-
1
-
-
65649113763
-
Histone H2AX is integral to hypoxia-driven neovascularization
-
Economopoulou, M. et al. Histone H2AX is integral to hypoxia-driven neovascularization. Nat. Med. 15, 553-558 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 553-558
-
-
Economopoulou, M.1
-
2
-
-
84864701748
-
Pathological neoangiogenesis depends on oxidative stress regulation by ATM
-
Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat. Med. 18, 1208-1216 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1208-1216
-
-
Okuno, Y.1
Nakamura-Ishizu, A.2
Otsu, K.3
Suda, T.4
Kubota, Y.5
-
3
-
-
0038626211
-
Tumour response to radiotherapy regulated by endothelial cell apoptosis
-
Garcia-Barros, M. et al. Tumour response to radiotherapy regulated by endothelial cell apoptosis. Science 300, 1155-1159 (2003).
-
(2003)
Science
, vol.300
, pp. 1155-1159
-
-
Garcia-Barros, M.1
-
4
-
-
0035854479
-
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
-
Paris, F. et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293, 293-297 (2001).
-
(2001)
Science
, vol.293
, pp. 293-297
-
-
Paris, F.1
-
5
-
-
84873038441
-
MiRNAs as modulators of angiogenesis
-
Landskroner-Eiger, S., Moneke, I. & Sessa, W. C. miRNAs as modulators of angiogenesis. Cold Spring Harb. Perspect. Med. 3, a006643 (2013).
-
(2013)
Cold Spring Harb. Perspect. Med.
, vol.3
, pp. a006643
-
-
Landskroner-Eiger, S.1
Moneke, I.2
Sessa, W.C.3
-
6
-
-
52049092728
-
An optimized three-dimensional in vitro model for the analysis of angiogenesis
-
Nakatsu, M. N. & Hughes, C. C. An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods Enzymol. 443, 65-82 (2008).
-
(2008)
Methods Enzymol.
, vol.443
, pp. 65-82
-
-
Nakatsu, M.N.1
Hughes, C.C.2
-
7
-
-
55449137271
-
Chapter 6. Ocular models of angiogenesis
-
Aguilar, E. et al. Chapter 6. Ocular models of angiogenesis. Methods Enzymol. 444, 115-158 (2008).
-
(2008)
Methods Enzymol.
, vol.444
, pp. 115-158
-
-
Aguilar, E.1
-
8
-
-
70450175957
-
Targeting angiogenesis: Progress with anti-VEGF treatment with large molecules
-
Grothey, A. & Galanis, E. Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat. Rev. Clin. Oncol. 6, 507-518 (2009).
-
(2009)
Nat. Rev. Clin. Oncol.
, vol.6
, pp. 507-518
-
-
Grothey, A.1
Galanis, E.2
-
9
-
-
84908155926
-
Sequencing of antiangiogenic agents in the treatment of metastatic colorectal cancer
-
Lee, J. J. & Chu, E. Sequencing of antiangiogenic agents in the treatment of metastatic colorectal cancer. Clin. Colorectal Cancer 13, 135-144 (2014).
-
(2014)
Clin. Colorectal Cancer
, vol.13
, pp. 135-144
-
-
Lee, J.J.1
Chu, E.2
-
10
-
-
84911905421
-
The glioblastoma vasculature as a target for cancer therapy
-
Dimberg, A. The glioblastoma vasculature as a target for cancer therapy. Biochem. Soc. Trans. 42, 1647-1652 (2014).
-
(2014)
Biochem. Soc. Trans.
, vol.42
, pp. 1647-1652
-
-
Dimberg, A.1
-
11
-
-
84906706945
-
Small RNA combination therapy for lung cancer
-
Xue, W. et al. Small RNA combination therapy for lung cancer. Proc. Natl Acad. Sci. USA 111, E3553-E3561 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. E3553-E3561
-
-
Xue, W.1
-
12
-
-
84905718745
-
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
-
Dahlman, J. E. et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat. Nanotechnol. 9, 648-655 (2014).
-
(2014)
Nat. Nanotechnol.
, vol.9
, pp. 648-655
-
-
Dahlman, J.E.1
-
13
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumours to increased local invasion and distant metastasis
-
Pàez-Ribes, M. et al. Antiangiogenic therapy elicits malignant progression of tumours to increased local invasion and distant metastasis. Cancer Cell 15, 220-231 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Pàez-Ribes, M.1
-
14
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumour angiogenesis
-
Ebos, J. M. L. et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumour angiogenesis. Cancer Cell 15, 232-239 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.L.1
-
15
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
-
(2009)
Cell
, vol.136
, pp. 215-233
-
-
Bartel, D.P.1
-
16
-
-
33746581694
-
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause aicardi-goutieres syndrome at the AGS1 locus
-
Crow, Y. J. et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat. Genet. 38, 917-920 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 917-920
-
-
Crow, Y.J.1
-
17
-
-
34548327158
-
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus
-
Lee-Kirsch, M. A. et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat. Genet. 39, 1065-1067 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 1065-1067
-
-
Lee-Kirsch, M.A.1
-
18
-
-
34548334617
-
C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
-
Richards, A. et al. C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy. Nat. Genet. 39, 1068-1070 (2007).
-
(2007)
Nat. Genet.
, vol.39
, pp. 1068-1070
-
-
Richards, A.1
-
19
-
-
47249142894
-
New roles for the major human 3′-5′ exonuclease TREX1 in human disease
-
Kavanagh, D. et al. New roles for the major human 3′-5′ exonuclease TREX1 in human disease. Cell Cycle 7, 1718-1725 (2008).
-
(2008)
Cell Cycle
, vol.7
, pp. 1718-1725
-
-
Kavanagh, D.1
-
20
-
-
84870936544
-
Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach
-
Cambronne, X. A., Shen, R., Auer, P. L. & Goodman, R. H. Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach. Proc. Natl Acad. Sci. USA 109, 20473-20478 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 20473-20478
-
-
Cambronne, X.A.1
Shen, R.2
Auer, P.L.3
Goodman, R.H.4
-
21
-
-
77958114725
-
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
-
Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A. & Lieberman, J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat. Immunol. 11, 1005-1013 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1005-1013
-
-
Yan, N.1
Regalado-Magdos, A.D.2
Stiggelbout, B.3
Lee-Kirsch, M.A.4
Lieberman, J.5
-
22
-
-
36248988008
-
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
-
Yang, Y. G., Lindahl, T. & Barnes, D. E. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131, 873-886 (2007).
-
(2007)
Cell
, vol.131
, pp. 873-886
-
-
Yang, Y.G.1
Lindahl, T.2
Barnes, D.E.3
-
23
-
-
84941628442
-
Cytosolic nuclease TREX1 regulates oligosaccharyl transferase activity independent of nuclease activity to suppress immune activation
-
Hasan, M. et al. Cytosolic nuclease TREX1 regulates oligosaccharyl transferase activity independent of nuclease activity to suppress immune activation. Immunity 43, 463-474 (2015).
-
(2015)
Immunity
, vol.43
, pp. 463-474
-
-
Hasan, M.1
-
24
-
-
0029031790
-
Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
-
Angiolillo, A. L. et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J. Exp. Med. 182, 155-162 (1995).
-
(1995)
J. Exp. Med.
, vol.182
, pp. 155-162
-
-
Angiolillo, A.L.1
-
25
-
-
33645319035
-
IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain
-
Bodnar, R. J., Yates, C. C. & Wells, A. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ. Res. 98, 617-625 (2006).
-
(2006)
Circ. Res.
, vol.98
, pp. 617-625
-
-
Bodnar, R.J.1
Yates, C.C.2
Wells, A.3
-
26
-
-
68949181600
-
IP-10 induces dissociation of newly formed blood vessels
-
Bodnar, R. J., Yates, C. C., Rodgers, M. E., Du, X. & Wells, A. IP-10 induces dissociation of newly formed blood vessels. J. Cell Sci. 122, 2064-2077 (2009).
-
(2009)
J. Cell Sci.
, vol.122
, pp. 2064-2077
-
-
Bodnar, R.J.1
Yates, C.C.2
Rodgers, M.E.3
Du, X.4
Wells, A.5
-
27
-
-
36048955664
-
Immunotherapy of cancer by IL-12-based cytokine combinations
-
Weiss, J. M., Subleski, J. J., Wigginton, J. M. & Wiltrout, R. H. Immunotherapy of cancer by IL-12-based cytokine combinations. Expert Opin. Biol. Ther. 7, 1705-1721 (2007).
-
(2007)
Expert Opin. Biol. Ther.
, vol.7
, pp. 1705-1721
-
-
Weiss, J.M.1
Subleski, J.J.2
Wigginton, J.M.3
Wiltrout, R.H.4
-
28
-
-
84857692141
-
Differential macrophage programming in the tumour microenvironment
-
Ruffell, B., Affara, N. I. & Coussens, L. M. Differential macrophage programming in the tumour microenvironment. Trends Immunol. 33, 119-126 (2012).
-
(2012)
Trends Immunol.
, vol.33
, pp. 119-126
-
-
Ruffell, B.1
Affara, N.I.2
Coussens, L.M.3
-
29
-
-
77953898940
-
A microRNA targeting dicer for metastasis control
-
Martello, G. et al. A microRNA targeting dicer for metastasis control. Cell 141, 1195-1207 (2010).
-
(2010)
Cell
, vol.141
, pp. 1195-1207
-
-
Martello, G.1
-
30
-
-
79959845414
-
MicroRNAs 103 and 107 regulate insulin sensitivity
-
Trajkovski, M. et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 474, 649-653 (2011).
-
(2011)
Nature
, vol.474
, pp. 649-653
-
-
Trajkovski, M.1
-
31
-
-
84855543629
-
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
-
Garofalo, M. et al. EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat. Med. 18, 74-82 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 74-82
-
-
Garofalo, M.1
-
32
-
-
84891369796
-
Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity
-
Huang, J. W. et al. Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity. Mol. Cancer Res. 11, 1564-1573 (2013).
-
(2013)
Mol. Cancer Res.
, vol.11
, pp. 1564-1573
-
-
Huang, J.W.1
-
33
-
-
84874639351
-
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis
-
Chen, Z. et al. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J. Clin. Invest. 123, 1057-1067 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 1057-1067
-
-
Chen, Z.1
-
34
-
-
79956157422
-
A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
-
Chabot, S. et al. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. J. Exp. Med. 208, 973-986 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 973-986
-
-
Chabot, S.1
-
35
-
-
84911449436
-
The 3′-5′ DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response
-
Miyazaki, T. et al. The 3′-5′ DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response. J. Biol. Chem. 289, 32548-32558 (2014).
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 32548-32558
-
-
Miyazaki, T.1
-
36
-
-
84930007408
-
Human DNA exonuclease TREX1 is also an exoribonuclease that acts on single-stranded RNA
-
Yuan, F. et al. Human DNA exonuclease TREX1 is also an exoribonuclease that acts on single-stranded RNA. J. Biol. Chem. 290, 13344-13353 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 13344-13353
-
-
Yuan, F.1
-
37
-
-
84928243624
-
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease
-
Grieves, J. L. et al. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease. Proc. Natl Acad. Sci. USA 112, 5117-5122 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 5117-5122
-
-
Grieves, J.L.1
-
38
-
-
84900856439
-
Deregulated type I IFN response in TREX1-associated familial chilblain lupus
-
Peschke, K. et al. Deregulated type I IFN response in TREX1-associated familial chilblain lupus. J. Invest. Dermatol. 134, 1456-1459 (2014).
-
(2014)
J. Invest. Dermatol.
, vol.134
, pp. 1456-1459
-
-
Peschke, K.1
-
39
-
-
84890401989
-
The exonuclease trex1 restrains macrophage proinflammatory activation
-
Pereira-Lopes, S. et al. The exonuclease Trex1 restrains macrophage proinflammatory activation. J. Immunol. 191, 6128-6135 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 6128-6135
-
-
Pereira-Lopes, S.1
-
40
-
-
84858590826
-
Accessories to the crime: Functions of cells recruited to the tumour microenvironment
-
Hanahan, D. & Coussens, L. M. Accessories to the crime: functions of cells recruited to the tumour microenvironment. Cancer Cell 21, 309-322 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
41
-
-
84867987439
-
The impact of tumour microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies
-
Fokas, E., McKenna, W. G. & Muschel, R. J. The impact of tumour microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies. Cancer Metastasis Rev. 31, 823-842 (2012).
-
(2012)
Cancer Metastasis Rev.
, vol.31
, pp. 823-842
-
-
Fokas, E.1
McKenna, W.G.2
Muschel, R.J.3
-
42
-
-
59349089292
-
MiRNA in situ hybridization in formaldehyde and EDC-fixed tissues
-
Pena, J. T. et al. miRNA in situ hybridization in formaldehyde and EDC-fixed tissues. Nat. Methods 6, 139-141 (2009).
-
(2009)
Nat. Methods
, vol.6
, pp. 139-141
-
-
Pena, J.T.1
-
43
-
-
45749143528
-
Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits
-
Scheppke, L. et al. Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. J. Clin. Invest. 118, 2337-2346 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 2337-2346
-
-
Scheppke, L.1
|