, C., Buschbacher, A., Durante, M., Krämer, M. Algorithms for the optimization of RBE-weighted dose in particle therapy. Phys. Med. Biol. 58 (2012).
20. Alper, T., Howard-Flanders, P. Role of oxygen in modifying the radiosensitivity of E. coli B. Nature 178, 978-979 (1956).
21. Boppart, S. A., Richards-Kortum, R. Point-of-care and point-of-procedure optical imaging technologies for primary care and global health. Sci. Transl. Med. 6, 253rv2 (2014).
22. Horsman, M. R., Mortensen, L. S., Petersen, J. B., Busk, M., Overgaard, J. Imaging hypoxia to improve radiotherapy outcome. Nat. Rev. Clin. Oncol. 9, 674-687 (2012).
23. Dubois, L. J. et al. Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging. PNAS 108, 14620-14625 (2011).
24. Lupo, J. M., Nelson, S. J. Advanced magnetic resonance imaging methods for planning and monitoring radiation therapy in patients with high-grade glioma. Semin. Radiat. Oncol. 24, 248-258 (2014).
25. Biswal, N. C. et al. Imaging tumor hypoxia by near-infrared fluorescence tomography. J. Biomed. Opt. 16, 066009 (2011).
26. Kiyose, K. et al. Hypoxia-sensitive fluorescent probes for in vivo real-time fluorescence imaging of acute ischemia. J. Am. Chem. Soc. 132, 15846-15848 (2010).
27. Holt, R. W. et al. Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies. Phys. Med. Biol. 59, 5317-5328 (2014).
28. Overgaard, J. Hypoxic radiosensitization: adored and ignored. J. Clin. Oncol. 25, 4066-4074 (2007).
29. Liauw, S. L., Connell, P. P., Weichselbaum, R. R. New paradigms and future challenges in radiation oncology: an update of biological targets and technology. Sci. Transl. Med. 5, 173sr2 (2013).
30. Bentzen, S. M. Theragnostic imaging for radiation oncology: dose-painting by numbers. Lancet Oncol. 6, 112-117 (2005).
31. Giantsoudi, D. et al. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. Int. J. Radiat. Oncol. Biol. Phys. 87, 216-222 (2013).
32. Bassler, N. et al. LET-painting increases tumour control probability in hypoxic tumours. Acta Oncol. 53, 25-32 (2014).
33. Scifoni, E. et al. Including oxygen enhancement ratio in ion beam treatment planning: model implementation and experimental verification. Phys. Med. Biol. 58, 3871-3895 (2013).
34. Wenzl, T., Wilkens, J. J. Modelling of the oxygen enhancement ratio for ion beam radiation therapy. Phys. Med. Biol. 56, 3251-3268 (2011).
35. Antonovic, L. et al. Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes. J. Radiat. Res. 55, 902-911, (2014).
36. Stewart, R. D. et al. Effects of radiation quality and oxygen on clustered DNA lesions and cell death. Radiat. Res. 176, 587-602 (2011).
37. Tinganelli, W. et al. Influence of acute hypoxia and radiation quality on cell survival. J. Radiat. Res. 54, 123-130 (2013).
38. Meesungnoen, J., Jay-Gerin, J.-P. High-LET ion radiolysis of water: oxygen production in tracks. Radiat. Res. 171, 379-386 (2009).
39. Weyrather, W. K., Ritter, S., Scholz, M., Kraft, G. RBE for carbon track-segment irradiation in cell lines of differing repair capacity. Int. J. Radiat. Biol. 75, 1357-1364 (1999).
40. Hirayama, R. et al. OH radicals from the indirect actions of X-rays induce cell lethality and mediate the majority of the oxygen enhancement effect. Radiat. Res. 180, 514-523 (2013).
41. Carlson, D. J., Stewart, R. D., Semenenko, V. A. Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters. Med. Phys. 33, 3105-3115 (2006).
42. Krämer, M. et al. Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization. Phys. Med. Biol. 45, 3299-3317 (2000).
43. Krämer, M., Scholz, M. Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose. Phys. Med. Biol. 45, 3319-3330 (2000).
44. Krämer, M., Scifoni, E., Schmitz, F., Sokol, O., Durante, M. Overview of recent advances in treatment planning for ion beam radiotherapy. Eur. Phys. J. D 68, 306 (2014).
45. Fowler, J. F. 21 years of biologically effective dose. Br. J. Radiol. 83, 554-568 (2010).
46. Toma-Dasu, I. et al. Dose prescription and treatment planning based on FMISO-PET hypoxia. Acta Oncol. 51, 222-230 (2012).
47. Toma-Dasu, I., Dasu, A., Brahme, A. Quantifying tumour hypoxia by PET imaging-a theoretical analysis. Adv. Exp. Med. Biol. 645, 267-272 (2009).
48. Bowen, S. R., van der Kogel, A. J., Nordsmark, M., Bentzen, S. M., Jeraj, R. Characterization of positron emission tomography hypoxia tracer uptake and tissue oxygenation via electrochemical modeling. Nucl. Med. Biol. 38, 771-780 (2011).
49. Ma, N. et al. Influence of chronic hypoxia and radiation quality on cell survival. J. Radiat. Res. 54, i13-22 (2013).
50. Junttila, M. R., de Sauvage, F. J. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501, 346-354 (2013).
51. Vlashi, E. et al. In vivo imaging, tracking, and targeting of cancer stem cells. J. Natl. Cancer Inst. 101, 350-359 (2009).
52. Gaedicke, S. et al. Noninvasive positron emission tomography and fluorescence imaging of CD133+ tumor stem cells. Proc. Natl. Acad. Sci. USA 111, E692-701 (2014).
53. Olive, P. L. Retention of gammaH2AX foci as an indication of lethal DNA damage. Radiother. Oncol. 101, 18-23 (2011).
54. Bristow, R. G., Hill, R. P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer 8, 180-192 (2008).
55. Schicker, C., Von Neubeck, C., Kopf, U., Kraft-Weyrather, W. Zellkultur Bestrahlungskammer. Patent Ep 09 002 402, 7 (2009).
56. Hirayama, R., Furusawa, Y., Fukawa, T., Ando, K. Repair kinetics of DNA-DSB induced by X-rays or carbon ions under oxic and hypoxic conditions. J. Radiat. Res. 46, 325-332 (2005).
57. Hirayama, R. et al. Radioprotection by DMSO in nitrogen-saturated mammalian cells exposed to helium ion beams. Rad. Chem. Phys. 78, 1175-1178 (2009).
58. ICRU. International Commission on Radiation Units and Measurements Report 16: Linear Energy Transfer. (Washington D.C., 1970).
59. Krämer, M., Scholz, M. Rapid calculation of biological effects in ion radiotherapy. Phys. Med. Biol. 51, 1959-1970 (2006).
60. Krämer, M., Scifoni, E., Wälzlein, C., Durante, M. Ion beams in radiotherapy-from tracks to treatment planning. J. Phys. Conf. Ser. 373, 012017 (2012).