Flt3-ligand administration after radiation therapy prolongs survival in a murine model of metastatic lung cancer

Cancer Research

Volumn 59, Issue 24, 1999, Pages 6028-6032

  Chakravarty, Prabir K ^a   Alfieri, Alan ^a,b   Thomas, Elaine K ^a,c   Beri, Vivek ^a   Tanaka, Kathryn E ^a,c   Vikram, Bhadrasain ^a   Guha, Chandan ^a,d  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BETH ISRAEL MEDICAL CENTER   (United States)

^c AMGEN INC   (United States)

^d MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER SURVIVAL; DENDRITIC CELL; IMMUNE RESPONSE; LEWIS CARCINOMA; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; LUNG NEOPLASMS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION;

EID: 0033572416     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Porgador, A., and Gilboa, E. Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes. J. Exp. Med., 182: 255-260, 1995.
2. Lotze, M. T., Shurin, M., Davis, I., Amoscato, A., and Storkus, W. J. Dendritic cell based therapy of cancer. Adv. Exp. Med. Biol., 417: 551-569, 1997.
3. Gilboa, E., Nair, S. K., and Lyerly, H. K. Immunotherapy of cancer with dendritic cell-based vaccines. Cancer Immunol. Immunother., 46: 82-87, 1998.
4. Albert, M. L., Sauter, B., and Bhardwaj, N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature (Lond.), 392: 86-89, 1998.
5. Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., and Mulligan, R. C. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor Immunity. Proc. Natl. Acad. Sci. USA, 90: 3539-3543, 1993.
6. Soiffer, R., Lynch, T., Mihm, M., Jung, K., Rhuda, C., Schmollinger, J. C., Hodi, F. S., Liebster, L., Lam, P., Mentzer, S., Singer, S., Tanabe, K. K., Cosimi, A. B., Duda, R., Sober, A., Bhan, A., Daley, J., Neuberg, D., Parry, G., Rokovich, J., Richards, L., Drayer, J., Berns, A., Clift, S., Cohen, L. K., Mulligan, R., and Dranoff, G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA, 95: 13141-13146, 1998.
7. Maraskovsky, E., Brasel, K., Teepe, M., Roux, E. R., Lyman, S. D., Shortman, K., and McKenna, H. J. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J. Exp. Med., 184: 1953-1962, 1996.
8. Shurin, M. R., Pandharipande, P. P., Zorina, T. D., Haluszczak, C., Subbotin, V. M., Hunter, O., Brumfield, A., Storkus, W. J., Maraskovsky, E., and Lotze, M. T. FLT3 ligand induces the generation of functionally active dendritic cells in mice. Cell Immunol., 179: 174-184, 1997.
9. Lynch, D. H., Andreasen, A., Maraskovsky, E., Whitmore, J., Miller, R. E., and Schuh, J. C. Flt3 ligand induces tumor regression and antitumor immune responses in vivo. Nat. Med., 3: 625-631, 1997.
10. Chen, K., Braun, S., Lyman, S., Fan, Y., Traycoff, C. M., Wiebke, E. A., Gaddy, J., Sledge, G., Broxmeyer, H. E., and Cornetta, K. Antitumor activity and immunotherapeutic properties of Flt3-ligand in a murine breast cancer model. Cancer Res., 57: 3511-3516, 1997.
11. Peron, J. M., Esche, C., Subbotin, V. M., Maliszewski, C., Lotze, M. T., and Shurin, M. R. FLT3-ligand administration inhibits liver metastases: role of NK cells. J. Immunol., 161: 6164-6170, 1998.
12. Tamura, Y., Peng, P., Liu, K., Daou, M., and Srivastava, P. K. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science (Washington DC), 278: 117-120, 1997.
13. Eisenbach, L., Segal, S., and Feldman, M. MHC imbalance and metastatic spread in Lewis lung carcinoma clones. Int. J. Cancer, 32: 113-120, 1983.
14. Mandelboim, O., Berke, G., Fridkin, M., Feldman, M., Eisenstein, M., and Eisenbach, L. CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Nature (Lond.), 369: 67-71, 1994.
15. Chakravarty, P. K., Guha, C., Alfieri, A., Thomas, E. K., Beri, V., and B. Vikram, B. Bio-radiotherapy can induce cell-mediated immunity to control metastases in a mouse tumor model. Immunolgists, Suppl. 1: 347, 1998.
16. Brasel, K., McKenna, H. J., Charrier, K., Morrissey, P. J., Williams, D. E., and Lyman, S. D. Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice. Blood, 90: 3781-3788, 1994.
17. Banchereau, J., and Steinman, R. M. Dendritic cells and the control of immunity. Nature (Lond.), 392: 245-252, 1998.
18. Zitvogel, L., Mayordomo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., and Storkus, W. J. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell I-associated cytokines. J. Exp. Med., 183: 87-97, 1996.
19. Albert, M. L., Pearce, S. F., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., and Bhardwaj, N. Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med., 188: 1359-1368, 1998.